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Table 3 Sensitivity analysis of variables contributing to the costs of drug-related morbidity and mortality model

From: Health care use and costs of adverse drug events emerging from outpatient treatment in Germany: A modelling approach

 

Sensitivity analyses

Limit

Description of rate used*

Resulting Parameter Size

Resulting ADEs (thousands)

Resulting costs of ADEs (million €)

1.

Comparison of effect of German hospitalisation rates on model

Lower (base case)

Schneeweiss [8]: 2.4% of medical admissions

Hospitalisations**: 139,405

2,140

816

  

Upper

Dormann [7] : 3.8% of medical admissions

Hospitalisations:

3,388

1,292

    

Total: 220,724

  
    

(Death: 4,684)

  

2.

Variation in rate of physician visits according to literature***

Lower

3.5% [28]

(total = 1,731,649)

Physician visits: 635,008

2,375

828

    

Additional treatment: 1,096,640

  
  

Upper

22% [29]

(total = 11,075,753)

Physician visits: 4,061,560

11,719

1,291

    

Additional treatment: 7,014,193

  

3.

Variation in emergency department visits according to literature

Lower

0.9% [28]

432,912

2,364

914

  

Upper

3.0% [29]

1,499,696

3,431

1,380

4.

Change in only hospital admissions according to literature

Lower

0.5% [28]

Hospitalisations: 246,603

2,252

1,205

    

Deaths: 5346

  
  

Upper

4.2% [29]

Hospitalisations: 2,051,109

4,096

7,569

    

Deaths: 44,466

  
  1. *Rates refer to percentage of patients taking medications unless stated otherwise; **Equal to base case calculations; ***1/3 calculated as only physician visit and 2/3 rds with additional treatment)