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Table 3 Disease-specific subcategories studied in economic evaluations compared to burden of disease measures.

From: Burden of disease and economic evaluation of healthcare interventions: are we investigating what really matters?

Disease subcategories DALYs % of total Studies* % of total (rank) Disease subcategories YLLs % of total Studies* % of total (rank) Disease subcategories YLDs % of total Studies* % of total (rank) Disease subcategories Mortality % of total Studies* % of total (rank)
Unipolar depression 8.3 1.9 (10) Ischemic heart disease 9.2 5.7 (2) Unipolar depression 14.3 1.9 (10) Ischemic heart disease 10.3 5.7 (2)
Alzheimer's and other dementias 6.7 0.4 (28) Lung cancer 7.8 2.5 (7) Alzheimer's and other dementias 9.6 0.4 (28) Cerebrovascular disease 9.2 1.3 (14)
Ischemic heart disease 4.6 5.7 (2) Cerebrovascular disease 6.1 1.3 (14) Hearing loss, adult onset 6.8 0.2 (40) Alzheimer's and other dementias 5.9 0.4 (28)
Hearing loss, adult onset 3.9 0.2 (40) Colorectal cancer 4.0 1.3 (15) Macular degeneration 4.4 0.6 (24) Lung cancer 5.7 2.5 (7)
Cerebrovascular disease 3.7 1.3 (14) Breast cancer 2.7 2.5 (8) Osteoarthritis 4.3 1.9 (11) COPD 4.5 2.7 (5)
Lung cancer 3.4 2.5 (7) COPD 2.7 2.7 (5) Migraine 2.7 0.8 (19) Colorectal cancer 3.8 1.3 (15)
Macular degeneration 2.6 0.6 (24) Alzheimer's and other dementias 2.6 0.4 (28) Drug use disorders 2.3 0.2 (41) Lower respiratory infections 2.4 5.7 (1)
Osteoarthritis 2.5 1.9 (11) Cirrhosis 2.3 0.6 (25) Asthma 2.2 1.0 (17) Hypertensive heart disease 1.9 1.9 (12)
COPD 2.3 2.7 (5) Lymphomas, myelomas 1.5 0.4 (29) Schizophrenia 2.2 1.9 (13) Breast cancer 1.8 2.5 (8)
Colorectal cancer 2.0 1.3 (15) Liver cancer 1.5 0.2 (43) COPD 2.0 2.7 (5) Nephritis, nephrosis 1.8 1.3 (16)
Migraine 1.6 0.8 (19) Lower respiratory infections 1.5 5.7 (1) Cerebrovascular disease 1.9 1.3 (14) Prostate cancer 1.6 0.4 (31)
Breast cancer 1.4 2.5 (8) Brain cancer 1.4 0.2 (44) Rheumatoid arthritis 1.4 1.0 (18) Cirrhosis 1.3 0.6 (25)
Drug use disorders 1.4 0.2 (41) HIV- AIDS 1.3 3.1 (4) Ischemic heart disease 1.2 5.7 (2) Bladder cancer 1.3 0.2 (51)
Asthma 1.3 1.0 (17) Leukemia 1.3 0.8 (22) Panic disorder 1.2 0.2 (50) Liver cancer 1.3 0.2 (43)
Schizophrenia 1.3 1.9 (13) Bladder cancer 1.2 0.2 (51) Falls 1.0 0.2 (42) Lymphomas, myelomas 1.2 0.4 (29)
Cirrhosis 1.2 0.6 (25) Nephritis, nephrosis 1.1 1.3 (16) Parkinson disease 0.7 0.4 (30) Leukemia 0.9 0.8 (22)
Falls 0.9 0.2 (42) Prostate cancer 1.0 0.4 (31) Colorectal cancer 0.6 1.3 (15) Brain cancer 0.7 0.2 (44)
Rheumatoid arthritis 0.8 1.0 (18) Hypertensive heart disease 1.0 1.9 (12) Glaucoma 0.6 0.6 (26) Parkinson disease 0.7 0.4 (30)
HIV/AIDS 0.8 3.1 (4) Ovary cancer 0.8 0.2 (45) HIV- AIDS 0.5 3.1 (4) Kidney cancer 0.6 0.4 (32)
Panic disorder 0.7 0.2 (50) Falls 0.7 0.2 (42) Breast cancer 0.4 2.5 (8) Falls 0.5 0.2 (42)
  1. *Data from 1983-2008. Disease subcategories are presented in decreasing order of burden of disease estimates in Spain 2006. DALY: Disability adjusted life years; YLL: Years of life lost; YLD: Years lived with disability; COPD: Chronic Obstructive Pulmonary Disease; HIV- AIDS: Human Immunodeficiency Virus - Acquired Immunodeficiency Syndrome. Other disease subcategories covered by economic evaluation research (% of total studies, [% of total DALYs]): Lower respiratory infections (5.7, [0.6]), Hepatitis B and C (3.3, [0.2]), Peptic ulcer (2.7, [0.1]), Childhood vaccinable diseases (2.1, [0.04]), Epilepsy (0.8, [0.3]), Multiple sclerosis (0.8, [0.2]), Leukaemia (0.8, [0.6]), Cataracts (0.8, [0.1]), Laryngeal cancer (0.6, [0.3]), Benign prostatic hypertrophy (0.4, [0.2]), Melanoma (0.4, [0.2]), Cervical cancer (0.4, [0.2]), Appendicitis (0.4, [0.02]), Meningitis (0.4, [0.1]), Fires - unintentional injuries (0.4, [0.1]), Tuberculosis (0.4, [0.1]), Pancreatitis (0.2, [0.2]), Rheumatic heart disease (0.2, [0.2]) and Otitis media (0.2, [0.06]).