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Table 3 Summary of the Evidence

From: Credible knowledge: A pilot evaluation of a modified GRADE method using parent-implemented interventions for children with autism

Study

Quality Rating

Factors affecting qualityStrengths (+)/Weaknesses(-)

Recommendation*

Best Estimates

Aldred et al. (2005)

High

+ RCT

+ Independent randomization

+ Allocation Concealment/blinding

+ Clear outcome reporting

+ Low risk of bias

+ Valid outcome measures

Weak +

Improved symptom severity, social communication skills and parent perception of child's communication skills

Drew et al. (2002)

Moderate

+ RCT

+ Appropriate randomization

+ Clear outcome reporting

+ Low risk of bias

+Valid outcome measures

- poorly matched groups (gender)

- lack of blinding

Weak +

Improved Communication Skills

Howlin & Rutter (1987)

Low

+ Appropriately matched control group

+ Allocation Concealment/blinding

+ Clear outcome reporting

+ Low risk of bias

+ Valid outcome measures

- Quasi-Experimental design

Weak +

Improved mother/child speech and interaction

Koegel et al. (1996)

High

+ RCT

+ Appropriate randomization

+ Allocation Concealment/blinding

+ Clear outcome reporting

+ Low risk of bias

+ Valid outcome measures

Weak +

Improved parents' global style of interaction with their child

McConachie et al. (2005)

Low

+ RCT

+ Appropriately matched control group

+ Allocation Concealment/blinding

+ Clear outcome reporting

+ Low risk of bias

+ Valid outcome measures

- Quasi-Experimental design

Weak +

Improved children's vocabulary and parents' use of facilitative strategies

Neef (1997)

Very Low

+ Low risk of bias

- Quasi-Experimental design

- Inappropriately matched control group

- Allocation Concealment/blinding

- Incomplete outcome reporting

- Undetermined validity of outcome measures

Weak +

Improved parent teaching skills and child skills development

Ozonoff & Cathcart (1998)

Very Low

+ Appropriately matched control group

+ Low risk of bias

+ Valid outcome measures

- Quasi-Experimental design

- lack of blinding

- Incomplete outcome reporting

Weak +

Improved overall development, imitation, fine and gross motor skills and nonverbal conceptual skills

Rickards et al. (2000)

High

+ RCT

+ Appropriate randomization

+ Allocation Concealment/blinding

+ Clear outcome reporting

+ Low risk of bias

+ Valid outcome measures

Weak +

Improved children's IQ and behaviour problems

Schreibman et al. (1995)

Moderate

+ RCT

+ Appropriate randomization

+ Allocation Concealment/blinding

+ Low risk of bias

+ Valid outcome measures

- Incomplete outcome reporting

Weak +

Improved parental affect while interacting with their child

Tonge et al. (2001)

High

+ RCT

+ Independent randomization

+ Allocation Concealment/blinding

+ Clear outcome reporting

+ Low risk of bias

+ Valid outcome measures

Weak +

Improved self-reported parent mental health

Wang (2008)

High

+ RCT

+ Appropriate randomization

+ Allocation Concealment/blinding

+ Clear outcome reporting

+ Low risk of bias

+ Valid outcome measures

Weak +

Improved the quality of parent's interactions with their child

  1. * Recommendations are either Strong or Weak and For (+) or Against (-) the studied interventions; RCT = Randomized Controlled Trial