Table 3 Study outcomes and measures
Variable | Measure | Source |
|---|---|---|
Primary Effectiveness Outcomes | ||
   Appropriate breast cancer screening | Risk-based guideline screening performed | Genetic counselor pedigree and chart review |
   Appropriate ovarian cancer screening | Risk-based guideline screening performed | Genetic counselor pedigree and chart review |
   Appropriate colon cancer screening | Risk-based guideline screening performed | Genetic counselor pedigree and chart review |
   Appropriate hereditary thrombophilia testing | Risk-based guideline screening performed | Genetic counselor pedigree and chart review |
Secondary Effectiveness Outcomes | ||
   Patient health-related behaviors | Diet Exercise Smoking status Intention to obtain cancer screening Knowledge about genetic testing | HINTS[16] given at baseline, 3 month and 12 months |
   Provider care patterns | Orders for: Screening studies Referrals to GC Genetic testing Documentation of: Disease risk MeTree recommendations | Chart review |
   MeTree operating characteristics | Sensitivity and specificity Net Reclassification Number needed to treat to identify high risk Subgroups affected by reclassification | Pedigree review by GC Pedigree review by PCP |
   Costs | Referrals, office visits, procedures, testing | Chart review |
Implementation Outcomes | ||
   Patient experience | Satisfaction Preparedness Ease of use Level of anxiety Time to use Questions\resource needs | Post-MeTree survey MeTree Study Coordinator |
   Provider experience | Agreement with recommendations Does it change practice Recommend it to peers Quality and usefulness of reports Impact on patient flow Time spent discussing MeTree reports | Provider survey and interviews |
   Clinic needs | Resource needs to implement Assistance required for patients/providers Training/time required for clinic staff | Study coordinators Interviews |
Covariates | ||
   Demographics | Age Gender Ethnicity | MeTree input |
   Education level |  | Baseline survey |
   Insurance |  | Baseline survey |
   Family | Size % with cancer | MeTree input |
   BMI |  | Measured at triage |
   Clinic |  |  |
   Provider | Year of medical school graduation Gender | Provider survey |