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Table 5 Model comparisons for mortality and hospitalization for osteoporosis cohort, full and age-restricted

From: Comparing comorbidity measures for predicting mortality and hospitalization in three population-based cohorts

Model Full cohort (n = 28,068) Age 65+ (n = 20,090)
  c-statistic
(95% CI)
Brier
score (SD)
Δ c(%) c-statistic
(95% CI)
Brier
Score (SD)
Δ c(%)
Death
Base model 0.758
(0.745, 0.771)
0.042
(0.175)
-- 0.718
(0.703, 0.733)
0.055
(0.196)
--
+ # diagnoses 0.792
(0.780, 0.804)
0.042
(0.171)
0.034 (4.48) 0.756
(0.742, 0.769)
0.054
(0.191)
0.038 (5.29)
+ Charlson 0.811
(0.800, 0.822)
0.042
(0.170)
0.053 (6.95) 0.772
(0.759, 0.785)
0.054
(0.190)
0.054 (7.57)
+ Elixhauser 0.827
(0.817, 0.838)
0.040
(0.166)
0.069 (9.09) 0.793
(0.780, 0.805)
0.052
(0.185)
0.075 (10.42)
+ # drugs 0.782
(0.769, 0.794)
0.042
(0.172)
0.024 (3.10) 0.746
(0.732, 0.760)
0.054
(0.191)
0.028 (3.91)
+ CDS 0.778
(0.766, 0.791)
0.042
(0.172)
0.020 (2.62) 0.741
(0.727, 0.754)
0.054
(0.192)
0.023 (3.15)
One or more hospitalizations
Base model 0.579
(0.572, 0.586)
0.220
(0.157)
-- 0.550
(0.542, 0.558)
0.232
(0.129)
--
+ # diagnoses 0.667
(0.660, 0.673)
0.208
(0.178)
0.088 (15.14) 0.647
(0.639, 0.654)
0.220
(0.157)
0.097 (17.54)
+ Charlson 0.619
(0.612, 0.626)
0.216
(0.166)
0.040 (6.98) 0.598
(0.590, 0.606)
0.227
(0.141)
0.048 (8.73)
+ Elixhauser 0.637
(0.630, 0.644)
0.212
(0.173)
0.058 (10.08) 0.620
(0.612, 0.628)
0.223
(0.151)
0.070 (12.65)
+ # drugs 0.631
(0.624, 0.638)
0.213
(0.168)
0.052 (9.02) 0.609
(0.601, 0.618)
0.225
(0.144)
0.059 (10.80)
+ CDS 0.618
(0.611, 0.625)
0.215
(0.166)
0.039 (6.69) 0.597
(0.589, 0.605)
0.227
(0.141)
0.047 (8.61)
Two or more hospitalizations
Base model 0.606
(0.597, 0.615)
0.124
(0.243)
-- 0.570
(0.559, 0.580)
0.139
(0.245)
--
+ # diagnoses 0.697
(0.688, 0.705)
0.118
(0.235)
0.090 (14.92) 0.669
(0.659, 0.679)
0.133
(0.238)
0.099 (17.37)
+ Charlson 0.650
(0.641, 0.659)
0.122
(0.240)
0.044 (7.19) 0.619
(0.609, 0.630)
0.137
(0.242)
0.050 (8.73)
+ Elixhauser 0.672
(0.663, 0.681)
0.119
(0.237)
0.066 (10.86) 0.645
(0.634, 0.655)
0.135
(0.239)
0.075 (13.15)
+ # drugs 0.656
(0.647, 0.665)
0.121
(0.237)
0.050 (8.28) 0.625
(0.615, 0.636)
0.136
(0.240)
0.056 (9.80)
+ CDS 0.651
(0.642, 0.660)
0.121
(0.238)
0.045 (7.41) 0.620
(0.610, 0.631)
0.137
(0.240)
0.051 (8.89)
  1. Base model includes age, age2, sex, income quintile, and geography
  2. CDS = Chronic Disease Score
  3. Δc = difference in the c-statistic between the base and full models; c-statistics in boldface font are significantly different from the c-statistic for the base model, according to the method of DeLong et al. [39]
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