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Table 5 Model comparisons for mortality and hospitalization for osteoporosis cohort, full and age-restricted

From: Comparing comorbidity measures for predicting mortality and hospitalization in three population-based cohorts

Model

Full cohort (n = 28,068)

Age 65+ (n = 20,090)

 

c-statistic

(95% CI)

Brier

score (SD)

Δ c(%)

c-statistic

(95% CI)

Brier

Score (SD)

Δ c(%)

Death

Base model

0.758

(0.745, 0.771)

0.042

(0.175)

--

0.718

(0.703, 0.733)

0.055

(0.196)

--

+ # diagnoses

0.792

(0.780, 0.804)

0.042

(0.171)

0.034 (4.48)

0.756

(0.742, 0.769)

0.054

(0.191)

0.038 (5.29)

+ Charlson

0.811

(0.800, 0.822)

0.042

(0.170)

0.053 (6.95)

0.772

(0.759, 0.785)

0.054

(0.190)

0.054 (7.57)

+ Elixhauser

0.827

(0.817, 0.838)

0.040

(0.166)

0.069 (9.09)

0.793

(0.780, 0.805)

0.052

(0.185)

0.075 (10.42)

+ # drugs

0.782

(0.769, 0.794)

0.042

(0.172)

0.024 (3.10)

0.746

(0.732, 0.760)

0.054

(0.191)

0.028 (3.91)

+ CDS

0.778

(0.766, 0.791)

0.042

(0.172)

0.020 (2.62)

0.741

(0.727, 0.754)

0.054

(0.192)

0.023 (3.15)

One or more hospitalizations

Base model

0.579

(0.572, 0.586)

0.220

(0.157)

--

0.550

(0.542, 0.558)

0.232

(0.129)

--

+ # diagnoses

0.667

(0.660, 0.673)

0.208

(0.178)

0.088 (15.14)

0.647

(0.639, 0.654)

0.220

(0.157)

0.097 (17.54)

+ Charlson

0.619

(0.612, 0.626)

0.216

(0.166)

0.040 (6.98)

0.598

(0.590, 0.606)

0.227

(0.141)

0.048 (8.73)

+ Elixhauser

0.637

(0.630, 0.644)

0.212

(0.173)

0.058 (10.08)

0.620

(0.612, 0.628)

0.223

(0.151)

0.070 (12.65)

+ # drugs

0.631

(0.624, 0.638)

0.213

(0.168)

0.052 (9.02)

0.609

(0.601, 0.618)

0.225

(0.144)

0.059 (10.80)

+ CDS

0.618

(0.611, 0.625)

0.215

(0.166)

0.039 (6.69)

0.597

(0.589, 0.605)

0.227

(0.141)

0.047 (8.61)

Two or more hospitalizations

Base model

0.606

(0.597, 0.615)

0.124

(0.243)

--

0.570

(0.559, 0.580)

0.139

(0.245)

--

+ # diagnoses

0.697

(0.688, 0.705)

0.118

(0.235)

0.090 (14.92)

0.669

(0.659, 0.679)

0.133

(0.238)

0.099 (17.37)

+ Charlson

0.650

(0.641, 0.659)

0.122

(0.240)

0.044 (7.19)

0.619

(0.609, 0.630)

0.137

(0.242)

0.050 (8.73)

+ Elixhauser

0.672

(0.663, 0.681)

0.119

(0.237)

0.066 (10.86)

0.645

(0.634, 0.655)

0.135

(0.239)

0.075 (13.15)

+ # drugs

0.656

(0.647, 0.665)

0.121

(0.237)

0.050 (8.28)

0.625

(0.615, 0.636)

0.136

(0.240)

0.056 (9.80)

+ CDS

0.651

(0.642, 0.660)

0.121

(0.238)

0.045 (7.41)

0.620

(0.610, 0.631)

0.137

(0.240)

0.051 (8.89)

  1. Base model includes age, age2, sex, income quintile, and geography
  2. CDS = Chronic Disease Score
  3. Δc = difference in the c-statistic between the base and full models; c-statistics in boldface font are significantly different from the c-statistic for the base model, according to the method of DeLong et al. [39]