Variable | Mean | Distribution | 95th percentile * | Reference(s) |
---|---|---|---|---|
H. pylori prevalence | 0.23 | Uniform | 0.05 - 0.4 | |
Initial ulcer status | 0.10 | Beta | 0.025-.022 | |
Cost of IgA serology | $29 | Gamma | 12.53-51.34 | ** |
Cost of IgG serology | $29 | Gamma | 12.53-51.34 | ** |
Cost of stool Ag detection | $21 | Gamma | 6.20-44.56 | ** |
Cost of urease breath test | $133 | Gamma | 28.81-316.05 | ** |
Cost of endoscopy w/biopsy and pathologist time | $511 | Gamma | 156.21-2552.46 | *** |
Cost of eradication therapy | $355 | Gamma | 186.55-576.02 | *** |
Cost of 2-week PPI therapy | $40 | Gamma | 10.92-87.51 | *** |
Breath test sensitivity | 0.95 | Triangular | 0.90 - 0.98 | |
Breath test specificity | 0.96 | Triangular | 0.94 - 0.99 | |
IgA serology sensitivity | 0.85 | Triangular | 0.79 - 0.90 | |
IgA serology specificity | 0.79 | Triangular | 0.65 - 0.85 | |
IgG serology sensitivity | 0.85 | Triangular | 0.79 - 0.90 | |
IgG serology specificity | 0.79 | Triangular | 0.65 - 0.85 | |
Stool Ag sensitivity | 0.93 | Triangular | 0.90 - 0.99 | |
Stool Ag specificity | 0.92 | Triangular | 0.90 - 0.99 | |
Probability of relief of symptoms after two weeks of triple therapy (NUD§) | 0.53 | Beta | 0.28-0.66 | [57] |
Probability of relief of symptoms after two weeks of triple therapy (PUD§§) | 0.49 | Beta | 0.28-0.70 | [11] |
Probability of relief of symptoms after two-week PPI trial (NUD) | 0.40 | Beta | 0.40-0.78 | Expert opinion§§§ |
Probability of relief of symptoms after two-week PPI trial (PUD) | 0.32 | Beta | 0.47-0.85 | [11] |
Probability of relapse at one year after eradication therapy (NUD) | 0.32 | N/A | N/A | [57] |
Probability of relapse at one year after eradication therapy (PUD) | 0.37 | N/A | N/A | [11] |