Recruitment of B Positive participants
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Target population age ≥ 35, HBsAg + ve for ≥ 6 months, born in China, Hong Kong, Vietnam
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Contact testing and immunisation
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Not factored into the model
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Seroprevalence data in target populations
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Data provided by Nguyen et al [19]
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• 10.7% for people born in China
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• 10.5% for people born in Vietnam
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• 7.7% for people born in Hong Kong
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Initial testing to confirm CHB
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Not factored in GP consultation calculations
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Program participation rates
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Base case assumption is 25% of eligible people enrolled
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Follow up requirements
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• Routine surveillance arm: 2 GP appointments/year
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• Enhanced HCC surveillance arm: 2 GP appointments/year
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• Interferon treatment: 6 specialist appointments/year
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• Entecavir treatment (includes those with liver failure): 4 specialist appointments/year
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• Patients with HCC: assumed monthly follow up
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Viral load distribution by age
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Based upon REVEAL study, [22] as participant profile largely matches that of B Positive participants
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ALT cut-off levels
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ALT≥ 1.5 × ULN triggers further evaluation in the absence of clinical data; ULN differentiated by participant age
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Progression rates through disease stages
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Constant over time
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Patients with high VL and abnormal liver function
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30% receive first line interferon for 12 months
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• 30% seroconvert and receive no further treatment
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• 70% commence entecavir the following year
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70% receive entecavir as first-line treatment
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• 20% seroconvert in the first year of entecavir treatment and receive no further treatment
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• 80% continue lifelong entecavir
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Patients with liver failure
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All receive entecavir
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