Table 2 Associations of PNPLA3 rs738409 with health utilization and hospitalization (n = 3759)
Reference: PNPLA3 rs738409 CC | Effect on annual outpatient visits, % Bootstrap (95 %-CI)a | Hospitalization, OR Bootstrap (95 %-CI) | Effect on annual inpatient days, % Bootstrap (95 %-CI)a |
|---|---|---|---|
Model 1 (age, sex, school education, income, alcohol intake, smoking status, GFR) | |||
CG | −3.17 (−9.00, +4.08) | 1.01 (0.83, 1.21) | −9.00 (−25.12, +7.10) |
GG | +2.93 (−12.9, +21.7) | 1.51 (1.02, 2.15)* | +7.38 (−22.45, +42.87) |
Model 2: model 1 + Functional Comorbidity Index | |||
CG | −2.43 (−8.5, +3.5) | 1.03 (0.89, 1.23) | −10.31 (−23.1, +10.44) |
GG | +1.81 (−11.62, +18.29) | 1.51 (1.01, 2.28)* | +7.49 (−21.24, +48.61) |
Model 3: Model 2 + hepatic steatosis | |||
CG | −2.64 (−8.89, +2.65) | 1.03 (0.83, 1.23) | −11.30 (−26.33, +8.15) |
GG | +1.98 (−9.49, +19.92) | 1.54 (1.03, 2.17)* | +7.51 (−23.45, +59.25) |
Model 4: Model 2 + ALT | |||
CG | −2.33 (−8.82, +4.83) | 1.04 (0.85, 1.26) | −9.90 (−23.65, +3.81) |
GG | +2.84 (−9.20, +21.91) | 1.56 (1.02, 2.27)* | +8.80 (−22.86, 50.62) |
Model 5: Model 2 + ferritin | |||
CG | −2.41 (−7.74, +5.52) | 1.02 (0.85, 1.20) | −11.3 (−25.02, +7.89) |
GG | +1.57 (−12.67, +25.28) | 1.49 (1.01, 2.35)* | +7.42 (−67.07, +49.20) |
Model 6: Model 1 + metabolic syndrome | |||
CG | −2.45 (−8.97, +4.41) | 1.03 (0.84, 1.31) | −9.73 (−24.1, +10.60) |
GG | +4.13 (−9.85, +24.94) | 1.53 (1.02, 2.28)* | +6.23 (−24.49, +40.60) |
Model 7: Model 1 + waist circumference | |||
CG | −2.48 (−9.04, +4.56) | 1.02 (0.84, 1.23) | −9.34 (−25.14, +7.67) |
GG | +4.18 (−9.17, +20.31) | 1.51 (1.02, 2.26)* | +7.29 (−22.41, +50.45) |
Model 8: Model 1 + BMI | |||
CG | −2.74 (−8.65, +4.67) | 1.02 (0.85, 1.22) | −9.44 (−23.11, +8.88) |
GG | +3.31 (−14.11, +20.54) | 1.51 (0.99, 2.23)* | +6.75 (−28.51, +43.60) |
Model 9: Model 1 + triglycerides | |||
PNPLA3 | |||
CG | −2.70 (−8.43, +5.48) | 1.02 (0.87, 1.31) | −7.83 (−23.36, +10.71) |
GG | +3.16 (−11.65, +23.22) | 1.51 (1.01, 2.21)* | +7.02 (+22.9, +58.96) |
Model 10: Model 1 + HDL cholesterol | |||
CG | −2.83 (−9.55, +3.89) | 1.005 (0.83, 1.25) | −9.52 (−23.12, +7.25) |
GG | +3.24 (−7.22, +23.89) | 1.52 (1.02, 2.22)* | +7.97 (−27.34, +44.13) |
Model 11: Model 1 + systolic blood pressure | |||
CG | −2.69 (−8.49, +3.44) | 1.02 (0.85, 1.24) | −9.03 (+26.12, +10.44) |
GG | +3.44 (−14.57, +19.68) | 1.52 (1.03, 2.32)* | +7.02 (−22.73, +43.84) |
Model 12: Model 1 + serum glucose | |||
CG | −2.92 (−9.10, +4.59) | 1.02 (0.83, 1.22) | −9.59 (−24.54, +12.97) |
GG | +3.30 (+11.4, +23.1) | 1.49 (1.02, 2.24)* | +6.06 (−24.05, 43.55) |
Model 13: Model 1 + hbA1c | |||
CG | −3.32 (−9.67, +4.24) | 1.02 (0.83, 1.22) | −9.20 (−23.78, +7.61) |
GG | +4.44 (−11.01, +26.81) | 1.52 (0.96, 2.05)* | +7.79 (−21.70, +41.90) |