From: Fall-related injuries in a nursing home setting: is polypharmacy a risk factor?
Characteristics of fallers | Injured | Not injured | |||
---|---|---|---|---|---|
141 (48.1%) | 152 (51.9%) | p* | O.R. | 95% C.I. | |
No. of medications | 0.50 | ||||
0 | 1 (0.7%) | 0 (0%) | ref | -- | |
1-3 | 26 (18.4%) | 32 (21.1%) | 0.86 | 0.48-1.56 | |
4 or more | 114 (80.9%) | 120 (78.9%) | 0.96 | 0.25-3.71 | |
No. of psychotropic medications | 0.88 | ||||
0 | 28 (19.9%) | 27 (17.8%) | ref | -- | |
1-3 | 108 (76.6%) | 120 (78.9%) | 0.92 | 0.41-2.06 | |
4 or more | 5 (3.5%) | 5 (3.3%) | 1.27 | 0.23-7.03 | |
Typical antipsychotics | 34 (24.1%) | 42 (27.6%) | 0.49 | 0.83 | 0.49-1.40 |
Atypical antipsychotics | 9 (6.4%) | 19 (12.5%) | 0.07 | 0.47 | 0.20-1.09 |
Antidepressants | 4 (2.8%) | 2 (1.3%) | 0.34 | 2.19 | 0.39-12.14 |
New generation antidepressants | 31 (22.0%) | 35 (23.0%) | 0.83 | 0.94 | 0.54-1.63 |
Benzodiazepines | 78 (56.0%) | 90 (58.6%) | 0.66 | 0.90 | 0.56-1.43 |
Hypnotics & sedatives | 3 (2.1%) | 3 (2.0%) | 0.92 | 1.08 | 0.21-5.43 |
Antiepileptics | 36 (25.5%) | 37 (24.3%) | 0.81 | 1.06 | 0.62-1.81 |
Antihistamines | 5 (3.5%) | 9 (5.9%) | 0.34 | 0.58 | 0.19-1.78 |
Antihypertensives & diuretics | 104 (74.5%) | 106 (69.1%) | 0.30 | 1.30 | 0.78-2.17 |
Antiarrhythmics | 16 (11.3%) | 13 (8.6%) | 0.42 | 1.36 | 0.63-2.95 |
Hypoglycaemics & insulin | 26 (19.1%) | 27 (17.1%) | 0.65 | 1.14 | 0.63-2.08 |
Antiparkinson drugs | 24 (17.0%) | 21 (13.8%) | 0.44 | 1.28 | 0.67-2.41 |
Vitamins | 61 (43.3%) | 71 (46.7%) | 0.55 | 0.87 | 0.54-1.37 |
Opioid analgesics | 10 (7.1%) | 9 (5.9%) | 0.68 | 1.21 | 0.47-3.07 |
Antithrombotic agents | 58 (41.8%) | 71 (46.1%) | 0.46 | 0.84 | 0.53-1.33 |
NSAIDs | 31 (22.0%) | 30 (19.7%) | 0.63 | 1.14 | 0.65-2.01 |
Cardiac glycosides & nitrates | 43 (30.5%) | 47 (30.9%) | 0.93 | 0.98 | 0.59-1.61 |
Gastrointestinal agents | 78 (56.0%) | 86 (55.9%) | 0.93 | 1.01 | 0.63-1.59 |