Using U.S. Medicare records to evaluate the indirect health effects on spouses: a case study in Alzheimer’s disease patients
© Gilden et al.; licensee BioMed Central Ltd. 2014
Received: 22 September 2013
Accepted: 27 June 2014
Published: 7 July 2014
The burden experienced by spouses of patients with Alzheimer’s disease (AD) may have negative consequences for their physical health. We describe here a method for analyzing United States Medicare records to determine the changes in health service use and costs experienced by spouses after their marital partner receives an AD diagnosis.
We initially identified all beneficiaries in the 2001–2005 Medicare 5% sample who had multiple claims listing the ICD-9 diagnostic code for AD, 331.0. The 5% sample includes spouses who share a Medicare account with their marital partners because they lack a sufficient work history for full eligibility on their own. A matched cohort study assessed incremental health costs in the spouses of AD patients versus a control group of spouses of non-AD patients. Longitudinal and cross-sectional analyses tracked the impact of a patient’s AD diagnosis on his or her spouse’s healthcare costs.
Our method located 54,593 AD patients of whom 11.5% had spouses identifiable via a shared Medicare account. AD diagnosis in one member of a couple was associated with significantly higher monthly Medicare payments for the other member’s healthcare. The spouses’ elevated costs commenced 2 to 3 months before their partners’ AD diagnosis and persisted over the follow-up period. After 31 months, the cumulative additional Medicare reimbursements totaled a mean $4,600 in the spouses of AD patients. This excess was significant even after accounting for differences in baseline health status between the cohorts.
The study methodology provides a framework for comprehensively evaluating medical costs of both chronically ill patients and their spouses. This method also provides monthly data, which makes possible a longitudinal evaluation of the cost effects of specific health events. The observed correlations provide a coherent demonstration of the interdependence between AD patients’ and spouses’ health. Future research should examine caregiving burden and other possible factors contributing to the AD spouses’ health outcomes. It should also extend the method presented here to evaluations of other chronic diseases of the elderly.
KeywordsAlzheimer’s disease Dementia Medicare Administrative records Spouses Medical costs Indirect costs Caregivers Psychological stress
Cost-of-disease studies in dementia frequently group together the various dementia types because of difficulty in distinguishing between different diagnoses in the absence of detailed clinical assessments. Nonetheless, it is important to understand the full costs of Alzheimer’s disease (AD) since it is the most common dementia and its prevalence is increasing rapidly . AD furthermore has its own particular disease profile [2, 3]. It is associated with specific care interventions (direct costs) [4, 5] and makes particular demands on caregivers (indirect costs) [6, 7]. The study of AD’s secondary effects has proved especially problematic: Past attempts to calculate incremental health costs among informal dementia or AD caregivers have varied widely because study inclusion criteria, control groups and sources of cost data are not consistently constructed [8, 9].
Spouses of AD patients experience both a large caregiving burden and special psychosocial issues [10, 11]. A study of caregiving wives of patients with either AD or vascular dementia reported that their caregiving time averaged 8 hours per day after 3 years . In addition, spouses’ intimate daily connection to their AD partners triggers a growing sense of grief as their partners’ ability to interact declines [13, 14]. Social isolation and financial difficulties also commonly ensue [15, 16].
The best approach to quantifying these stressors’ impacts on caregivers and particularly spousal caregivers remains unresolved. A large number of studies report that the stress experienced by caregivers results in health declines, which especially affect elderly caregivers of dementia patients [17–19]. However, few studies consider the spousal role in its entirety, and those that do still confound AD with dementia in general [20, 21]. These studies also were subject to limitations in matching the spousal and control populations that may have masked healthcare cost differences. A recent study of healthcare costs matched household members of AD patients with a control population but did not separately identify spouses .
To help address gaps in health economic knowledge on the spousal experience, we propose a Medicare claims-based method for looking at AD patients, their spouses and the joint impact the two have on direct medical spending for elderly adults by the United States’ Medicare fee-for-service program. Medicare claims present the possibility of identifying a large number of spouses of AD patients and finding a closely matched control group since detailed diagnosis, service utilization and cost data are available for each group. Because of the large number of detailed claims records accumulated over many years, it is possible to conduct a longitudinal investigation to assess the impact of AD diagnosis on spouses’ health. As described here, this claims-based approach provides a model for studying the effect of other chronic conditions on spousal healthcare service utilization and costs.
Identifying persons with Alzheimer’s disease
Advancing age is a strong predictor of AD onset, with the prevalence of diagnosed AD increasing exponentially after the age of 65, from approximately 3% of persons aged 65–74 to just over 30% of persons aged 85+ . U.S. Medicare claims records therefore are an appropriately representative source for estimating the impact of AD patients and their spouses on the US healthcare system.
The U.S. Centers for Medicare and Medicaid Services (CMS) makes available the claims records for a random 5% sample of Medicare beneficiaries for research purposes . This 5% sample encompasses approximately 2 million people representative of the entire US elderly and permanently disabled population. Not counting deaths, 99.5% of the population is carried over during CMS’s annual updates.
We identified our AD population by evaluating all beneficiaries in the 2001–2005 Medicare 5% sample who had claims listing a primary diagnosis of AD (ICD-9 diagnosis code 331.0). Two corroborating AD diagnoses appearing as the primary diagnosis in outpatient claims or one corroborating AD diagnosis listed in a hospitalization claim were required to ensure the robustness of diagnosis. These corroborating healthcare encounters had to occur in the two years following the month of the initial diagnosis (which defined the index date). Other dementia-related codes were not taken into consideration so as to achieve greater diagnostic specificity for AD within the cohort.
Detailed Medicare claims records are available only for the months in which beneficiaries are enrolled in the traditional Medicare fee-for-service (FFS) coverage . This study therefore excluded AD patients and their spouses if they had Medicare managed care coverage during their index month or for ≥6 months in the pre-index year.
Once we had constructed a corroborated AD population, we proceeded to assign spousal relationships. We used a method similar to the one described by Iwashyna et al. [26, 27]. It takes advantage of a special feature of the Medicare beneficiary numbering system to accurately identify married couples.
CMS assigns each new Medicare beneficiary an 11-digit identification code known as the Medicare Health Insurance Claim Number, or HICN. The first nine digits are the Claim Account Number (CAN), which is the same as the Social Security Number if the beneficiary is entitled to Medicare based on his or her own work history. Persons without sufficient work history for full eligibility (usually ten years) may receive Medicare benefits through their spouses. These individuals are assigned the same CAN as their spouse, but the last one or two characters of their HICN are different. These characters represent the Beneficiary Identification Code (BIC). Special BICs identify spouses who share an account established through their partner’s work history. CMS selects the Medicare 5% sample based on the CAN, effectively guaranteeing that primary beneficiaries and dependent spouses are selected together.
Using this approach excludes couples in which both members are eligible for Medicare due to their separate work histories. In those situations, each member has a different CAN, and chance co-selection in the 5% Medicare sample would be undetectable without further information.
Cross-sectional and longitudinal matched control cohorts
After identification of the AD spouse study population, the Medicare records further allowed us to match the AD spouses to a control cohort married to partners without AD. Our selection and matching approach yielded four groups created sequentially: AD patients, AD spouses, matched control spouses and non-AD spouses of matched controls. The comparisons of interest described here are between the AD spouses and control spouses only.
The marriage identification and inclusion criteria were the same for the controls as for the AD spouses except that the controls’ marital partners could not have any record of an AD diagnosis. Each control and AD spouse was then matched according to race/ethnicity, age category and urban/rural residency status. Matching by comorbidity was not done because it would interfere with the study’s examination of the correlation between AD spousal status, certain related diagnoses and their impact on overall costs. The controls received the same index date as their matching AD spouses (i.e., the AD patient’s initial diagnostic date).
We compared the AD spouse and control cohorts cross-sectionally and longitudinally. For the cross-sectional analyses, we constructed in each study year (2001, 2002, 2003, 2004 and 2005) a matched comparison cohort for all identified AD spouses. To be included in the annual spousal profiles, members of the AD and comparison couples had to have at least six months of Medicare FFS records within the given year.
In order to support a longitudinal analysis, matching controls also were selected for the spouses of newly diagnosed AD patients first identified in each study year. AD patients were required to have at least the 12 previous months of Medicare FFS claims devoid of AD diagnoses to qualify for each year’s incident AD population, a criterion that did not apply to the other study defined populations. For the AD spouse-control matched pairs, the observation period commenced six months before the index date and continued until both members of the pair had died or lost FFS eligibility.
It was not possible to observe a prior diagnostic “clean period” for any of the AD patients identified in the first study year, i.e. 2001. These patients were assigned to the cross-sectional analysis only.
JEN frailty index
We found it necessary to include a covariate indicating each person’s pre-index well-being when constructing regression models of the AD spouse and control cohorts’ healthcare costs. Finding an appropriate marker for patients’ overall health and physical status poses difficulties because of Medicare claims records’ lack of clinical data. In addition, the scope of potential comorbidities in this elderly study population is not adequately represented in a standard comorbidity index such as Charlson or its adaptations [28, 29] that cover only a limited number of hospital diagnoses. Another option, stratifying by specific comorbidities, would have been quite challenging statistically. We chose instead to employ the broad-ranging JEN frailty index (JFI). The JFI takes into account claims filed by all providers, not just hospitals. It is therefore particularly useful in patients with complicated clinical profiles. Furthermore, this index was developed for specific use in Medicare/Medicaid database analyses as part of the Medicare/Medicaid Integration Project, funded by the Robert Wood Johnson Foundation . We have found it to be significantly correlated with Medicare and Medicaid expenditures as well as mortality [31, 32].
The almost 1,800 diagnoses included in the JFI are classified into 13 condition categories. The 13 condition categories are designed to provide an indication of individual patient impairment. They include minor ambulatory limitations, severe ambulatory limitations, cognitive developmental disability, chronic mental illness, dementia, sensory disorders, self-care impairment, syncope, cancer, chronic medical disease, pneumonia, renal disorders and systemic disorders (e.g. septicemia). A patient’s personal index is derived by counting the presence of these condition categories in the previous year’s diagnostic claims.
The focus of this report is to describe the utility of Medicare claims records for identifying spouses and studying the secondary health effects they experience when their partners have chronic disabling illness, AD in particular. To indicate the effectiveness of this approach, we discuss here the descriptive healthcare utilization and cost comparisons that we obtained. We also mention the primary result of a multiple regression analysis of healthcare costs and utilization. This analysis, constructed in stepwise fashion, included as covariates socioeconomic status, national region of residence, index year, select pre-index (but not post-index) chronic conditions, annual JFI level and status as AD spouse or control. These more extensive multivariate cost and illness analyses are the subject of a conference presentation  and a manuscript in preparation.
The study was conducted in accordance with a data use agreement from the U.S. Centers for Medicare and Medicaid Services. The study received a waiver of review from the New England Institutional Review Board on the basis that the study’s necessary use of protected health information (PHI) presented no more than minimal risk to individuals’ privacy.
Characteristics of the study population
Annual profiles of corroborated AD patients, 2001-2005
Population annual characteristics
Observed AD prevalence1
Age in year (<1% in below 55 ages)
Nursing home at index2
Nursing home entry during follow-up2
Death during follow-up
Mean follow-up months
Percent of total AD patients
Incident AD diagnoses 3
Percent of total AD patients
Identified incident AD spouses
Percent of total AD patients
Spousal identification rates for the corroborated Alzheimer’s disease population and spousal identification rates, 2001-2005
Total corroborated AD patients1
Number of study-identified spouses1
Expected number of spouses2
Study’s rate of spousal identification
Study total estimate
The initial 2001 cohort (n = 23,038) also was substantially lower than in the other years (Table 1) because we had no ability to look retrospectively at the records and identify patients receiving care related to an AD diagnosis before but not during 2001. It is likely that many of these AD-diagnosed Medicare beneficiaries reappeared in the 2002 AD cohort. From 2002 on, such patients received enough repeated care to meet our corroborated AD criteria. The lack of follow-up time past 2005 limited our ability to corroborate AD patients after their initial diagnosis. This restriction reduced the incident AD population observed in 2005.
Pooled annual cohorts: baseline demographics, 2001-2005 1
AD spouses (N = 6,291)
Matched controls (N = 16,322)2
AD spouses’ health care costs
AD spouses vs. matched controls: Medicare expenditures, 2001-2005 1
Pooled annual cohorts (N = 6,291)
Median Medicare FFS months/year
Mean Medicare FFS months/yr. (95% CI)
11.83 (11.82, 11.84)
11.85 (11.83, 11.86)
Median total expenditures/year
Mean total expenditures/yr. (95% CI)
$8,206 ($7,967, $8,445)
$6,640 ($6,414, $6,866)
Mean total PMPM
Incident cohorts (N = 2,987)
Multiple regression analysis 2
Impact on Medicare expenditures (95% CI), AD spouse vs. control
29% (18%, 42%)
The methodology described in this report presents a novel approach to better quantifying the burden on the healthcare system represented by the spouses of patients with AD or other debilitating chronic conditions. By linking spouses with shared CANs in the Medicare 5% sample and creating a control spouse cohort, the impact of an AD diagnosis on the spousal dyad was explored cross-sectionally and longitudinally. The temporal association between the patients’ AD diagnosis and the increase in Medicare expenditures for their spouses as compared to controls illustrates the strength of our method. That relationship underscores the impact of the AD diagnosis on spouses’ health, independent of a couple’s joint lifestyle or other common factors that might contribute to the AD spouses’ medical costs. The ability to track the details of cost and service utilization on a monthly basis is yet another advantage to utilizing Medicare records rather than relying on self-reports of healthcare utilization. Despite such benefits, several complex issues concerning the validity of our approach deserve further examination.
AD ascertainment through Medicare claims
Medicare claims records are robust since they list all types of services, including those performed on both an inpatient and outpatient basis. Moreover, the need to receive payment for their services disciplines providers to be complete when filing these claims.
Concern nonetheless remains about the reliability of using Medicare claims to summarize the impact of AD and other dementias on resource utilization. Even when an AD-related diagnosis is appropriate, providers faced considerable hurdles obtaining Medicare payment during our study period [35–37]. The literature suggests a physician and hospital bias toward filing claims based on more clear-cut and easily reimbursable diagnostic codes related to patients’ physical comorbidities rather than on patients’ cognitive impairments [35, 37].
Two studies have examined Medicare data contemporaneous with our study period [38, 39]. One study included patients with presenile/senile dementia diagnostic codes in their claims as well as those with 331.0 for AD . It used only survey responses to validate these diagnoses. The other study  carried out formal clinical assessments to determine who had AD, other forms of dementia or mild cognitive impairment in the Aging Demographics and Memory Study (ADAMS) cohort of 856 older Americans.
After reviewing the cohort’s Medicare claims, the ADAMS investigators concluded that the sensitivity and specificity of those claims for capturing an AD diagnosis was respectively, 64% and 95%. By comparison, Medicare claims sensitivity and specificity for all-cause dementia was 85% and 89%. Identifying AD patients through Medicare claims is thus a very selective strategy but misses a substantial percentage of patients, probably those with atypical or mild cases.
The present study’s AD population represents a core of easily identified cases receiving recurring AD-related care. Broadening our AD definition could have increased the study population by as much as two-fold [40, 41], but including less severe and more ambiguous cases of AD would have weakened our ability to investigate AD-specific spillover effects on spousal health. Comparing the relationship between various coding patterns and clinical signs of cognitive impairment would help in the development of more accurate algorithms for parsing Medicare claims. That examination is outside our current scope.
Characteristics of the identified spouses
Since the goal of this study was to evaluate the secondary effects of AD on spouses, our ability to identify only a quarter of the potential spouses becomes important. In making this identification, we took advantage of a wrinkle in the Medicare beneficiary numbering system that identifies spouses without their own retirement accounts through their partners’ Social Security numbers. Medicare automatically includes both such spouses when constructing its 5% beneficiary sample.
Our method identified many primary Medicare beneficiaries who were the spouses (primarily husbands) of dependent partners diagnosed with AD. It omitted households in which both spouses had large enough prior earnings to qualify for Medicare on their own. Women with substantial work histories make up a growing proportion of Medicare beneficiaries, however, and study of spousal effects in two wage-earner couples is becoming more important.
It is possible that spouses with substantial work experience react more resiliently to their partner’s AD. They may have greater financial resources and feel more self-empowered than a spouse with little outside work experience. Conversely, a spouse who has spent a majority of time at home may be more familiar with and/or less burdened by home-based caregiving. Our study could not be sensitive to these possibilities.
An additional 25% of elderly Medicare spouses could be captured when they apply for widow benefits and emerge as married beneficiaries in the Medicare denominator (demographic) data files . Employing this method for spousal healthcare cost and utilization studies would require claim records for the entire Medicare elderly population during the study years plus demographic data for many years beyond. These files were not available to us.
A still more complete spousal identification would involve linking AD case information with address records for each year and matching cohabitants via their common addresses. This method would create a complete file that includes all cohabiting partners, whether they are married or not, while excluding married couples who are separated (a small proportion of elderly spouses ). We could then describe in depth the differences between spouses according to their previous work history.
Distributing Medicare address files raises privacy concerns, however, and CMS usually does not release this information. Even if the agency did allow access, the address records would present a significant processing challenge because they lack a standard format. Another challenge would be excluding elderly cohabitants who are simply relatives or roommates rather than spouses.
Spouses first or caregivers?
Identifying the entire spousal population solely through Medicare claims would still yield no practical way to determine the extent of their caregiving role. A considerable literature on AD and other disabilities does document that cohabiting spouses are usually the chief caregiving resource when they are not incapacitated themselves [12, 42–45]. National U.S. surveys have found that up to 80% of spouses living with elderly disabled partners devote substantial time to caregiving tasks [44, 45].
This overall spousal caregiving burden does not provide the basis for individual risk analysis, however, and even knowing the caregiving obligations of each spouse would be insufficient to predict their health risk. The nature of a couple’s relationship influences whether caregiving is experienced as fulfilling or a strain, and that subjective interpretation in turn can affect health and mortality [46–48]. The nature of the spousal relationship also independently affects spouses’ mortality when their partners become seriously ill or die [11, 49]. These observations are conspicuously true of cognitive impairment: Dementia in one spouse greatly increases the risk of dementia in the other, and spousal closeness decreases dementia progression in the affected partner [50, 51].
Spouses’ interrelated health outcomes may be influenced by a couple’s shared environment as well as to their emotional ties. It will not be possible to capture the individual, granular details of this phenomenon through claims records alone. Our method nonetheless allows researchers to show the population-level patterns that mirror the underlying individual interactions.
The question also arises as to whether spouses of patients with other chronic diseases would experience similar increases in healthcare costs. There are rare examples of this phenomenon existing for other disease states  or in association with widowhood from decedents of other chronic conditions . The goal of our study was to find a connection between spouses’ healthcare status and their partners’ AD diagnosis while statistically controlling for a broad spectrum of impairments with the JFI. This temporal association is illustrated in Figure 1. One can speculate that AD’s particular behavioral and cognitive effects are especially stressful for spouses, both emotionally and in terms of caregiving burden. It will be a fruitful line of research to compare the spousal results presented in Table 4 and Figure 1 with results obtained for other chronic diseases. The methods we establish here can form the basis for such research.
Comprehensiveness of costs
Medicare FFS data includes claims related to outpatient and inpatient services, short-term skilled nursing home stays, hospice, select home health services, physician/medical professional services, and durable medical equipment. It does not include certain behavioral health services, many home-care services, or long-term nursing home residencies. Other omissions are payments by private supplementary insurance, Medicaid or pre-2006 outpatient pharmacy costs. So long as the study focuses on comparing relative costs in carefully defined exposed and unexposed cohorts, restricting the quantitative results to Medicare FFS expenditures will not make a qualitative difference in its conclusions. Analyses of data linked from the different sources described above would further advance the research reported here.
Examining the claims records of married Medicare beneficiaries is a valid, effective approach for studying the interrelationship between spousal healthcare costs and a partner’s AD diagnosis. We conclude that the Medicare claims records provide detailed findings specific for a core group of patients with long-term AD and that these records have the extra advantage of supporting analyses over time.
Our data is less specific for the association between AD caregiving and adverse health effects in the spouse. We have no information on the degree of caregiving provided by each spouse or other informal or professional aides.
Additional research on the characteristics of spousal caregiving would better support our methodology, as would a system that allowed identification of a broader range of Medicare spousal beneficiaries. Nevertheless, spousal studies are possible with the available data. The observed emergence of elevated health service costs among spouses just before their partners’ AD diagnoses is a strong indicator that our methods for identification and matching have a rational basis.
The results constitute a thorough, coherent narrative on the interdependence of spouses’ and AD patients’ health. They show that reciprocal health effects are substantial and should be included in healthcare planning as the population becomes older and AD and other age-related conditions increase in prevalence. The study methodology additionally provides a framework for assessing the value of indirect as well as direct benefits of effective treatments. Further work will determine how useful this methodology is for other chronic, incapacitating diseases of the elderly.
Aging demographics and memory study
Beneficiary identification code
Claim account number
Centers for Medicare and Medicaid services
Health insurance claim number
International classification of diseases, ninth revision
JEN frailty index
Protected health information
Per Medicare beneficiary per month
This study was contracted by Eli Lilly and Company. The authors wish to thank David Gilden of JEN Associates for his editorial coordination and writing assistance.
- Alzheimer’s Association: 2013 Alzheimer’s disease facts and figures. Alzheimers Dement. 2013, 9 (2): 208-245.View ArticleGoogle Scholar
- McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, Thies B, Weintraub S, Phelps CH: The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011, 7 (3): 263-269. 10.1016/j.jalz.2011.03.005.View ArticlePubMedPubMed CentralGoogle Scholar
- Braaten AJ, Parsons TD, McCue R, Sellers A, Burns WJ: Neurocognitive differential diagnosis of dementing diseases: Alzheimer’s dementia, vascular dementia, frontotemporal dementia, and major depressive disorder. Int J Neurosci. 2006, 116 (11): 1271-1293. 10.1080/00207450600920928.View ArticlePubMedGoogle Scholar
- Rabins PV, Blacker D, Rovner BW, Rummans T, Schneider LS, Tariot PN, Blass DM, McIntyre JS, Charles SC, Anzia DJ, Cook IA, Finnerty MT, Johnson BR, Nininger JE, Schneidman B, Summergrad P, Woods SM, Berger J, Cross CD, Brandt HA, Margolis PM, Shemo JP, Blinder BJ, Duncan DL, Barnovitz MA, Carino AJ, Freyberg ZZ, APA Work Group on Alzheimer’s Disease and other Dementias, et al: American Psychiatric Association practice guideline for the treatment of patients with Alzheimer’s disease and other dementias. Second edition. Am J Psychiatry. 2007, 164 (12 Suppl): 5-56.PubMedGoogle Scholar
- Gaugler JE, Yu F, Krichbaum K, Wyman JF: Predictors of nursing home admission for persons with dementia. Med Care. 2009, 47 (2): 191-198. 10.1097/MLR.0b013e31818457ce.View ArticlePubMedGoogle Scholar
- Pinquart M, Sorensen S: Correlates of physical health of informal caregivers: a meta-analysis. J Gerontol B Psychol Sci Soc Sci. 2007, 62 (2): 126-137. 10.1093/geronb/62.2.P126.View ArticleGoogle Scholar
- Alzheimer’s Association: Families Care: Alzheimer’s Caregiving in the United States 2004. 2004, http://www.alz.org/national/documents/report_familiescare.pdf.Google Scholar
- Bloom BS, de Pouvourville N, Straus WL: Cost of illness of Alzheimer’s disease: how useful are current estimates?. Gerontologist. 2003, 43 (2): 158-164. 10.1093/geront/43.2.158.View ArticlePubMedGoogle Scholar
- Oremus M, Aguilar SC: A systematic review to assess the policy-making relevance of dementia cost-of-illness studies in the US and Canada. Pharmacoeconomics. 2011, 29 (2): 141-156. 10.2165/11539450-000000000-00000.View ArticlePubMedGoogle Scholar
- Christakis NA, Allison PD: Inter-spousal mortality effects: caregiver burden across the spectrum of disability disease. Health at Older Ages: The Causes and Consequences of Declining Disability among the Elderly. Edited by: Cutler DM, Wise DA. 2009, Chicago: University of Chicago Press, 455-477.View ArticleGoogle Scholar
- Zivin K, Christakis NA: The emotional toll of spousal morbidity and mortality. Am J Geriatr Psychiatry. 2007, 15 (9): 772-779. 10.1097/JGP.0b013e318050c9ae.View ArticlePubMedGoogle Scholar
- Taylor DHJ, Kuchibhatla M, Ostbye T: Trajectories of caregiving time provided by wives to their husbands with dementia. Alzheimer Dis Assoc Disord. 2008, 22 (2): 131-136. 10.1097/WAD.0b013e31815bebba.View ArticlePubMedPubMed CentralGoogle Scholar
- Holley CK, Mast BT: Predictors of anticipatory grief in dementia caregivers. Clin Gerontol. 2010, 33 (3): 223-236. 10.1080/07317111003793443.View ArticleGoogle Scholar
- Meuser TM, Marwit SJ: A comprehensive, stage-sensitive model of grief in dementia caregiving. Gerontologist. 2001, 41 (5): 658-670. 10.1093/geront/41.5.658.View ArticlePubMedGoogle Scholar
- Braekhus A, Oksengard AR, Engedal K, Laake K: Social and depressive stress suffered by spouses of patients with mild dementia. Scand J Prim Health Care. 1998, 16 (4): 242-246.PubMedGoogle Scholar
- Langa KM, Larson EB, Wallace RB, Fendrick AM, Foster NL, Kabeto MU, Weir DR, Willis RJ, Herzog AR: Out-of-pocket health care expenditures among older Americans with dementia. Alzheimer Dis Assoc Disord. 2004, 18 (2): 90-98. 10.1097/01.wad.0000126620.73791.3e.View ArticlePubMedGoogle Scholar
- Schulz R, Sherwood PR: Physical and mental health effects of family caregiving. Am J Nurs. 2008, 108 (9 Suppl): 23-27. quiz 27View ArticlePubMedPubMed CentralGoogle Scholar
- Vitaliano PP: An ironic tragedy: are spouses of persons with dementia at higher risk for dementia than spouses of persons without dementia?. J Am Geriatr Soc. 2010, 58 (5): 976-978. 10.1111/j.1532-5415.2010.02843.x.View ArticlePubMedPubMed CentralGoogle Scholar
- Kim Y, Schulz R: Family caregivers’ strains: comparative analysis of cancer caregiving with dementia, diabetes, and frail elderly caregiving. J Aging Health. 2008, 20 (5): 483-503. 10.1177/0898264308317533.View ArticlePubMedGoogle Scholar
- Kolanowski AM, Fick D, Waller JL, Shea D: Spouses of persons with dementia: their healthcare problems, utilization, and costs. Res Nurs Health. 2004, 27 (5): 296-306. 10.1002/nur.20036.View ArticlePubMedGoogle Scholar
- Moore MJ, Zhu CW, Clipp EC: Informal costs of dementia care: estimates from the National Longitudinal Caregiver Study. J Gerontol B Psychol Sci Soc Sci. 2001, 56 (4): S219-S228. 10.1093/geronb/56.4.S219.View ArticlePubMedGoogle Scholar
- Suehs BT, Shah SN, Davis CD, Alvir J, Faison WE, Patel NC, van Amerongen D, Bobula J: Household members of persons with Alzheimer’s disease: health conditions, healthcare resource use, and healthcare costs. J Am Geriatr Soc. 2014, 62 (3): 435-441. 10.1111/jgs.12694.View ArticlePubMedGoogle Scholar
- Hebert LE, Weuve J, Scherr PA, Evans DA: Alzheimer disease in the United States (2010–2050) estimated using the 2010 census. Neurology. 2013, 80 (19): 1778-1783. 10.1212/WNL.0b013e31828726f5.View ArticlePubMedPubMed CentralGoogle Scholar
- Merriman K, Asper FM: ResDAC Publication Number TN-011. Differences in how the Medicare 5% files are generated. 2007, Minneapolis, MN: Research Data Assistance Center, University of Minnesota School of Public HealthGoogle Scholar
- Asper F, Mann E: Medicare Managed Care Enrollees and the Medicare Utilization Files. 114. 2013, Minneapolis, MN: Research Data Assistance Center, http://www.resdac.org/resconnect/articles/114.Google Scholar
- Iwashyna TJ, Brennan G, Zhang JX, Christakis NA: Finding married couples in Medicare claims data. Health Serv Outcomes Res. 2002, 3 (1): 75-86. 10.1023/A:1021535025363.View ArticleGoogle Scholar
- Iwashyna TJ, Zhang JX, Lauderdale DS, Christakis NA: A methodology for identifying married couples in Medicare data: mortality, morbidity, and health care use among the married elderly. Demography. 1998, 35 (4): 413-419. 10.2307/3004010.View ArticlePubMedGoogle Scholar
- Charlson ME, Pompei P, Ales KL, MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987, 40 (5): 373-383. 10.1016/0021-9681(87)90171-8.View ArticlePubMedGoogle Scholar
- Deyo RA, Cherkin DC, Ciol MA: Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol. 1992, 45 (6): 613-619. 10.1016/0895-4356(92)90133-8.View ArticlePubMedGoogle Scholar
- Bratesman S, Saucier P: Applying Managed Fee-for-Service Delivery Models to Improve Care for Dually Eligible Beneficiaries. 12. 2002, College Park, MD: University of Maryland Center on Aging, Medicare/Medicaid Integration Program, http://muskie.usm.maine.edu/Publications/ihp/MFFS&DualEligibility.pdf.Google Scholar
- Rao S, Kubisiak J, Gilden D: Cost of illness associated with metastatic breast cancer. Breast Cancer Res Treat. 2004, 83 (1): 25-32. 10.1023/B:BREA.0000010689.55559.06.View ArticlePubMedGoogle Scholar
- Gilden DM, Kubisiak J, Zbrozek AS: The economic burden of Medicare-eligible patients by multiple sclerosis type. Value Health. 2011, 14 (1): 61-69. 10.1016/j.jval.2010.10.022.View ArticlePubMedGoogle Scholar
- Gilden D, Kubisiak J, Kahle-Wrobleski K, Ball D, Bowman L: Spouses of Patients with Alzheimer Disease: Health Care Costs and Implications. 2011, Paris, France: Alzheimer’s Association International Conference, http://www.indydiscoverynetwork.org/Presentations.html.Google Scholar
- United States Census Bureau: Census 2000 Summary File 4 (SF 4) – Sample Data. Table PCT035: sex by marital status by age for the population 15 years and over. http://factfinder2.census.gov/faces/tableservices/jsf/pages/productview.xhtml?.
- Chiu E: Limitations in the current classification systems for dementia. Int Psychogeriatr. 2005, 17 (Suppl 1): S17-S26.View ArticlePubMedGoogle Scholar
- Centers for Medicare and Medicaid Services: Transmittal AB-01-135. Medical Review of Services for Patients with Dementia: Change Request 1793. 2001, http://www.cms.gov/Regulations-and-Guidance/Guidance/Transmittals/downloads/AB-01-135.pdf.Google Scholar
- Fillit H, Geldmacher DS, Welter RT, Maslow K, Fraser M: Optimizing coding and reimbursement to improve management of Alzheimer’s disease and related dementias. J Am Geriatr Soc. 2002, 50 (11): 1871-1878. 10.1046/j.1532-5415.2002.50519.x.View ArticlePubMedGoogle Scholar
- Taylor DHJ, Ostbye T, Langa KM, Weir D, Plassman BL: The accuracy of Medicare claims as an epidemiological tool: the case of dementia revisited. J Alzheimers Dis. 2009, 17 (4): 807-815.PubMedPubMed CentralGoogle Scholar
- Lin PJ, Kaufer DI, Maciejewski ML, Ganguly R, Paul JE, Biddle AK: An examination of Alzheimer’s disease case definitions using Medicare claims and survey data. Alzheimers Dement. 2010, 6 (4): 334-341. 10.1016/j.jalz.2009.09.001.View ArticlePubMedGoogle Scholar
- Bharmal MF, Weiner M, Sands LP, Xu H, Craig BA, Thomas J: Impact of patient selection criteria on prevalence estimates and prevalence of diagnosed dementia in a Medicaid population. Alzheimer Dis Assoc Disord. 2007, 21 (2): 92-100. 10.1097/WAD.0b013e31805c0835.View ArticlePubMedGoogle Scholar
- Wilson RS, Weir DR, Leurgans SE, Evans DA, Hebert LE, Langa KM, Plassman BL, Small BJ, Bennett DA: Sources of variability in estimates of the prevalence of Alzheimer’s disease in the United States. Alzheimers Dement. 2011, 7 (1): 74-79. 10.1016/j.jalz.2010.11.006.View ArticlePubMedPubMed CentralGoogle Scholar
- Sanders S, Corley CS: Are they grieving? A qualitative analysis examining grief in caregivers of individuals with Alzheimer’s disease. Soc Work Health Care. 2003, 37 (3): 35-53. 10.1300/J010v37n03_03.View ArticlePubMedGoogle Scholar
- Schulz R, Martire LM: Family caregiving of persons with dementia: prevalence, health effects, and support strategies. Am J Geriatr Psychiatry. 2004, 12 (3): 240-249. 10.1097/00019442-200405000-00002.View ArticlePubMedGoogle Scholar
- Wolff JL, Kasper JD: Caregivers of frail elders: updating a national profile. Gerontologist. 2006, 46 (3): 344-356. 10.1093/geront/46.3.344.View ArticlePubMedGoogle Scholar
- Schulz R, Newsom J, Mittelmark M, Burton L, Hirsch C, Jackson S: Health effects of caregiving: the caregiver health effects study: an ancillary study of the cardiovascular health study. Ann Behav Med. 1997, 19 (2): 110-116. 10.1007/BF02883327.View ArticlePubMedGoogle Scholar
- Schulz R, Williamson GM: The measurement of caregiver outcomes in Alzheimer disease research. Alzheimer Dis Assoc Disord. 1997, 11 (Suppl 6): 117-124.PubMedGoogle Scholar
- Brown SL, Smith DM, Schulz R, Kabeto MU, Ubel PA, Poulin M, Yi J, Kim C, Langa KM: Caregiving behavior is associated with decreased mortality risk. Psychol Sci. 2009, 20 (4): 488-494. 10.1111/j.1467-9280.2009.02323.x.View ArticlePubMedPubMed CentralGoogle Scholar
- Schulz R, Beach SR: Caregiving as a risk factor for mortality: the caregiver health effects study. JAMA. 1999, 282 (23): 2215-2219. 10.1001/jama.282.23.2215.View ArticlePubMedGoogle Scholar
- Elwert F, Christakis NA: The effect of widowhood on mortality by the causes of death of both spouses. Am J Public Health. 2008, 98 (11): 2092-2098. 10.2105/AJPH.2007.114348.View ArticlePubMedPubMed CentralGoogle Scholar
- Norton MC, Smith KR, Ostbye T, Tschanz JT, Corcoran C, Schwartz S, Piercy KW, Rabins PV, Steffens DC, Skoog I, Breitner JC, Welsh-Bohmer KA, Cache County Investigators: Greater risk of dementia when spouse has dementia? The cache county study. J Am Geriatr Soc. 2010, 58 (5): 895-900. 10.1111/j.1532-5415.2010.02806.x.View ArticlePubMedPubMed CentralGoogle Scholar
- Norton MC, Piercy KW, Rabins PV, Green RC, Breitner JC, Ostbye T, Corcoran C, Welsh-Bohmer KA, Lyketsos CG, Tschanz JT: Caregiver-recipient closeness and symptom progression in Alzheimer disease. The cache county dementia progression study. J Gerontol B Psychol Sci Soc Sci. 2009, 64 (5): 560-568.View ArticlePubMedGoogle Scholar
- Bigatti SM, Cronan TA: An examination of the physical health, healthcare use, and psychological well-being of spouses of people with fribromyalgia syndrome. Health Psychol. 2002, 21 (2): 157-166.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6963/14/291/prepub
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