Navigating veterans with an abnormal prostate cancer screening test: a quasi-experimental study
- Melissa A Simon†1, 2Email author,
- Narissa J Nonzee†1, 2, 3,
- June M McKoy1, 2,
- Dachao Liu1, 2, 3,
- Thanh Ha Luu4,
- Peter Byer1, 3,
- Elizabeth A Eklund1, 2, 3,
- Elizabeth A Richey5,
- Zhigang Wu3, 6,
- XinQi Dong4 and
- Alfred W Rademaker1, 2
© Simon et al.; licensee BioMed Central Ltd. 2013
Received: 4 March 2013
Accepted: 3 August 2013
Published: 15 August 2013
Prostate cancer disproportionately affects low-income and minority men. This study evaluates the impact of a patient navigation intervention on timeliness of diagnostic resolution and treatment initiation among veterans with an abnormal prostate cancer screen.
Participants were enrolled between 2006 and 2010. The intervention involved a social worker and lay health worker navigation team that assisted patients in overcoming barriers to care. For navigated (n = 245) versus control (n = 245) participants, we evaluated rates of diagnostic resolution and treatment and adjusted for race, age, and Gleason score.
Of 490 participants, 68% were African American, 47% were ≥ 65 years old, and 35% had cancer. Among those with an abnormal screen, navigation did not have a significant effect on time to diagnostic resolution compared to controls (median days of 97 versus 111; adj. HR 1.17, 95% CI, 0.96-1.43, p = 0.12). On analysis of the period beyond 80 days, navigated men reached resolution faster than controls (median of 151 days versus 190 days; adj. HR 1.41, 95% CI, 1.07-1.86, p = 0.01). Among those with cancer, navigation did not have a significant effect on time to treatment initiation compared to controls (median of 93 days versus 87 days; adj. HR 1.15, 95% CI, 0.82-1.62, p = 0.41).
Our navigation program did not significantly impact the overall time to resolution or treatment for men with prostate cancer compared to controls. The utility of navigation programs may extend beyond targeted navigation times, however, and future studies focusing on other outcomes measures are therefore needed.
Prostate cancer accounts for 28% of newly diagnosed cancers and is the second leading cause of cancer-related deaths among men in the United States . Although prostate cancer screening remains controversial, five-and ten-year relative survival rates are highly favorable if prostate cancer is detected early . Over the past 20 years, prostate cancer death rates have declined considerably, but progress has not been equally shared among all populations . In particular, low-income men have increased risk of distant-stage prostate cancer , and African Americans have the highest prostate cancer mortality rate of any racial or ethnic group in the U.S. .
Multiple factors have been associated with delayed prostate cancer diagnosis, including health care system and physician distrust [5, 6], lower household incomes , cancer misinformation , provider failure to facilitate timely follow-up , and culturally-influenced resistance to digital rectal examination (DRE) . Patient navigation, a patient-centered intervention seeking to remove barriers to timely healthcare services , is one possible strategy for improving cancer outcomes–particularly among historically disadvantaged populations. In the 1990s, Dr. Harold Freeman established the first patient navigation program for low-income minority women in Harlem, New York. The findings suggested that navigation may increase rates and timeliness of diagnostic resolution following an abnormal breast cancer screening finding . Based on the promising benefits of this model, the National Cancer Institute’s (NCI) Center to Reduce Cancer Health Disparities (CRCHD) and American Cancer Society (ACS) funded nine sites for the Patient Navigation Research Program (PNRP) , the first multi-center study to critically examine and demonstrate the efficacy of navigation [14–19].
Most navigation programs have emerged in outpatient clinical settings and have focused on breast, cervical, or colorectal cancer; few have reported on prostate cancer outcomes [11, 20–25]. Only one nurse navigation program has evaluated time to treatment initiation at a Veterans Affairs (VA) hospital, but used historical controls and found it challenging to isolate the effects of navigation from other systems changes simultaneously implemented within a larger VA process improvement project . One combined prostate cancer education and navigator program demonstrated increased prostate cancer screening rates among African Americans , and a PNRP site reported navigation’s effect on diagnostic resolution of a prostate screening abnormality . In the Chicago PNRP, we uniquely implemented a navigation intervention among predominantly low-income and minority men at a VA, where access to care barriers are diminished. We evaluated time to diagnostic resolution and treatment initiation among navigated versus control patients with an abnormal prostate cancer screen.
The study took place at a Chicago VA, an equal access system in an urban medical district. The tertiary care facility and its four community-based outpatient clinics provide care to approximately 58,000 veterans in Chicago, the county (Cook) in which Chicago resides, and six counties in northwestern Indiana. A large proportion of veterans in Illinois are African American, and nearly half in Cook County are over age 65 .
Our protocol has been described in detail previously . Briefly, the study used a quasi-experimental design. Eligible patients were identified through electronic medical records. Patients were selected to receive navigation if they met inclusion criteria and presented to the urology clinic on a clinic day designated for the navigation intervention (n = 245). All patients who presented on a clinic day designated for non-navigation and met inclusion criteria were identified as controls. Control subjects received usual care and comprised a consecutive and concurrent records-based sample with a one-to-one match goal (n = 245). The clinic was staffed with rotating resident physicians and stable supervising attending physicians and nurses who remained constant across navigated and non-navigated clinic days.
Eligibility and recruitment
Our study enrolled patients from November 2006 through April 2010. All patients who presented to the VA urology clinic for follow-up of an abnormal prostate cancer screening test (prostate specific antigen (PSA) ≥ 4.0 ng/mL, PSA < 4.0 ng/mL with an abnormal PSA velocity defined by a physician, or abnormal DRE) and who were recommended for a biopsy were eligible. We excluded patients if they were less than age 18, institutionalized, cognitively impaired, previously navigated for an abnormal cancer finding, or treated for any cancer except non-melanoma cancer within the past five years. Our study team approached patients for participation following provider referral on the first follow-up visit in the urology clinic. We obtained written informed consent from navigated patients, and the Institutional Review Board (IRB) granted a waiver of authorization for our control sample. The Northwestern University IRB, Jesse Brown VA Medical Center, and the Collaborative IRB at the University of Illinois at Chicago approved the study.
The patient navigation team comprised two full-time male navigators: one social worker and one lay health worker . Navigators participated in local training, monthly state-level ACS trainings, and national annual PNRP training conferences relative to navigator roles, health disparities, cancer knowledge, cultural diversity, and communication .
Upon enrollment, navigators conducted face-to-face interviews with patients to identify potential barriers to care, and follow-up assistance occurred in person or over the phone until diagnostic resolution for those without prostate cancer, primary therapy completion for those with cancer, or until the end of the study. The number of contacts varied according to need, but at minimum, each patient received appointment reminder calls one month and ten days prior to his scheduled biopsy appointment to ensure compliance with preparatory instructions . Additional navigation activities included social support, facilitation of patient-provider communication, transportation coordination, and patient education. Navigators also often accompanied patients with prostate cancer to treatment appointments and connected each with a cancer survivor through an established ACS program.
We collected self-reported demographic data at baseline in the navigated arm and obtained them through chart audit in the control arm. Navigators documented each encounter, barrier, and action taken on standardized tracking logs developed based on the needs assessment of our targeted population. Our needs assessment involved interviews with key hospital staff and patients who delayed abnormal screen follow-up and focused on identification of personal and system barriers to care . Using the VA's comprehensive computerized patient record system, trained research assistants performed chart audits for clinical outcomes data following national PNRP guidelines . Teams of researchers (N.N., P.B., T.L., and E.R.) independently abstracted data on a subset of the entire sample and iteratively compared results until they achieved consistent agreement; clinical co-investigators (M.S. and J.M.) adjudicated discrepancies. The project and data managers thoroughly reviewed data completeness and cleaned entry errors on a quarterly basis.
The primary outcome for the prostate screening group was time from abnormal screening test to diagnostic resolution (Time 1). For the prostate cancer diagnosis group, the primary outcome was time from diagnostic resolution to treatment initiation (Time 2). These events had to occur before 365 days from abnormal screen for Time 1 or 365 days from diagnosis for Time 2 to be considered events in the statistical analysis. Otherwise, they were censored at 365 days. Abnormal screening was defined as the date of the abnormal prostate screening test (PSA or DRE) prompting referral for follow-up, and definitive diagnosis was defined as the date of the diagnostic test (transrectal ultrasound (TRUS)-guided biopsy or follow-up PSA test) resolving the screening test into a cancer diagnosis or non-cancer diagnosis (negative biopsy on pathology or normal PSA level/velocity for those who resolved with a follow-up PSA test). Treatment initiation was defined as the first date of treatment receipt with single or combination therapy (surgery, radiation, hormonal therapy, cryotherapy, or decision to watch and wait).
Based on preliminary data and our group’s clinical experience with veterans with prostate cancer, we estimated that the mean time from abnormal screen to diagnostic resolution (Time 1) in the control group would be 103 days, and the mean time from cancer diagnosis to treatment initiation (Time 2) in cancer patients would be 128 days. The initial power calculation indicated that for Time 1, 300 patients per group would have 80% power to detect a mean Time 1 of 86 days in the navigated group, and that 120 cancer patients per group would have 80% power to detect a mean Time 2 of 90 days in the navigated group. Since only 245 instead of 300 patients were enrolled per group for Time 1, the actual effect size for Time 1 that was detectable with 80% power was 103 days versus 84 days. Since only 85 instead of 120 patients were enrolled per group for Time 2, the actual effect size for Time 2 that was detectable with 80% power was 128 days versus 82 days. Two-tailed tests and a Type I error rate of 5% were assumed.
All statistical analyses were conducted using SAS version 9.2 (SAS Institute, Inc., Cary, North Carolina) . For categorical variables, frequencies and percentages were calculated by group and for the whole sample. Comparisons between groups were made using Fisher’s exact test. Unadjusted and adjusted time-to-event analyses were done for Time 1 and Time 2. For unadjusted analyses, Kaplan-Meier curves were calculated, median times (25th percentile for one analysis since the median was not attained) within groups were determined from these curves, and curves were compared between groups using the log-rank test. For adjusted analyses, proportional hazards regression was used. The proportional hazards assumption was assessed by inclusion of a group by log-time interaction term. For Time 1, age (< 65, ≥ 65), and race (African American, non-African American) were used as covariates. Baseline absolute PSA value was not included in the model, as nearly one-fifth of patients were eligible based on an abnormal DRE or PSA velocity. For Time 2, age (< 65, ≥ 65), race (African American, non-African American), and total Gleason score (≤ 6, > 6) were used as covariates. Adjusted hazard ratios (HR) and 95% confidence intervals are reported, together with a p-value testing whether the HR was 1.0. A HR greater than 1 indicated that the outcome occurred earlier in the navigated group compared with the control group. A HR less than 1 indicated that the outcome occurred later in the navigated group compared with the control group. Kaplan-Meier curves showed a crossover time point, an indication that the proportional hazards assumption might be violated; thus, time to event was analyzed separately before the cross-over period in each analysis. A significant group by log-time interaction (p = 0.0009) indicated the proportional hazards assumption did not hold for Time 1. For Time 1, navigated and control groups were then compared (a) using all participants in the analysis and censoring everyone with a follow-up time greater than 80 days and (b) using only those participants with follow-up greater than 80 days. The proportional hazards assumption did hold for Time 2. For Time 2, navigated and control groups were compared within subgroups determined by: (a) Gleason score (≤ 6 vs. > 6); (b) treatment type; and (c) receipt of consultation beyond a urologist, given that multiple specialist visits could delay treatment initiation.
Patient characteristics, all subjects (N = 490)
Navigated (N = 245)
Control (N = 245)
< 65 years old
≥ 65 years old
Comorbidities (CCI Score)
PSA test (≥ 4.0 ng/mL)
Abnormal PSA velocity
< 4 ng/mLa
4 ng/mL - 10 ng/mL
> 10 ng/mL
Missing (Eligible by DRE)
No cancer/resolved with PSA test
Patient characteristics, subjects with cancer (N = 170)
Navigated (N = 84)
Control (N = 86)
< 65 years old
≥ 65 years old
≤ 3 + 3
> 3 + 3
Consultation beyond Urology a
External Radiation Therapy
Interstitial Radiation Therapy
Treatment not initiated
Time to diagnostic resolution
Among our total sample, 85% reached a diagnostic resolution (50% with a negative resolution based on a negative biopsy or repeat PSA test; 35% with a positive diagnosis) (Table 1). Seventy-six (16%) were unresolved (Figure 1). Resolution rates were comparable between the study groups.
Summary of analyses of time to diagnostic resolution (Time 1) and time to treatment initiation (Time 2)
Log rank p-value
Adj. 95% C.I.
Time 1: Time from abnormal screening to diagnostic resolution
Time 1 stratified by diagnostic resolution time interval
0.67 – 1.23
1.07 - 1.86
Time 2: Time from diagnostic resolution to treatment initiation
Time 2 overall
0.82 - 1.62
In the analysis of Time 1 by race (African American, White), outcomes were similar to overall results. Prior to 80 days, the 25th percentile of the time to diagnostic resolution was similar in the navigated and control groups within each racial group (data not shown). Beyond 80 days, the median time to diagnostic resolution was shorter among the navigated group within each racial group, and significant among White participants (median of 122 days versus 179 days, p = 0.047).
Time to treatment initiation
In the analysis of Time 2 by race (African American, White), results were similar to the overall results: no navigated-control differences in time to treatment initiation were observed within either race group. In addition, we found no difference in navigated versus control group median days to treatment initiation with respect to Gleason score or consultation beyond a urologist (data not shown). With respect to treatment types, no difference was observed except among men whose primary therapy was radiation, where time to treatment initiation was significantly lower for navigated versus control group participants (median of 95 days versus 120 days, p = 0.05).
In our study, we found no overall effect of patient navigation on time to diagnostic resolution or time to treatment initiation among veterans with an abnormal prostate cancer screening test or cancer diagnosis, respectively, regardless of race.
Several possible explanations for our findings exist. First, our intervention may have missed the crucial time point to begin navigation. In a randomized navigation trial based at public hospitals, Bastani et al. found that women who missed their first appointment following an abnormal breast screening had no chance of timely diagnostic resolution . She posited that clinic staff may have been more invested in ensuring that women who kept their first appointment understood the follow-up process, resulting in better appointment adherence downstream. Men in our study had already kept their first follow-up appointment in the urology clinic, the first opportunity presented to obtain written informed consent, which may have similarly accounted for the absence of overall navigation effect. Our VA also included other well-established support mechanisms, such as the urology clinic nurse practitioner who provided prostate cancer education and volunteer clinic staff who performed appointment reminders. Finally, though we anticipated gender-matched navigation would facilitate communication, male patients have demonstrated less receptivity to social support in the clinical setting than women , which additionally could have diminished the intervention’s effect.
Though the overall finding for time to resolution was negative, navigated patients who did not reach diagnostic resolution within the first 80-day period resolved their screening test faster than controls. This shortened time may be attributed to factors inherent to navigation: the establishment of trust, access to education and information, and decreased anxiety. Men who delay diagnostic resolution beyond a 3-month period may merit outreach via patient navigation. In subgroup analyses among participants with prostate cancer, navigated men whose primary therapy was radiation had a shorter time to treatment than controls. Further research to better delineate the navigators’ role in supporting men through the complex treatment decision making process is needed.
Study limitations include, first, a lack of individual randomization to participate in navigation. We initially planned to implement the program at two similar VA outpatient centers, one designated as the navigation site and the other as the control site; however, a hospital merger just prior to accrual made this design logistically unfeasible. We ultimately chose to assign navigation based on clinic day to allow for minimal disruption to patient care during clinic reconfiguration and to reduce contamination between study arms at the single clinic site. While enrolling navigated patients and contemporaneous controls on designated clinic days could lead to selection bias, all patients were selected from the same clinic at one VA location and cared for by physicians with similar practice patterns. Second, we acknowledge that the differences in race between our control and navigated groups may have been due to use of administrative data versus self-reported race/ethnicity data, respectively, in each arm—two different methods showing low agreement in other VA studies [35, 36]. Third, our findings may not be generalizabile to non-VA hospitals and non-VA male populations. Fourth, our outcome measures focused on time may not have targeted the true value of prostate cancer navigation. Finally, referral bias remains a concern, since patients referred to a study tend to be more motivated about their health.
Despite limitations, this study is the first controlled navigation intervention that elucidates prostate cancer outcomes at a VA. The Denver PNRP implemented their intervention in an integrated safety-net health care system and found that prostate cancer navigation shortened time to diagnostic resolution, with borderline significant results attributed to a small sample size and potential reduced screening practice among older age groups . By contrast, our VA routinely screened veterans including older men and those with chronically elevated PSA tests, which may have conferred less urgency to fast-track them through the referral process. Furthermore, insufficient evidence supporting negative long-term effects of diagnostic or treatment delays on biochemical progression [37, 38] or survival  could have also reduced urgency within our cancer group.
In summary, our study indicated that patient navigation did not significantly reduce time to diagnostic resolution among men with an abnormal prostate cancer screen or treatment initiation among men with prostate cancer. Targeting patients who miss their first follow-up appointment after identification of abnormal finding may have more optimally impacted time-related outcomes. Notably, prostate cancer is the second most frequently diagnosed cancer among American men yet holds the most controversial track record for screening and has a range of treatment options, including the choice to not pursue treatment. It is therefore imperative that emerging navigation programs consider their impact on additional parameters beyond timelier care, such as quality of life and treatment decision making, to address prostate cancer disparities.
Digital rectal exam
National Cancer Institute
American Cancer Society
Patient Navigation Research Program
Prostate specific antigen
Institutional Review Board
Charlson Comorbidity Index.
We thank the Chicago VA nurses, physicians, staff, and especially our Veteran participants. The guidance from Drs. Steven Rosen and Charles Bennett, efforts from our patient navigators and community advisory board, and data management by Samie Martinez are also gratefully acknowledged.
This work was supported by National Institutes of Health (NIH)/National Cancer Institute (NCI) U01 CA116875 (Rosen), Veterans Affairs Research and Development, NIH/National Institute of Child Health & Human Development K12 HD050121 (Bulun), NIH/NCI K01 CA134554 (McKoy), and NIH/NCI P30 CA060553 (Rosen).
- Siegel R, Naishadham D, Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 2013, 63 (1): 11-30. 10.3322/caac.21166.View ArticlePubMedGoogle Scholar
- Siegel R, DeSantis C, Virgo K, Stein K, Mariotto A, Smith T, Cooper D, Gansler T, Lerro C, Fedewa S, et al: Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin. 2012, 62 (4): 220-241. 10.3322/caac.21149.View ArticlePubMedGoogle Scholar
- Clegg LX, Reichman ME, Miller BA, Hankey BF, Singh GK, Lin YD, Goodman MT, Lynch CF, Schwartz SM, Chen VW, et al: Impact of socioeconomic status on cancer incidence and stage at diagnosis: selected findings from the surveillance, epidemiology, and end results: national longitudinal mortality study. Cancer Causes Control. 2009, 20 (4): 417-435. 10.1007/s10552-008-9256-0.View ArticlePubMedGoogle Scholar
- Howlader N, Noone AM, Krapcho M, Neyman N, Aminou R, Altekruse SF, Kosary CL, Ruhl J, Tatalovich Z, Cho H, Howlader N, Noone AM, Krapcho M, Neyman N, Aminou R, Altekruse SF, Kosary CL, Ruhl J, Tatalovich Z, Cho H, et al: SEER Cancer Statistics Review, 1975-2010. 2012, [http://seer.cancer.gov/csr/1975_2010/]Google Scholar
- Talcott JA, Spain P, Clark JA, Carpenter WR, Do YK, Hamilton RJ, Galanko JA, Jackman A, Godley PA: Hidden barriers between knowledge and behavior: the North Carolina prostate cancer screening and treatment experience. Cancer. 2007, 109 (8): 1599-1606. 10.1002/cncr.22583.View ArticlePubMedGoogle Scholar
- Pedersen VH, Armes J, Ream E: Perceptions of prostate cancer in Black African and Black Caribbean men: a systematic review of the literature. Psychooncology. 2012, 21 (5): 457-468. 10.1002/pon.2043.View ArticlePubMedGoogle Scholar
- Xiao H, Tan F, Goovaerts P: Racial and geographic disparities in late-stage prostate cancer diagnosis in Florida. J Health Care Poor Underserved. 2011, 22 (4 Suppl): 187-199.View ArticlePubMedPubMed CentralGoogle Scholar
- Richardson JT, Webster JD, Fields NJ: Uncovering myths and transforming realities among low-SES African-American men: implications for reducing prostate cancer disparities. J Natl Med Assoc. 2004, 96 (10): 1295-1302.PubMedPubMed CentralGoogle Scholar
- Nepple KG, Joudi FN, Hillis SL, Wahls TL: Prevalence of delayed clinician response to elevated prostate-specific antigen values. Mayo Clin Proc. 2008, 83 (4): 439-445. 10.4065/83.4.439.View ArticlePubMedGoogle Scholar
- Blocker DE, Romocki LS, Thomas KB, Jones BL, Jackson EJ, Reid L, Campbell MK: Knowledge, beliefs and barriers associated with prostate cancer prevention and screening behaviors among African-American men. J Natl Med Assoc. 2006, 98 (8): 1286-1295.PubMedPubMed CentralGoogle Scholar
- Wells KJ, Battaglia TA, Dudley DJ, Garcia R, Greene A, Calhoun E, Mandelblatt JS, Paskett ED, Raich PC: Patient navigation: state of the art or is it science?. Cancer. 2008, 113 (8): 1999-2010. 10.1002/cncr.23815.View ArticlePubMedPubMed CentralGoogle Scholar
- Freeman HP, Muth BJ, Kerner JF: Expanding access to cancer screening and clinical follow-up among the medically underserved. Cancer Pract. 1995, 3 (1): 19-30.PubMedGoogle Scholar
- Freund KM, Battaglia TA, Calhoun E, Dudley DJ, Fiscella K, Paskett E, Raich PC, Roetzheim RG: National cancer institute patient navigation research program: methods, protocol, and measures. Cancer. 2008, 113 (12): 3391-3399. 10.1002/cncr.23960.View ArticlePubMedPubMed CentralGoogle Scholar
- Battaglia TA, Bak SM, Heeren T, Chen CA, Kalish R, Tringale S, Taylor JO, Lottero B, Egan AP, Thakrar N, et al: Boston patient navigation research program: the impact of navigation on time to diagnostic resolution after abnormal cancer screening. Cancer Epidemiol Biomarkers Prev. 2012, 21 (10): 1645-1654. 10.1158/1055-9965.EPI-12-0532.View ArticlePubMedPubMed CentralGoogle Scholar
- Dudley DJ, Drake J, Quinlan J, Holden A, Saegert P, Karnad A, Ramirez A: Beneficial effects of a combined navigator/promotora approach for Hispanic women diagnosed with breast abnormalities. Cancer Epidemiol Biomarkers Prev. 2012, 21 (10): 1639-1644. 10.1158/1055-9965.EPI-12-0538.View ArticlePubMedPubMed CentralGoogle Scholar
- Hoffman HJ, LaVerda NL, Young HA, Levine PH, Alexander LM, Brem R, Caicedo L, Eng-Wong J, Frederick W, Funderburk W, et al: Patient navigation significantly reduces delays in breast cancer diagnosis in the District of Columbia. Cancer Epidemiol Biomarkers Prev. 2012, 21 (10): 1655-1663. 10.1158/1055-9965.EPI-12-0479.View ArticlePubMedGoogle Scholar
- Markossian TW, Darnell JS, Calhoun EA: Follow-up and timeliness after an abnormal cancer screening among underserved, urban women in a patient navigation program. Cancer Epidemiol Biomarkers Prev. 2012, 21 (10): 1691-1700. 10.1158/1055-9965.EPI-12-0535.View ArticlePubMedPubMed CentralGoogle Scholar
- Paskett ED, Katz ML, Post DM, Pennell ML, Young GS, Seiber EE, Harrop JP, DeGraffinreid CR, Tatum CM, Dean JA, et al: The Ohio patient navigation research program: does the American cancer society patient navigation model improve time to resolution in patients with abnormal screening tests?. Cancer Epidemiol Biomarkers Prev. 2012, 21 (10): 1620-1628. 10.1158/1055-9965.EPI-12-0523.View ArticlePubMedPubMed CentralGoogle Scholar
- Raich PC, Whitley EM, Thorland W, Valverde P, Fairclough D: Patient navigation improves cancer diagnostic resolution: an individually randomized clinical trial in an underserved population. Cancer Epidemiol Biomarkers Prev. 2012, 21 (10): 1629-1638. 10.1158/1055-9965.EPI-12-0513.View ArticlePubMedPubMed CentralGoogle Scholar
- Paskett ED, Harrop JP, Wells KJ: Patient navigation: an update on the state of the science. CA Cancer J Clin. 2011, 61 (4): 237-249. 10.3322/caac.20111.View ArticlePubMedPubMed CentralGoogle Scholar
- Percac-Lima S, Benner CS, Lui R, Aldrich LS, Oo SA, Regan N, Chabner BA: The impact of a culturally tailored patient navigator program on cervical cancer prevention in Latina women. J Womens Health (Larchmt). 2013, 22 (5): 426-431. 10.1089/jwh.2012.3900.View ArticleGoogle Scholar
- Haideri NA, Moormeier JA: Impact of patient navigation from diagnosis to treatment in an urban safety net breast cancer population. J Cancer. 2011, 2: 467-473.View ArticlePubMedPubMed CentralGoogle Scholar
- Jandorf L, Braschi C, Ernstoff E, Wong CR, Thelemaque LD, Winkel G, Thompson H, Redd WH, Itzkowitz S: Culturally targeted patient navigation for increasing African American’s adherence to screening colonoscopy: a randomized clinical trial. in press
- Braschi CD, Sly JR, Singh S, Villagra C, Jandorf L: Increasing colonoscopy screening for Latino Americans through a patient navigation model: a randomized clinical trial. J Immigr Minor Health. in press
- Lasser KE, Murillo J, Lisboa S, Casimir AN, Valley-Shah L, Emmons KM, Fletcher RH, Ayanian JZ: Colorectal cancer screening among ethnically diverse, low-income patients: a randomized controlled trial. Arch Intern Med. 2011, 171 (10): 906-912. 10.1001/archinternmed.2011.201.View ArticlePubMedGoogle Scholar
- Alsamarai S, Yao X, Cain HC, Chang BW, Chao HH, Connery DM, Deng Y, Garla VN, Hunnibell LS, Kim AW, et al: The effect of a lung cancer care coordination program on timeliness of care. Clin Lung Cancer. in press
- Weinrich SP, Boyd MD, Weinrich M, Greene F, Reynolds WA, Metlin C: Increasing prostate cancer screening in African American men with peer-educator and client-navigator interventions. J Cancer Educ. 1998, 13 (4): 213-219.PubMedGoogle Scholar
- U.S. Department of Veterans Affairs: National center for veterans analysis and statistics. 2011, [http://www.va.gov/vetdata/]Google Scholar
- Nonzee NJ, McKoy JM, Rademaker AW, Byer P, Luu TH, Liu D, Richey EA, Samaras AT, Panucci G, Dong X, et al: Design of a prostate cancer patient navigation intervention for a veterans affairs hospital. BMC Health Services Res. 2012, 12: 340-10.1186/1472-6963-12-340.View ArticleGoogle Scholar
- Calhoun EA, Whitley EM, Esparza A, Ness E, Greene A, Garcia R, Valverde PA: A national patient navigator training program. Health Promot Pract. 2010, 11 (2): 205-215. 10.1177/1524839908323521.View ArticlePubMedGoogle Scholar
- SAS Version 9.2. 2008, Cary, N.C: SAS Institute Inc
- Charlson ME, Pompei P, Ales KL, MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987, 40 (5): 373-383. 10.1016/0021-9681(87)90171-8.View ArticlePubMedGoogle Scholar
- Bastani R, Mojica CM, Berman BA, Ganz PA: Low-income women with abnormal breast findings: results of a randomized trial to increase rates of diagnostic resolution. Cancer Epidemiol Biomarkers Prev. 2010, 19 (8): 1927-1936. 10.1158/1055-9965.EPI-09-0481.View ArticlePubMedGoogle Scholar
- Harrison J, Maguire P, Pitceathly C: Confiding in crisis: gender differences in pattern of confiding among cancer patients. Soc Sci Med. 1995, 41 (9): 1255-1260. 10.1016/0277-9536(94)00411-L.View ArticlePubMedGoogle Scholar
- Kressin NR, Chang BH, Hendricks A, Kazis LE: Agreement between administrative data and patients’ self-reports of race/ethnicity. Am J Public Health. 2003, 93 (10): 1734-1739. 10.2105/AJPH.93.10.1734.View ArticlePubMedPubMed CentralGoogle Scholar
- Boehmer U, Kressin NR, Berlowitz DR, Christiansen CL, Kazis LE, Jones JA: Self-reported vs administrative race/ethnicity data and study results. Am J Public Health. 2002, 92 (9): 1471-1472. 10.2105/AJPH.92.9.1471.View ArticlePubMedPubMed CentralGoogle Scholar
- Freedland SJ, Kane CJ, Amling CL, Aronson WJ, Presti JC, Terris MK: Delay of radical prostatectomy and risk of biochemical progression in men with low risk prostate cancer. J Urol. 2006, 175 (4): 1298-1302. 10.1016/S0022-5347(05)00646-4. discussion 1302-1293View ArticlePubMedGoogle Scholar
- Vickers AJ, Roobol MJ, Lilja H: Screening for prostate cancer: early detection or overdetection?. Annu Rev Med. 2012, 63: 161-170. 10.1146/annurev-med-050710-134421.View ArticlePubMedGoogle Scholar
- Andrews SF, Horwitz EM, Feigenberg SJ, Eisenberg DF, Hanlon AL, Uzzo RG, Pollack A: Does a delay in external beam radiation therapy after tissue diagnosis affect outcome for men with prostate carcinoma?. Cancer. 2005, 104 (2): 299-304. 10.1002/cncr.21184.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6963/13/314/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.