Pharmaceutical care issues identified by pharmacists in patients with diabetes, hypertension or hyperlipidaemia in primary care settings
© Chua et al.; licensee BioMed Central Ltd. 2012
Received: 27 July 2012
Accepted: 31 October 2012
Published: 12 November 2012
The roles of pharmacists have evolved from product oriented, dispensing of medications to more patient-focused services such as the provision of pharmaceutical care. Such pharmacy service is also becoming more widely practised in Malaysia but is not well documented. Therefore, this study is warranted to fill this information gap by identifying the types of pharmaceutical care issues (PCIs) encountered by primary care patients with diabetes mellitus, hypertension or hyperlipidaemia in Malaysia.
This study was part of a large controlled trial that evaluated the outcomes of multiprofessional collaboration which involved medical general practitioners, pharmacists, dietitians and nurses in managing diabetes mellitus, hypertension and hyperlipidaemia in primary care settings. A total of 477 patients were recruited by 44 general practitioners in the Klang Valley. These patients were counselled by the various healthcare professionals and followed-up for 6 months.
Of the 477 participants, 53.7% had at least one PCI, with a total of 706 PCIs. These included drug-use problems (33.3%), insufficient awareness and knowledge about disease condition and medication (20.4%), adverse drug reactions (15.6%), therapeutic failure (13.9%), drug-choice problems (9.5%) and dosing problems (3.4%). Non-adherence to medications topped the list of drug-use problems, followed by incorrect administration of medications. More than half of the PCIs (52%) were classified as probably clinically insignificant, 38.9% with minimal clinical significance, 8.9% as definitely clinically significant and could cause patient harm while one issue (0.2%) was classified as life threatening. The main causes of PCIs were deterioration of disease state which led to failure of therapy, and also presentation of new symptoms or indications. Of the 338 PCIs where changes were recommended by the pharmacist, 87.3% were carried out as recommended.
This study demonstrates the importance of pharmacists working in collaboration with other healthcare providers especially the medical doctors in identifying and resolving pharmaceutical care issues to provide optimal care for patients with chronic diseases.
KeywordsPharmaceutical care Pharmacist Chronic disease Intervention Drug-related problem
The roles of pharmacists have evolved from product oriented, dispensing of medications to more patient-focused services such as the provision of pharmaceutical care, which includes the identification, prevention and resolution of drug-related problems (DRPs). The term “pharmaceutical care” was defined by Hepler and Strand . Basically, it is the responsible provision of drug therapy by the collaboration of a clinical pharmacist with the patient as well as other members of the healthcare team in designing, implementing and monitoring a therapeutic plan that will produce specific outcomes.
DRPs are defined as “problems in the pharmacotherapy of the individual patient that actually or potentially interfere with desired health outcomes” . Among the most common DRPs are: adverse drug reactions, drug choice problem, dosing problem, drug-use problem and interactions . Other terminology such as pharmaceutical care issues (PCIs) has also been used .
Studies have shown that the cost associated with DRPs far exceed the cost of medications. Ernst & Grizzle  found that the estimated cost of morbidity and mortality due to DRPs was more than USD177.4 billion yearly.
Wermeille and colleagues  reported PCIs resolved by community pharmacists in collaboration with medical general practitioners (GPs). Other studies reported a significant reduction in HbA1c in community-based patients with diabetes provided pharmaceutical care by a pharmacist [7–12]. A systematic review conducted by Royal and colleagues  showed that pharmacist-initiated medication review was effective in reducing hospital admission by 36%. However, most of the studies on pharmaceutical care were conducted in countries such as Australia, the United Kingdom and the United States [6, 7, 14–20]. Studies in South East Asia are scarce and therefore, this study is warranted to fill the information gap by identifying the types of PCIs encountered by primary care patients with diabetes mellitus, hypertension or hyperlipidaemia in Malaysia.
This study was part of a large controlled trial called the Cardiovascular Risk Factors Intervention Strategies (CORFIS) trial. The CORFIS trial was a community-based, multicentre trial which compared the impact of collaborative intervention by various healthcare professionals (GPs, pharmacists, dietitians and nurses) to usual standard care on patients with diabetes, hypertension or hyperlipidaemia. All the patients in the intervention group of the CORFIS trial were included in this part of the study. Patients in the control group were not included in this part of the study because under the usual healthcare practice in Malaysia, patients who seek treatment in GP clinics obtained their medications from the clinic itself and do not have to see a pharmacist. The study was approved by the Medical Research Ethics Committee of the Ministry of Health Malaysia.
Participants were recruited from 44 GP clinics in the Klang Valley, Malaysia from January to June 2008. The Klang Valley encompasses Kuala Lumpur and its vicinity which constitutes the main commercial and administrative centre in Malaysia. Inclusion criteria of patients were: participants aged 18 and above, with at least one of the following diseases: diabetes mellitus, hypertension or hyperlipidaemia, and currently managed with at least one medication. Exclusion criteria were those who did not provide written consent, were pregnant or breast-feeding, had history of unstable angina, heart failure, acute myocardial infarction, clinically significant valvular heart disease, stroke, coronary revascularization procedure, or who had serum creatinine of more than 150 mmol/L in the preceeding 6 months, or were not able to visit the clinics for monthly follow-up sessions. Written informed consent for participation in the study was obtained from all participants.
The primary outcome was the types of PCIs encountered by the participants, as identified by the pharmacists. The secondary outcomes were the causes and clinical significance of the PCIs, and outcome of the interventions made by the pharmacists.
All data collected were analysed using the Statistical Package for Social Sciences (SPSS Inc., Chicago, IL, USA), version 16. Descriptive statistics were obtained for all data. Sample means and standard deviations (SDs) were presented for continuous variables while frequencies and percentages were calculated for categorical variables. All outcome measures were classified by two pharmacists who were involved with the design and conduct of the study hence, were very familiar with the PCIs identified. However, to prevent bias, the clinical significance of the PCIs was classified independently by a clinician and another pharmacist who were not involved in the study. All classifications were based on “The PCNE Classification V 5.01”  except for the outcome of interventions and the clinical significance of the PCIs. Some additional categories of classification were added to cover the broad spectrum of PCIs encountered in this study as some could not be put under the categories specified by the PCNE.
Clinical significance of the PCIs was classified based on the four categories used by Stubbs et al. : Grade (1) probably clinically insignificant, (2) minimal clinical significance, (3) definitely clinically significant and could cause patient harm and (4) potentially life-threatening. These PCIs were initially classified independently by a clinician and a pharmacist. The results were tested for correlation using Kappa statistics, κ. The strength of agreement is as followed: κ < 0.20 is poor, 0.21–0.40 is fair, 0.41-0.60 is moderate, 0.61-0.80 is good and 0.81-1.00 is very good . A consensus on the final classification was derived with the assistance of another clinician and another pharmacist.
Demographics and clinical characteristics of participants recruited at baseline
Intervention (n = 477)
Age , mean years (SD)
Gender, frequency (%)
Ethnic Group, frequency (%)
Education, frequency (%)
Cardiovascular comorbidities, frequency (%)
DM + HPT
DM + HLP
HPT + HLP
DM + HPT + HLP
Smoking history, frequency (%)
Pharmaceutical Care Issues
Categories of PCIs according to PCNE V5.01 classification
Adverse drug reactions
Muscle ache and cramps
Drug choice problems
No clear indication for drug
No drug prescribed but clear indication
Drug not required
Dose too low or frequency not enough
Dose too high or frequency too often
Duration of treatment too short
Duration of treatment too long
Drug use problems
Drug not taken or administered at all
Non-adherence to medication
Worries about complications/ADRs
Monitoring for side effects
Non-adherence to medications was the most common drug-use problem (146 of 235 issues, 62.1%). Other drug-use problems involved participants administrating their medications at incorrect doses or frequencies or incorrect timing with respect to meals. For example, metformin and aspirin were taken before meals and sulphonylureas were taken at bedtime.
PCIs classified under “insufficient awareness or knowledge” included 47 issues pertaining to the misconception of participants concerning the use of medications and participants’ lack of knowledge and queries about their medications and also their disease states. Fifteen issues were related to participants’ undue worries about the side effects and complications related to their medications and another 82 issues of unclear complaints concerning some health problems which may be related to patients’ medications were also included in this category.
Adverse drug reactions (ADRs) included side effects of medications as reported by the participants. Examples of these side effects are as shown in Table 2. Hypoglycaemia was related to the use of antidiabetic agents. Gastrointestinal disturbances included gastritis due to non-steroidal anti-inflammatory drugs (NSAIDs) and diarrhoea associated with the use of metformin (6 cases each). Another 12 participants complained of dry cough attributed to the use of angiotensin-converting enzyme inhibitors while 10 participants complained of muscle aches and cramps after using statins. ADRs classified as “Others” included dermatological reactions such as eczema, rashes and itch; weight gain; frequent urination; hair loss; bradycardia; bleeding from the anus; blocked nose and flushing.
Therapy failure was assumed when participants’ blood pressure (BP), blood glucose levels or lipid levels were not at target levels despite being on pharmacological treatment. Whereas, drug choice problem in this study involved participants who had been seen by the GPs but still with high BP, high blood glucose or high cholesterol level and were not on any medications. Inappropriate duplication of therapeutic group or active ingredient involved two participants who were given both glimepiride and gliclazide, another participant was given gliclazide 80 mg (Diamicron®) and modified-release gliclazide 30 mg (Diamicron MR®) while another participant was given irbesartan (Approvel®) and a combination of irbesartan and hydrochlorothiazide (Co-Approvel®). In addition, one participant was on both loratadine and desloratadine. The only case of contraindication encountered in this study involved a woman planning to get pregnant but was prescribed a combination of irbesartan and hydrochlorothiazide (Co-Approvel®) .
Dosing problems included doses and frequencies of medications prescribed which were either too high or too low. Two cases with problems in the duration of treatment involved a participant given a statin for only a week and another who was still prescribed a statin even though his cholesterol level was only 2.9 mmol/L and his low-density lipoprotein (LDL) was 1.3 mmol/L.
Dispensing issues involved incorrect labeling of the dosage or frequency of antidiabetic drugs. There were two cases where the strength of enalapril was wrongly stated on the label. Another case involved atorvastatin (Storvas®) being labeled as simvastatin. In addition, a participant was prescribed irbesartan (Approvel®) but was dispensed irbesartan and hydrochlorothiazide (Co-Approvel®). Another participant was dispensed 40 mg of atorvastatin although was prescribed only 10 mg. This subclass of PCIs also included two cases of inappropriate storage of medication. Glyceryl trinitrate (GTN) was dispensed in a plastic envelope instead of its original bottle. Atovarstatin was kept in a plastic envelope and the colour of the tablets had changed. These PCIs were brought to the attention of the GPs or clinic staff concerned to prevent repetition of such issues.
Potential drug interactions included the use of enalapril with allopurinol which may increase the risk of leucopenia and hypersensitivity induced by allopurinol; fenofibrate and atorvastatin which may increase the risk of myopathy, and the use of atorvastatin with alcohol which may increase the risk of liver problems [23, 24].
The eight cases of lifestyle modifications included participants who were current smokers and were counselled on smoking cessation. There were several cases where participants asked about diet and exercise but these were referred to the dietitian and not considered as PCIs. Monitoring of side effects included alerting the doctors to monitor participants’ liver function for those on statins and blood glucose level in a patient suspected to have diabetes.
Classification of PCIs according to clinical significance
A Cohen’s Kappa statistic (k) of 0.729 (P = 0.036) was obtained which implied good agreement in classification between the two assessors. Of the 706 PCIs, 52% were classified as probably clinically insignificant, 38.9% with minimal clinical significance, 8.9% as definitely clinically significant and could cause patient harm while one issue (0.2%) where a participant reported bleeding from the anus attributed to the use of aspirin was classified as life threatening.
Causes of PCIs
Causes of PCIs (using The PCNE Classification V 5.01)
Frequency (%, n = 706)
1. Drug/Dose selection
Inappropriate drug selection
Inappropriate dosage selection
More cost-effective drug available
Pharmacokinetic problems, include ageing/deterioration in organ function and interactions
Synergistic/preventive drug required and not given
Deterioration/improvement of disease state
New symptom or indication revealed/presented
Manifest side effect, no other cause
2. Drug use process
Inappropriate timing of administration and/or dosing intervals
Drug underused/ under-administered
Drug overused/ over-administered
Patient unable to use drug/form as directed
Too many medications*
Inappropriate duration of use*
New drug prescribed*
Instructions for use/taking not known
Patient unaware of reason for drug treatment
Lack of communication between HCPs
Miscommunication between doctor and patient*
Patient forgets to use/take drug
Patient has concerns with drugs
Patient suspects side effects
Patient unwilling to carry financial cost
Patient unwilling to adapt life-style
Burden of therapy
Treatment not in line with health beliefs
Patient unaware of possible complications*
Patient unaware of drug name*
Out of medication*
Overseas or travelling*
Patient unaware of tablet strength*
Patient does not trust HCPs*
Patient on traditional medicine*
Patient on too many supplements*
Patient’s meal time is different*
Patient shared medications
Non-adherence to medications*
Prescribing error (only in case of slip of the pen)
Dispensing error (wrong drug or dose dispensed)
Patient anxious about glucose level*
Patient not sure of using glucose meter or other devices*
Wrong frequency of glucose monitoring*
Drug stored in unsuitable condition*
Patient not on medication in record*
No obvious cause
Outcome of pharmacist intervention
The most common intervention made by the pharmacists was the counselling of patients on their medications (38.8%), followed by the referral of patients to the prescribers (20.8%), educating patients concerning their disease states (12.0%), recommending a change in the dose or frequency of the medications or to add another medication (5.8%) and to monitor the patient’s condition (5.0%).
Outcome of interventions
Outcome of interventions
Frequency (% of subtotal)
Frequency (%, n = 702*)
Change made as per pharmacist recommendation
Change made not as per pharmacist recommendation
No change made, medication not dispensed
No change made
No change required
This study is probably the first large scale trial conducted in Malaysia which involved collaboration between various healthcare professionals in the management of diabetes, hypertension or hyperlipidaemia at primary care level. More than half of the participants encountered at least one PCI, with a total of 706 PCIs identified.
Drug-use problems (especially non-adherence to medication), ADRs, therapeutic failure and drug-choice problems constituted the main PCIs encountered by participants in this study, followed by insufficient awareness or knowledge of participants. Wermeille and colleagues  reported similar results. The high number of PCIs encountered by the participants indicates the importance of pharmacists working in collaboration with other healthcare providers to identify and resolve such problems. These include educating participants on the purpose and side effects of medications to clear their doubts and misconception, which would lead to better understanding and hence better medication adherence .
Participants were taking their medications incorrectly in terms of dose, frequency and timing in relation to meals (8.2% of the PCIs). This again indicates that the provision of pharmaceutical care is essential to identify and resolve such problems in order to achieve optimal clinical outcomes and also to reduce side effects such as gastrointestinal disturbances.
Therapy failure constitutes 13.9% of the PCIs. The usual recommendations for such issues were to increase the dose or frequency of existing medication or to add another medication. Patients were also advised to monitor their BP or blood glucose level where appropriate. Constant monitoring of BP, blood glucose levels and lipid profile is crucial to ensure that these clinical conditions are within target levels in order to prevent complications and to reduce morbidity and mortality [26, 27]. In addition, lifestyle modification was also often recommended.
The 11 dispensing issues identified in this study are not reflective of the incidence of dispensing problems encountered as this study was not designed specifically to determine dispensing errors, hence no direct observation of the dispensing process was carried out. Examples of dispensing errors noted in this study only served to alert the healthcare professionals, especially those involved in dispensing of medications at the primary care clinics, that such errors may occur and measures should be taken to minimize such risk.
Drug choice and dosing problems are usually detected via double-checking by an independent person. Pharmacists can act as a safety net to prevent or minimize any potential medication errors. These included a case of contraindication which involved a woman planning to get pregnant but was prescribed an angiotensin-receptor blocker which carries a potential risk of teratogenesis if the woman did get pregnant . Again, the number of prescribing discrepancies that were identified is not indicative of the incidence of such problems as prescriptions issued to participants of this study were not screened individually.
Most of the PCIs were considered to be of no direct potential clinical significance (52%), especially non-adherence to medications and some minor side effects, but they could cause inconvenience and prolongation of the issues may lead to complications and increased cost of treatment. Incorrect timing of drug administration were considered to have minimal clinical significance, except for aspirin which has a higher risk of causing gastrointestinal complications and thus was classified as definitely clinically significant.
The main causes of PCIs were deterioration or improvement of disease state which led to therapy failure, and also presentation of new symptoms or indication. This indicates the role of pharmacists in monitoring patients with chronic diseases. The manifestation of side effects such as cough, gastrointestinal problems and symptoms of hypoglycaemia as well as patients’ concerns with drugs and undue worries about side effects were also common causes of PCIs. In these aspects, counselling of patients by the pharmacist is important to resolve some of the preventable side effects and also to assure and increase patients’ confidence concerning their medications. Consequently, educating and counselling patients on their medications and disease states were the main interventions made by the pharmacists (50.8%) in this study. Often, patients were referred to the prescribers (20.8%) especially if adjustment to patients’ prescribed medication regimens were deemed necessary.
In this study, most of the recommendations made by the pharmacists (87.3%) were carried out accordingly. This indicates the effectiveness of the pharmacist interventions in resolving PCIs as well as the doctor and patients’ confidence in following the recommendations made by pharmacists. Other studies have also shown that pharmacist interventions produced positive outcomes [13, 28, 29] and well accepted by the doctors and patients .
This study has several strengths. The CORFIS trial was performed in private primary care settings in Malaysia, highlighting the feasibility of collaboration between pharmacists, GPs, dietitians, nurses and patients in diabetes, hypertension and hyperlipidaemia risk management. The study had an adequate sample size and follow-up duration. It is probably the first study in Malaysia, which involved the collaboration of various healthcare professionals in managing primary care patients with chronic diseases.
There are also several limitations in this study. The process of detecting and resolving PCIs is very time consuming since there is a time-lag between identification and subsequently communicating the PCI to the caregiver involved, especially in a community setting. Potential bias in the detection and resolving of PCIs may exist since this depended heavily on the experience of the pharmacist performing the medication review. The classification of the PCIs, causes and outcomes were performed by two pharmacists based on the information recorded by the service pharmacist. Although care has been taken to be as accurate as possible in the classification, some ambiguities could not be ruled out. In addition, the classification of the clinical significance of the PCIs identified was not re-tested.
This study identifies the types of PCIs encountered by patients with diabetes, hypertension or hyperlipidaemia. It also demonstrates the importance of pharmacists working in collaboration with other healthcare providers especially the GPs, in resolving these PCIs to provide optimal care for patients with chronic diseases.
Pharmaceutical care issue
Adverse drug reaction
Medical general practitioner
Pharmaceutical Care Network Europe
Cardiovascular Risk Factors Intervention Strategies.
This study was registered with ClinicalTrials.org (identifier no NCT00490672) and funded by an unrestricted research grant from the National Institute of Health, Ministry of Health Malaysia, MRG-CRC-2007-00.
We are grateful to Dato Sri Dr Hasan bin Abdul Rahman, the Director General of Health, Malaysia for permission to publish this article and to the Clinical Research Centre (CRC), Ministry of Health, Malaysia for supporting this study.
Our greatest appreciation to the CORFIS team especially to Dr Lim Teck Onn and Dato' Dr. Zaki Morad Mohd Zaher, the principal investigators, and to Mr Wilson Low Hong Hoo, Ms Dan Siew Peng, Ms Kimberly Wong, Ms Nor Fasihah Yahaya and Ms M Vatsala Nair Manoha for coordinating the CORFIS trial.
We like to acknowledge other members of the Pharmacist Research Group for helping to plan and coordinate this study. These include Ms Farida Islahudin, Ms Jennifer Tan See Hui, Ms Najwa Mohd Nasir, Ms Norliah Ardee, Ms Ong Jo Yi, Ms Oon Hong Ying, Ms Rosiah Harun and Ms Zawiyah Mat Johor. We also like to thank Dr Lynda Ng, Dr Sharon Teoh and Ms Lee Hui Chin for helping to classify the PCIs.
We also like to express our upmost gratitude to all the service pharmacists for their effort and time spent in providing pharmaceutical care to the intervention participants and in recording all the required data. Thank you very much to all of you.
We are thankful to all the other health care providers such as the general practitioners, nurses and dietitians for a successful collaborative effort in managing the patients and for their kind assistance and cooperation throughout the study. We hope this collaborative spirit will continue for the benefits of the patients.
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