Effectiveness of a multidisciplinary care program on recovery and return to work of patients after gynaecological surgery; design of a randomized controlled trial
© Vonk Noordegraaf et al; licensee BioMed Central Ltd. 2012
Received: 23 December 2011
Accepted: 1 February 2012
Published: 1 February 2012
Return to work after gynaecological surgery takes much longer than expected, irrespective of the level of invasiveness. In order to empower patients in recovery and return to work, a multidisciplinary care program consisting of an e-health intervention and integrated care management including participatory workplace intervention was developed.
We designed a randomized controlled trial to assess the effect of the multidisciplinary care program on full sustainable return to work in patients after gynaecological surgery, compared to usual clinical care. Two hundred twelve women (18-65 years old) undergoing hysterectomy and/or laparoscopic adnexal surgery on benign indication in one of the 7 participating (university) hospitals in the Netherlands are expected to take part in this study at baseline. The primary outcome measure is sick leave duration until full sustainable return to work and is measured by a monthly calendar of sickness absence during 26 weeks after surgery. Secondary outcome measures are the effect of the care program on general recovery, quality of life, pain intensity and complications, and are assessed using questionnaires at baseline, 2, 6, 12 and 26 weeks after surgery.
The discrepancy between expected physical recovery and actual return to work after gynaecological surgery contributes to the relevance of this study. There is strong evidence that long periods of sick leave can result in work disability, poorer general health and increased risk of mental health problems. We expect that this multidisciplinary care program will improve peri-operative care, contribute to a faster return to work of patients after gynaecological surgery and, as a consequence, will reduce societal costs considerably.
Netherlands Trial Register (NTR): NTR2087
KeywordsMultidisciplinary care program e-health intervention integrated care management participatory workplace intervention gynaecological surgery hysterectomy laparoscopic adnexal surgery return to work work disability
Health care problem
Research on duration of full recovery and Return To Work (RTW) after (laparoscopic) gynaecological surgery has shown large discrepancy between expected physical recovery and actual return to work [1–3]. This may be explained by the fact that duration of recovery and RTW is mainly influenced by the expectations of the patient and employer, rather than by physical factors or the type of surgery [4–6]. However, in most cases there is hardly attention for RTW expectations . In general, gynaecologists do discuss the needs and risks concerning the surgical intervention and expected duration of hospitalization with their patient, but structural convalescence recommendations regarding the resumption of (work) activities are mostly not provided [1, 8]. In addition, after discharge the patient usually has only one post-operative check-up six weeks after surgery, which is focused on examination of the physical condition. Other medical care is fragmented and given only on demand, as a result of which patients often do not know whom to contact for support in case of postoperative complaints. Due to Dutch legislation, patients with paid work who do not RTW within six weeks after surgery, are generally consulted by their Occupational Physician (OP). However, as a result of the lack of recognised guidelines on the resumption of (work) activities and poor communication between the gynaecologists, General Practitioners (GPs) and OPs, often indistinct and conflicting recommendations are given and additionally most physicians do not differentiate according to the type of surgery [9–11]. These factors contribute to uncertainties and irrational beliefs of patients, which may result in delayed recovery, prolonged sick leave and reduced quality of life [12, 13].
The Dutch Health Council stated, in line with the International Classification of Functioning, disability and health (ICF) model that there is a strong need for multidisciplinary recommendations for resumption of postoperative work activities [14, 15]. However, little is known about patients' needs, (illness) beliefs and preferences regarding postoperative care and resumption of work activities . Therefore, we previously explored patients' peri-operative needs using focus group discussions with gynaecological patients and performing a systematic review of the literature . Detailed multidisciplinary convalescence recommendations were developed in collaboration with the medical board of gynaecologists, OPs and GPs through a modified Delphi consensus method with experts . To mirror the target group, the focus group discussions and Delphi study were geared towards patients who underwent a hysterectomy (abdominal, vaginal, laparoscopic) or laparoscopic adnexal surgery on benign indication. These types of surgeries were chosen, because they are the most frequently performed (major) gynaecological surgical procedures with a considerable postoperative effect on recovery and RTW and yearly count for more than 17.500 procedures in the Netherlands .
Multidisciplinary care program
Based on the results of the modified Delphi study, the outcomes of the focus group discussions, the literature review and considering both the ICF model as well as the Attitude, Social influence and self-Efficacy (ASE) model in which important determinants of recovery and RTW are described [20, 21], a multidisciplinary care program for gynaecological patients undergoing surgery was developed. The care program aims at the different aspects of curative treatment as well as at personal and external factors. In addition, it tries to encourage patients in resuming activities and participation in the society. The program consists of an interactive e-health intervention, integrated care management and a participatory workplace intervention. The e-health intervention was developed through an intervention mapping protocol  and specifically aims at the empowerment of gynaecological patients and their environment during the pre- and postoperative period (from around four weeks before until eight weeks after surgery) . This includes encouragement of patients in resuming daily and work activities. If the patient is still on sick leave 10 weeks after surgery, the integrated care management and participatory workplace intervention will be offered. This part of the intervention is based on a previous study with patients with chronic low back pain , and was adapted to our target group for this study.
The main objective of this study is to evaluate the effectiveness of the multidisciplinary care program (e-health intervention, integrated care management & participatory workplace intervention) compared to usual care regarding full sustainable RTW for patients after hysterectomy or laparoscopic adnexal surgery on benign indication. Secondary objectives of the study are 1) to study the effect of the multidisciplinary care program on general recovery, quality of life, pain intensity and complications; 2) to investigate how the program is evaluated by the patients, their health care providers and their employers and 3) to validate the multidisciplinary convalescence recommendations developed in het Delphi study .
The CONsolidated Standards Of Reporting Trials (CONSORT) statement was followed to describe the design of this study. This checklist is used worldwide to improve the reporting of Randomized Controlled Trials (RCT) [24–26].
Organization of the study
The seven participating hospitals in this study will be six general (teaching) hospitals and one University hospital, all localized in or nearby Amsterdam: 1)The Amstelland Hospital; 2)The Flevo Hospital; 3) The Kennemer Gasthuis; 4) The Onze Lieve Vrouwe Gasthuis; 5) The Sint Lucas Andreas Hospital; 6) The Spaarne Hospital and 7) The VU University Medical Center.
Recruitment of patients
Participants for the study will be recruited from the waiting lists of participating hospitals. Patients scheduled for a hysterectomy or laparoscopic adnexal surgery because of benign disorders will receive an invitation letter on behalf of their gynaecologist, together with an information package consisting of: 1) patient information letter about the study, 2) Informed Consent (IC), 3) reply card to send to the researchers when not interested in participation in the study and finally, depending on the requirements of the particular hospital, 4) a leaflet about participating in scientific research in general.
When the researchers do not receive a reply card of the patient within two weeks after the delivery of the information package, they will make contact to evaluate whether she is interested in participation in the study. Phone numbers and addresses of these patients will be send to the researchers by the participating hospitals weekly. Patients willing to participate and meeting the inclusion criteria will be asked to return the signed IC and will receive the baseline questionnaire about four weeks before surgery. Subsequently, when both are filled out and the surgery is scheduled within four weeks, the patient will be randomized for the intervention or usual care group.
Eligible patients for this study are women aged between 18-65 years, employed for at least 8 hours per week (paid or unpaid) and scheduled in one of the participating hospitals for a laparoscopic adnexal surgery and/or hysterectomy due to benign disorders. Exclusion criteria for this study are: 1) (suspicion of) malignancy; 2) (ectopic) pregnancy; 3) deep infiltrating endometriosis; 4) concomitant surgical procedures or major health problems/psychiatric disorders affecting recovery or daily activities; 5) being sick listed for more than 4 weeks, or when the surgery is to cure the reason of the absence of work, sick listed for more than 2 months; 6) working temporarily for an employment agency without detachment; 8) dealing with a lawsuit against their employer; 9) not able to understand or complete the questionnaires written in the Dutch language and 10) no access to internet.
To prevent unequal randomization between hospitals, patients will be pre-stratified by hospital and type of surgery (laparoscopic adnexal surgery, total laparoscopic-/laparoscopic assisted-, vaginal- and abdominal hysterectomy). A computer-generated block randomization will be performed on individual level. The blocks consist of four characters to ensure roughly equal group sizes with each stratum and are randomly varying in sequence. Randomization will be executed by an (independent) research assistant, after the patient has completed baseline measurements and IC.
Control group; placebo e-health intervention and usual peri-operative care
In the Netherlands, there is a considerable variation in given peri-operative care and convalescence recommendations for gynaecological patients. The number of consultations and also the available time for counselling differs per hospital. After discharge, in general the patient receives one appointment for a post-operative check-up in an outpatients' department for about six weeks after surgery. Other medical care by gynaecologists and GPs is given only on demand. Patients with paid work who do not RTW within six weeks after surgery, are generally consulted by their OPs due to Dutch legislation.
In addition to given usual care, patients in the control group of this RCT will get access to a placebo e-health intervention. This website has five unique pages and provides the patient with a patient leaflet and telephone numbers of the participating hospitals. The patient leaflet is derived from The Dutch Society of Obstetrics and Gynaecology (NVOG) website and forms the basis of almost all leaflets provided in Dutch hospitals for hysterectomy or laparoscopic adnexal surgery on benign indication [27, 28].
Intervention group; multidisciplinary peri-operative care program
Patients in the intervention group, receive normal usual peri-operative care with the adjustment that the care providers supply standardized detailed convalescence recommendations to the patients . In addition, this group will get access to an e-health intervention and, when they have not returned to work completely within ten weeks after surgery, supplementary care of a clinical occupational physician and (if relevant) a workplace intervention by an Occupational Therapist (OT) will be offered. This stepped care approach of additional care will be described in detail below.
Step 1: all patients get access to an e-health intervention from four weeks before surgery
Structure of the e-health intervention 
1. Compose a work reintegration plan
■ Tool to compose a detailed reintegration plan with adaptations for work if necessary.
➢ Patient, Employer, OP
2. Resume normal activities
■ Tool to compose detailed advice about when normal (private) activities can be carried out again
➢ Patient, family
3. Evaluate complications
■ Estimate severity and consequences of a complication
➢ Patient, gynaecologist
4. Recovery Monitor
■ Monitoring recovery and offering assistance when relevant
5. Satisfaction with recommendations
■ Evaluation and explanation of convalescence recommendations
6. Satisfaction with the recovery process
■ Evaluation of satisfaction with recovery and reintegration process. Provision of advice regarding which care provider(s) to approach to receive appropriate help, when relevant.
7. Invite Employer
■ Invite employer for (anonymous) section of the website which includes video (see below) and recommendations
➢ Patient, Employer
■ Illustrate common pitfalls during the peri-operative and reintegration period
➢ Patient, employer, gynaecologist
9. Recommendations for employee
■ Advice for a successful reintegration
10. Recommendations for employer
■ Advice for appropriate involvement regarding employee during the peri-operative and reintegration period
11. Frequently asked questions
■ Extensive list of answers and pictures to most frequently asked questions
■ Explanation of most frequently used medical terms
■ Ability to interact in public or through private messages with other patients
14. Links to other websites
■ Relevant websites concerning the peri-operative and reintegration period
■ Well-defined convalescence recommendations after hysterectomy and laparoscopic adnexal surgery
Step 2: if sick leave exceeds ten weeks, additional integrated care management including workplace intervention will be offered
This part of the intervention will only be offered to the patient when she is not fully returned to work ten weeks after surgery and consists of two main protocols; 1) Integrated care protocol and 2) Workplace intervention protocol and is based on a previous study of patients with chronic low back pain .
Integrated care protocol
Integrated care and workplace intervention protocol
Weeks after surgery
Integrated care protocol
Carried out by the clinical occupational physician
Workplace intervention protocol
Carried out by the Occupational Therapist (OT)
a. History taking and physical examination to identify:
• adequacy of illness behaviour
• presence of psychosocial problems
• inadequate treatment
• limitations at work influencing RTW (e.g. physical heavy work, organizational obstacles).
b. Contact patients' other care providers (if relevant).
c. Diagnosis of the medical situation or problem(s)
d. Propose a treatment and rehabilitation plan (with a RTW prognosis).
e. Discuss the treatment and rehabilitation plan with the patient and her occupational physician. If both agree
Contact OT to start the workplace intervention protocol (if relevant)
Call in the assistance of patients' employer and relevant care provider(s)
Discuss the advisory plan (developed by the OT) with the OT
a. Observation, inventory and ranking of patient's tasks and obstacles for RTW at the patients' workplace.
b. Inventory and ranking patients' tasks and obstacles for RTW by the patients' employer.
c. Patient, patients' employer and the OT brainstorm and discuss as many potential solutions as possible, for the problems identified in step a en b.
d. Solutions are sorted and prioritized based on implementation time, costs and contribution to the problem(s).
The OT reports (in consultation with the clinical occupational physician) an advisory plan specifying what has to be done, how, when and by whom. This report is sent to the patient, the patient's employer, OP and the clinical occupational physician.
Optional worksite visit to give additional instructions or training to the patient on working in the modified setting.
a. Evaluate the diagnosis, effect of the treatment and progress
b. If necessary, adjust the date of RTW
Evaluation between the patient, patients' employer and the OT (by telephone) with regard to the effects of the workplace adaptations. Further improvements are sought for when solutions have prove not to be totally effective.
Final report is sent to the patient, the patient's employer, OP and the clinical occupational physician.
Third and final consultation:
a. Evaluate the diagnosis, effect of the treatment and progress
b. If necessary, adjust the date of RTW
c. Hand the employee over to her own OP
Workplace intervention protocol
The workplace intervention procedure starts when the clinical occupational physician refers the patient to the OT, an expert to provide work (place) adaptations. The clinical occupational physician will define the conditions (working hours, duties, etc) under which the patient may return to work, which should be adopted by the OT and communicated effectively to the patient and the employer. The workplace intervention is based on methods used in 'participatory ergonomics' [30, 31] and presumes strong commitment of both the patient and employer. This intervention has been developed originally for patients with chronic low back pain [30, 32] and has shown to be (cost) effective in this population [33, 34]. For this study, the protocol is adapted to post-operative gynaecological patients, regarding time-schedule and involved care providers. The consecutive steps of the workplace intervention protocol are described in table 2. The main aim of this intervention is patients' full RTW in their own or equal work. To achieve this aim, the OT will try to reach consensus between patient and her employer regarding feasible solutions for the obstacles for RTW. The solutions will be judged on short-term implementation possibilities, affordability and problem solving capability. After consensus has been reached, patient, patient's employer and OT will agree on an implementation plan, which will be evaluated during following weeks.
Overview of outcome measures & variables in this study
Outcome measures & variables
2 wks after surgery
6 wks after surgery
12 wks after surgery
26 wks after surgery
1) Return to worka
2) Total duration of sick leavea
3) First RTWa
• Recovery specific QoL (RI-10)
• Performed activities
• Performed activities measured by e-health interventionb, c
at least 2, 4, 7, 14, 21, 28, 42, 56, 84 days after surgery
5) Functional and general health status (SF36, EuroQoL)
6) Pain intensity (Von Korff)
7) Empowerment (GSES)
8) Health care usage (TicP)
9) Occurrence of complications during the post-operative period
• Complications measured by e-health interventionb, c
at least 7, 14, 21, 28, 42, 56, 84, 126 and 182 days after surgery
10) Socio-demographic variables
11) Type of surgery
12) Complications during surgery
13) Work-related factors (DMQ, JCQ, additional questions)
14) Pain perception and fear avoidance belief (Tampa scale)
15) Sick leave duration in the past three months
16) Expectations, intention and motivation for return to work
17) Patients attitudes, opinions and compliance regarding the convalescence recommendations and tools of the e-health interventiona
18) Physicians' and employers' attitude en opinion regarding the multidisciplinary care programb
19) Satisfaction with care program and care providers (e.g. PSOHQ)
20) Use of the e-health interventionb
21) Suggestions for improvement of the e-health intervention
22) Provided convalescence recommendations by the care providers according to the patients
Primary Outcome measures
The primary outcome measure in this study is sick leave duration until full RTW, defined as: duration of sick leave in calendar days from the day of surgery until full RTW in own or other work with equal earnings, for at least four weeks without (partial or full) recurrence . This means that recurrences of sickness absence within four weeks after first day of full RTW, will be considered as belonging to the preceding period of sick leave, on condition that this is due to the consequences of the surgery. RTW will be measured by a monthly calendar of sickness absence.
Secondary Outcome measures
The total duration of sick leave (due to the consequences of the surgery) during the 26 weeks follow-up period; measured by a monthly calendar of sickness absence.
First RTW; measured by a monthly calendar of sickness absence.
Recovery; measured by a validated Recovery Specific Quality Of Life questionnaire RS-QOL(RI10) , an extended list of (graded) activities based on the detailed convalescence recommendations given to the patients of the intervention group  and a recovery monitor which is a tool of the e-health intervention of the intervention group.
Pain intensity; measured using Von Korff questionnaire .
Empowerment; assessed by the Dutch adaptation of the General Self-Efficacy Scale .
The occurrence of complications in the post-operative period; assessed by questions based on the complication registration form of The Dutch Society of Obstetrics and Gynaecology (NVOG) . Patients in the intervention group do also answer these questions more frequently through a tool of the e-health intervention, in order to register possible side effects of the intervention and to determine and inform them when symptoms require additional consultation of care providers or adaptation of convalescence recommendations.
Socio-demographic data; measured by the standard Dutch version of the EuroQol  and specific additional socio-demographic questions.
Type of surgery.
Complications during surgery; assessed by questions based on the complication registration form of The Dutch Society of Obstetrics and Gynaecology (NVOG) .
Pain perception and fear avoidance belief; assessed by the Tampa scale .
Sick leave duration in the past 3 months.
Expectations, intention and motivation of the employee about return to work after surgery .
Outcomes regarding process evaluation
Patient's attitudes, opinions and compliance regarding the convalescence recommendations and the tools of the e-health program.
Physicians' and employers' attitude en opinion regarding the multidisciplinary care program.
Satisfaction with care program and care providers; measured with the short version of the Patient Satisfaction with Occupational Health Services Questionnaire (PSOHQ)  and specific additional questions related to health care and care providers.
The use of the e-health intervention during the follow-up period (e.g. total login time, amount of mouse-clicks, use of particular tools, et cetera).
Suggestions for improvement of the e-health intervention.
Provided convalescence recommendations by the care providers according to the patients.
Power calculation was performed on the primary outcome (all kind of surgeries together). To achieve a power (1-β) of 80%, with a significance level (α) of 5% and considering a HR of 1.5 in favour of the intervention group, approximately 191 patients will be needed. Anticipating a 10% drop out rate, in total a sample size of at least 212 patients will be aimed for. To recruit this number of patients, the study will anticipate on a ten-month inclusion period.
Patients will be blinded for the allocated treatment. Treatment allocation (randomization) will take place by computer-generated block randomization after completion of baseline questionnaire and IC. After randomization, all patients will receive access to the e-health intervention. However, after logging into the website with their personal login credentials, the kind of information provided by the e-health intervention will depend on the group the patient is randomized for.
During recruitment, the patients will be told that in case they do not RTW within 10 weeks after surgery, they might be approached for supplementary care depending on the care program they are randomized for. Nevertheless, explanation will only be given about the comparison of two different types of information supply and peri-operative guidance and not about the content of peri-operative guidance according to the 'intervention' or 'control' group.
Due to the different treatments in both groups, therapists and researchers cannot be blinded for the allocated treatment of the patient.
All statistical analyses will be performed at patient level, according the Intention-To-Treat (IIT) principle. To assess whether protocol deviations have caused bias, the results of the ITT analyses will be compared to per protocol analyses in which the patients who were not treated according to the intervention protocol, will be excluded. To examine the success of the randomization, baseline characteristics of the patients in both groups will be compared using descriptive statistics. If necessary, analyses will be adjusted for prognostic dissimilarities.
A Kaplan Meier analysis (including the log rank test) will be used to describe the association between the group allocation and the duration of sick leave until the first period of full sustainable RTW. The Cox proportional hazard model will be used to estimate hazard ratios for RTW and the corresponding 95% confidence interval.
Details of ethics approval
The study design, protocols, procedures and IC were approved by the Medical Ethics Committees of all participating hospitals: the VU University Medical Center (date 22-10-2009, number 2009/218), the Amstelland Hospital (12-02-2010, number 10-54), the Flevo Hospital (date 10-12-2009, number FZ09/35), the Kennemer Gasthuis (03-03-2010, number 2010.02), the Onze Lieve Vrouwe Gasthuis (date 21-01-2010, number 09.067), the Sint Lucas Andreas Hospital (03-11-2009, number 09/114) and the Spaarne Hospital (20-01-2010, number 561.09).
This paper describes a RCT to study the effect of a multidisciplinary care program on recovery and full sustainable return to work of women who underwent a hysterectomy and/or a laparoscopic adnexal surgery on benign indication. Since work participation contributes to well-being and recovery of illness, the program particularly pays attention to stimulate patients in gradually resuming normal activities including RTW [13, 55]. During the first step of the multidisciplinary care program, all patients get access to the e-health intervention, which primarily aims to empower patients' behavioural determinants and supports adequate beliefs regarding recovery and RTW in patients with an uncomplicated postoperative course . These are prognostic factors for recovery and RTW and account for the personal determinants in the ICF model. Secondary, the e-health intervention provides tools through which environment (e.g. family, employer), clinical condition, participation and resuming of activities may be influenced. The second step of the care program is only offered when sick leave exceeds ten weeks and thus to patients with a complicated recovery and RTW. The goal of this step is to prevent work disability. It contains additional integrated care management by a multidisciplinary team consisting of a clinical occupational physician, gynaecologist and OT and includes a workplace intervention. This step mainly focuses on reducing barriers for RTW by improving communication between different care providers, OP, employer and patient.
Strengths and limitations
The implementation of this study in six general (teaching) and a University hospital is a good reflection of the Dutch health care situation. In addition, the selection bias of patients will be restricted through the proactive way of inviting all patients on the waiting lists to participate in the RCT. Therefore, selection will take place only based on clearly defined in- and exclusion criteria. A third strength is the blinding of the patients, which will minimize the Hawthorne and placebo effect . Furthermore, the primary outcome measure in this study is full sustainable RTW, which takes into account recurrences of sick leave within four weeks after RTW and therefore reduces underestimation of work-loss days . Another strength regarding the outcome measures is the evaluation of patients' health and recovery through clinical, participatory and activity outcome measures. By doing so, the influence of the care program on the different aspects of human functioning and state of health according to the ICF model, will be evaluated . All patients receive their own research code according to which all data were stored in the databases. This ensures blinded analysis of the data by the researchers. Finally, this is the first study to extensively evaluate consensus-based guidelines with detailed convalescence recommendations regarding return to normal and work activities after gynaecological surgery [18, 58]. The guidelines represent a consensus opinion of expert-based knowledge between gynaecologists, GPs and OPs and this study will show whether these recommendations reflect realistic recovery times for gynaecological patients and will bring about a quicker recovery without an increase in complications compared with usual care.
The main limitation of this study is that contamination between the intervention and control group cannot completely be prevented, because the randomization will be performed on patient level. With regard to the health care providers, it is impossible to blind them for the intervention allocation, because the allocation determines the kind of convalescence recommendations that should be given to the patient. Therefore, it is important for them to follow and distinguish consequently the protocol belonging to the intervention versus the control group. Contamination may occur when care providers use acquired insights received through the convalescence recommendations for the intervention group to adapt their usual care and convalescence recommendations given to the control group. To minimize this effect, we will only proactively work on the familiarity of the protocols among the health care providers and not on the detailed contents of the convalescence recommendations for the patients in the intervention group. The patients' gynaecologists will only receive a summary of the guideline by means of their patients' record, in order to pass it on to the patient at discharge from the hospital. GPs and OPs will only receive the guideline when the patient hands over her tailored convalescence recommendations or work reintegration plan to them. A learning curve of the health care providers to flawlessly execute the protocol in the intervention group may be expected. This implementation curve may result in less effect of the intervention during the beginning of the study, which should receive attention during the analysis of the results. To accelerate the implementation of the protocol, pocket maps with the description of the intervention will be distributed, teaching meetings with the health care providers about the protocol will be organized and the protocol will be added to the medical file of the patient. Although therapists and researchers cannot be blinded for the allocated treatment of the patient, they will not be involved in measuring the outcomes, since all outcome measures are self-reported and the questionnaires will be sent by email or post to the patients. Therefore, it is unlikely that the way patients complete the questionnaires, will be influenced by the researcher and care providers. Moreover, the therapists of the multidisciplinary team (RTW-coordinator, OT, and other care providers), will not be involved in the assessment of the outcomes. With concern to contamination between patients of the intervention and control group, a chance meeting cannot be excluded. According to the protocol, patients from different groups should not be placed in the same hospital room, but it cannot be prevented that patients will meet outside the room. Another limitation of this study is the fact that the integrated care management and the workplace intervention will be carried out by one clinical occupational physician and OT, which might affect the execution of the intervention. However, both will work according to a detailed standardized protocol in order to minimize their personal influence on performance of the intervention as much as possible. Compliance to e-health interventions is sometimes low. We tried to minimize the risk of low compliance as much as possible by spending extra effort and time on involving the stakeholders (end-users) in the development of this intervention and adapting it to their specific needs by use of the intervention mapping protocol . Finally, although the participating hospitals reflect the proportion of (non) university hospitals in the Netherlands, they are all located in the urban agglomeration in the Western part of the Netherlands, which might be of influence on the educational level of the patient population. Because research has shown that both living in the city as well as higher educational level are associated with more frequent use of the internet for health or illness matters, it should be determined whether the educational level and internet use of the participating patients reflects that of the general Dutch population, before the results of this study can be interpreted as representative of all gynaecological patients in the Netherlands .
Yearly more than 17.500 women receive a hysterectomy or laparoscopic adnexal surgery on benign indication in the Netherlands . These large numbers of surgeries have a great impact on absenteeism since it is expected that approximately 67 percent of women aged between 25 and 65 years have paid work . Therefore, if this multidisciplinary care program reduces medical consultation by providing patients with tailored, detailed and unambiguous convalescence recommendations, improves communication between care providers and stimulates patients in a faster sustainable RTW, this relatively cheap intervention may potentially decrease the sick leave costs of gynaecological patients in the Netherlands.
If the multidisciplinary guidelines evaluated in this study will bring about a quicker recovery without an increase in complications, they will be implemented broadly in the Netherlands in collaboration with the participating medical board of gynaecologists, OPs and GPs. After implementation, the expectation is that the guidelines will result in more unambiguous detailed convalescence recommendations given by gynaecologists, GPs and OPs, through which patients will be better informed about when it is medically safe to resume daily and work activities after gynaecological surgery and give them the possibility to arrange (workplace) adaptations if necessary. Furthermore, the unambiguous recommendations will likely enhance the compliance to advice given by medical specialists and stimulate the patient to resume activities with increasing gradations of strain, which will presumably bring about a quicker recovery without an increase of complications [61, 62]. Therefore, the guidelines may potentially prevent work disability, increase quality of life (QoL) and increase patient satisfaction with care.
International Classification of Functioning
Randomized Controlled Trial
Return To work
Acknowledgements and funding
This study was carried out with funding of ZonMw (project number 150020037), an organization for health research and development in the Netherlands.
- Dirksz AA, Bruinvels DJ, de Vet HCW, Brolmann HA: Werkhervatting na gynaecologische ingrepen; Pilot Study. 1-1-2008
- Johansen P, Al-Khafagi SK, Thostesen LM, Lauszus FF, Rasmussen KL: Analysis of need for sick leave after hysterectomy. Ugeskr Laeger. 2008, 170: 1465-1468.PubMed
- Rasmussen KL, Hansen V, Madzak F, Ljungstrom B, Lauszus FF: Feeling of illness after hysterectomy. Women's own assessment Sygdomsfolelse efter hysterektomi. Kvindernes egen vurdering. Ugeskr Laeger. 2001, 163: 7040-7042.PubMed
- Clayton M, Verow P: A retrospective study of return to work following surgery. Occup Med (Lond). 2007, 57: 525-531. 10.1093/occmed/kqm082.View Article
- Jones KR, Burney RE, Peterson M, Christy B: Return to work after inguinal hernia repair. Surgery. 2001, 129: 128-135. 10.1067/msy.2001.111696.View ArticlePubMed
- Callesen T, Klarskov B, Bech K, Kehlet H: Short convalescence after inguinal herniorrhaphy with standardised recommendations: duration and reasons for delayed return to work. Eur J Surg. 1999, 165: 236-241. 10.1080/110241599750007108.View ArticlePubMed
- Clayton M, Verow P: Advice given to patients about return to work and driving following surgery. Occup Med (Lond). 2007, 57: 488-491. 10.1093/occmed/kqm063.View Article
- Ottesen M, Moller C, Kehlet H, Ottesen B: Substantial variability in postoperative treatment, and convalescence recommendations following vaginal repair. A nationwide questionnaire study. Acta Obstet Gynecol Scand. 2001, 80: 1062-1068.PubMed
- van Amstel RJ, Anema JR, Jettinghoff K, Verbeek JH, Nauta AP, van Putten DJ: Limited change in the quality of the social medical guidance and in the satisfaction of sick-listed patients, after collaborative projects between general practitioners and occupational physicians. Ned Tijdschr Geneeskd. 2005, 149: 2407-2412.PubMed
- Moller C, Ottesen M, Kehlet H, Ottesen BS: Convalescence recommendations after hysterectomy. A study of opinions among Danish physicians. Ugeskr Laeger. 2001, 163: 7043-7047.PubMed
- van Well AM, van Ijsseldijk AL, Bonjer HJ, Vrijland WW, Brouwer KJ, de Boer K: Onnodig thuis; ziekteverzuim na liesbreukoperatie. Medisch Contact. 2002, 18: 696-699.
- Bisgaard T, Klarskov B, Rosenberg J, Kehlet H: Factors determining convalescence after uncomplicated laparoscopic cholecystectomy. Arch Surg. 2001, 136: 917-921. 10.1001/archsurg.136.8.917.View ArticlePubMed
- Waddell G, Burton AK: Is work good for your health and well-being?. The Stationary Office. 2006
- WHO: International Classification of Functioning, Disability and Health. 2001
- Gezondheidsraad: Beoordelen, behandelen begeleiden. Medisch handelen bij ziekteverzuim en arbeidsongeschiktheid Den Haag. 2005
- Young AE, Wasiak R, Roessler RT, McPherson KM, Anema JR, van Poppel MN: Return-to-work outcomes following work disability: stakeholder motivations, interests and concerns. J Occup Rehabil. 2005, 15: 543-556. 10.1007/s10926-005-8033-0.View ArticlePubMed
- Vonk Noordegraaf A, Huirne JA, Pittens CA, Van Mechelen W, Broerse JE, Brolmann HA, Anema JR: E-health program to empower patients in returning to normal activities and work after gynaecological surgery: Intervention mapping as a useful method for development. Journal of Medical Internet Research, provisional accepted. 2012
- Vonk Noordegraaf A, Huirne JA, Brolmann HA, Van Mechelen W, Anema JR: Multidisciplinary convalescence recommendations after gynaecological surgery: a modified Delphi method among experts. BJOG. 2011, 118: 1557-1567. 10.1111/j.1471-0528.2011.03091.x.View ArticlePubMed
- Stichting Informatie Gezondheidszorg. Verrichtingen; 2009, Landelijke Medische Registratie LMR (Prismant)
- de Vries H, Dijkstra M, Kuhlman P: Self-efficacy: The third factor besides attitude and subjective norm as a predictor of behavioural intentions. Health Educ Res. 1988, 273-282.
- de Vries H: Determinanten van gedrag. Gezondheidsvoorlichting en gedragsverandering [Health education and behavioral change]. 1993, 109-132.
- Bartholomew LK, Parcel GS, Kok G, Gottlieb NH: Planning health promotion programs. An Intervention Mapping Approach. 2nd edition. San Francisco, CA: Jossey-Bass; 2006
- Lambeek LC, van Mechelen W, Knol DL, Loisel P, Anema JR: Randomised controlled trial of integrated care to reduce disability from chronic low back pain in working and private life. BMJ. 2010, 340: c1035-10.1136/bmj.c1035.PubMed CentralView ArticlePubMed
- Begg C, Cho M, Eastwood S, Horton R, Moher D, Olkin I, et al: Improving the quality of reporting of randomized controlled trials. The CONSORT statement. JAMA. 1996, 276: 637-639. 10.1001/jama.1996.03540080059030.View ArticlePubMed
- Moher D, Hopewell S, Schulz KF, Montori V, Gotzsche PC, Devereaux PJ, et al: CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. BMJ. 2010, 340: c869-10.1136/bmj.c869.PubMed CentralView ArticlePubMed
- Schulz KF, Altman DG, Moher D: CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. BMC Med. 2010, 8: 18-10.1186/1741-7015-8-18.PubMed CentralView ArticlePubMed
- Kleiverda G: De laparoscopische operatie. 1998, Nederlandse Vereniging voor Obstetrie en Gynaecologie, [http://www.nvog.nl//Sites/Files/0000000411_laparoscopische_operatie.pdf]
- Overmars K, Kleiverda G: Baarmoederverwijdering bij goedaardige aandoeningen. 2005, Nederlandse Vereniging voor Obstetrie en Gynaecologie, [http://www.nvog.nl/Sites/Files/0000000075_Baarmoederverwijdering_bij_goedaardige_aandoeningen.pdf]
- Anema JR, Buijs PC, van Amstel RJ, van Putten DJ: Leidraad voor huisarts en bedrijfsarts bij de sociaal-medische begeleiding van arbeidsverzuim. 1090125/r2003530. 1-3-2002. TNO
- Anema JR, Steenstra IA, Urlings IJM, Bongers PM, de Vroome EMM, Van Mechelen W: Participatory ergonomics as a return-to-work intervention: a future challenge?. Am J Ind Med. 2003, 44: 273-281. 10.1002/ajim.10259.View ArticlePubMed
- de Jong AM, Vink P: Participatory ergonomics applied in installation work. Appl Ergon. 2002, 33: 439-448. 10.1016/S0003-6870(02)00033-9.View ArticlePubMed
- Lambeek LC, Anema JR, Van Royen BJ, Buijs PC, Wuisman PI, van Tulder MW, et al: Multidisciplinary outpatient care program for patients with chronic low back pain: design of a randomized controlled trial and cost-effectiveness study [ISRCTN28478651]. BMC Public Health. 2007, 7: 254-10.1186/1471-2458-7-254.PubMed CentralView ArticlePubMed
- Anema JR, Steenstra IA, Bongers PM, de Vet HCW, Knol DL, Loisel P, et al: Multidisciplinary rehabilitation for subacute low back pain: graded activity or workplace intervention or both? A randomized controlled trial. Spine (Phila Pa 1976). 2007, 32: 291-298. 10.1097/01.brs.0000253604.90039.ad.View Article
- Loisel P, Abenhaim L, Durand P, Esdaile JM, Suissa S, Gosselin L, et al: A population-based, randomized clinical trial on back pain management. Spine. 1997, 22: 2911-2918. 10.1097/00007632-199712150-00014.View ArticlePubMed
- NETQ Internet Surveys 6.7. Software for creating and assessment of Internet Surveys. Utrecht, The Netherlands, NetQuestionnaires Nederland BV; 2011
- Bhandari A, Wagner T: Self-reported utilization of health care services: improving measurement and accuracy. Med Care Res Rev. 2006, 63: 217-235. 10.1177/1077558705285298.View ArticlePubMed
- Short ME, Goetzel RZ, Pei X, Tabrizi MJ, Ozminkowski RJ, Gibson TB, et al: How accurate are self-reports? Analysis of self-reported health care utilization and absence when compared with administrative data. J Occup Environ Med. 2009, 51: 786-796. 10.1097/JOM.0b013e3181a86671.PubMed CentralView ArticlePubMed
- Severens JL, Mulder J, Laheij RJ, Verbeek AL: Precision and accuracy in measuring absence from work as a basis for calculating productivity costs in The Netherlands. Soc Sci Med. 2000, 51: 243-249. 10.1016/S0277-9536(99)00452-9.View ArticlePubMed
- de Vet HCW, Heymans MW, Dunn KM, Pope DP, van der Beek AJ, Macfarlane GJ, et al: Episodes of low back pain: a proposal for uniform definitions to be used in research. Spine (Phila Pa 1976). 2002, 27: 2409-2416. 10.1097/00007632-200211010-00016.View Article
- Kluivers KB, Hendriks JCM, Mol BWJ, Bongers MY, Vierhout ME, Brolmann HAM, et al: Clinimetric properties of 3 instruments measuring postoperative recovery in a gynecologic surgical population. Surgery. 2008, 144: 12-21. 10.1016/j.surg.2008.03.027.View ArticlePubMed
- Dolan P: Modeling valuations for EuroQol health states. Med Care. 1997, 35: 1095-1108. 10.1097/00005650-199711000-00002.View ArticlePubMed
- Aaronson NK, Muller M, Cohen PD, Essink-Bot ML, Fekkes M, Sanderman R, et al: Translation, validation, and norming of the Dutch language version of the SF-36 Health Survey in community and chronic disease populations. J Clin Epidemiol. 1998, 51: 1055-1068. 10.1016/S0895-4356(98)00097-3.View ArticlePubMed
- Ware JEJ, Sherbourne CD: The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992, 30: 473-483. 10.1097/00005650-199206000-00002.View ArticlePubMed
- Von Korff M, Ormel J, Keefe FJ, Dworkin SF: Grading the severity of chronic pain. Pain. 1992, 50: 133-149. 10.1016/0304-3959(92)90154-4.View ArticlePubMed
- Teeuw B, Schwarzer R, Jerusalem M: Dutch Adaptation of the General Self-Efficacy Scale. 1994, Berlin, Germany, [http://userpage.fu-berlin.de/~gesund/publicat/ehps_cd/health/dutch.htm]
- Hakkart-van Roijen : Manual trimbos/iMTA questionnaire for costs associated with psychiatric illness (TiC-P). 2002, Trimbos
- Oostenbrink JB, Bouwmans CAM, Koopmans MA, Rutten FFH: Manual for cost studies, methods and standard cost-prices for economis evaluation in health care [In Dutch: Handleiding voor kostenonderzoek, methoden en standaard kostprijzen voor economische evaluaties]. 2004, Board of health care insurance
- The Dutch Society of Obstetrics and Gynaecology (NVOG): Complicatieformulier Gynaecologie en Obstetrie. 25-9-2006. NVOG, [http://www.nvog.nl/upload/files/ccrformulier_250906.pdf]
- Hildebrandt VH, Bongers PM, van Dijk FJ, Kemper HC, Dul J: Dutch Musculoskeletal Questionnaire: description and basic qualities. Ergonomics. 2001, 44: 1038-1055. 10.1080/00140130110087437.View ArticlePubMed
- Karasek R, Brisson C, Kawakami N, Houtman I, Bongers P, Amick B: The Job Content Questionnaire (JCQ): an instrument for internationally comparative assessments of psychosocial job characteristics. J Occup Health Psychol. 1998, 3: 322-355.View ArticlePubMed
- Vlaeyen JW, Kole-Snijders AM, Boeren RG, van Eek H: Fear of movement/(re)injury in chronic low back pain and its relation to behavioral performance. Pain. 1995, 62: 363-372. 10.1016/0304-3959(94)00279-N.View ArticlePubMed
- Damoiseaux V, van der Molen HT, Kok GJ: Gezondheidsvoorlichting en gedragsverandering. Assen: Van Gorcum. 1993
- Steckler A, Linnan L: Process evaluation for public health interventions and research. 2002, San Francisco: Jossey-Bass
- Verbeek JH, de Boer AG, van der Weide WE, Piirainen H, Anema JR, van Amstel RJ, et al: Patient satisfaction with occupational health physicians, development of a questionnaire. Occup Environ Med. 2005, 62: 119-123. 10.1136/oem.2004.016303.PubMed CentralView ArticlePubMed
- Commissie Psychische Arbeidsongeschiktheid: Leidraad Aanpak verzuim om psychische redenen. 2001
- Berthelot J, Le Goff B, Maugars Y: The Hawthorne effect: Stronger than the placebo effect?. Joint Bone Spine. 2011
- Baldwin ML, Butler RJ: Upper extremity disorders in the workplace: costs and outcomes beyond the first return to work. J Occup Rehabil. 2006, 16: 303-323.View ArticlePubMed
- Minig L, Trimble EL, Sarsotti C, Sebastiani MM, Spong CY: Building the evidence base for postoperative and postpartum advice. Obstet Gynecol. 2009, 114: 892-900. 10.1097/AOG.0b013e3181b6f50d.View ArticlePubMed
- Santana S, Lausen B, Bujnowska-Fedak M, Chronaki CE, Prokosch HU, Wynn R: Informed citizen and empowered citizen in health: results from an European survey. BMC Fam Pract. 2011, 12: 20-10.1186/1471-2296-12-20.PubMed CentralView ArticlePubMed
- Centraal Bureau voor de Statistiek: Statline databank. 2009
- Ottesen M, Sorensen M, Kehlet H, Ottesen B: Short convalescence after vaginal prolapse surgery. Acta Obstet Gynecol Scand. 2003, 82: 359-366. 10.1034/j.1600-0412.2003.00147.x.View ArticlePubMed
- Bay-Nielsen M, Thomsen H, Andersen FH, Bendix JH, Sorensen OK, Skovgaard N, et al: Convalescence after inguinal herniorrhaphy. Br J Surg. 2004, 91: 362-367. 10.1002/bjs.4437.View ArticlePubMed
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6963/12/29/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.