An economic evaluation of adaptive e-learning devices to promote weight loss via dietary change for people with obesity
© Miners et al.; licensee BioMed Central Ltd. 2012
Received: 30 March 2011
Accepted: 11 June 2012
Published: 7 July 2012
The prevalence of obesity is over 25% in many developed countries. Obesity is strongly associated with an increased risk of fatal and chronic conditions such as cardiovascular disease and type 2 diabetes. Therefore it has become a major public health concern for many economies. E-learning devices are a relatively novel approach to promoting dietary change. The new generation of devices are ‘adaptive’ and use interactive electronic media to facilitate teaching and learning. E-Learning has grown out of recent developments in information and communication technology, such as the Internet, interactive computer programmes, interactive television and mobile phones. The aim of this study is to assess the cost-effectiveness of e-learning devices as a method of promoting weight loss via dietary change.
An economic evaluation was performed using decision modelling techniques. Outcomes were expressed in terms of Quality-Adjusted Life-Years (QALYs) and costs were estimated from a health services perspective. All parameter estimates were derived from the literature. A systematic review was undertaken to derive the estimate of relative treatment effect.
The base case results from the e-Learning Economic Evaluation Model (e-LEEM) suggested that the incremental cost-effectiveness ratio was approximately £102,000 per Quality-Adjusted Life-Year (QALY) compared to conventional care. This finding was robust to most alternative assumptions, except a much lower fixed cost of providing e-learning devices. Expected value of perfect information (EVPI) analysis showed that while the individual level EVPI was arguably negligible, the population level value was between £37 M and £170 M at a willingness to pay between £20,000 to £30,000 per additional QALY.
The current economic evidence base suggests that e-learning devices for managing the weight of obese individuals are unlikely to be cost-effective unless their fixed costs are much lower than estimated or future devices prove to be much more effective.
KeywordsEconomic evaluation e-learning cost-utility analysis obesity and weight management.
According to recent Organisation for Economic Co-operation and Development (OCED) data, the prevalence of obesity has increased to almost 25% in countries such as England, Canada, Ireland and Australia and to over 30% in Mexico and the US . Obesity is associated with a higher risk of many diseases, including cardiovascular disease and type 2 diabetes [2–5]. It is also associated with significant costs to the health care- and other sectors. Unsurprisingly therefore, designing and delivering effective weight management interventions has become a priority in many countries and a focus for many public health programmes [5, 6].
Interventions to change dietary behaviour are an important method of tackling obesity [7–9]. Specifically, interventions designed to modify or replace diets high in saturated fats and sodium with those containing more fruit, vegetables and lower saturated fats. Indeed the WHO reports that the consumption of up to 600 g per day of fruit and vegetables could reduce the total worldwide burden of disease by 1.8%, and reduce the burden of ischaemic heart disease and ischaemic stroke by 31% and 19% respectively .
A new and evolving area in the promotion of dietary behavioural change is ‘e-Learning’, the use of interactive electronic media to facilitate teaching and learning on a range of issues including health. E-Learning devices (e-LDs) have grown out of recent developments in information and communication technology, such as the Internet, interactive computer programmes, interactive television, and mobile phones [11–15]. So-called ‘second and third generation’ e-Learning interventions use ‘adaptive’ interactive technology delivered on computers and portable devices, such as mobile phones to produce iterative, interactive and more immediate feedback . Moreover, they are rapidly becoming more accessible to the general population (e.g., an estimated 70% of the population in the UK has access to the internet and this percentage is likely to continue to grow ). The high level of accessibility, combined with emerging advances in computer processing power, data transmission and data storage, makes interactive e-LDs a potentially powerful and cost-effective medium for improving dietary behaviour and ultimately health [18–20]. However, while the general conclusion from three systematic reviews is that they show some promise in terms of dietary behaviour change [16, 21, 22], and a fourth suggests some encouragement in terms of weight loss , a number of important uncertainties remain. For example, the most recent review included studies published up to 2008 , they were restrictive in terms of patient entry criteria and, importantly, none assessed cost-effectiveness. The latter point is the focus of this study.
Decision problem and model basics
An economic decision model was built, referred to as the e-Learning Economic Evaluation Model (e-LEEM), to assess the cost-effective of the e-LDs. The model consists of a cost-utility analysis (CUA), with health outcomes expressed as quality-adjusted life-years (QALYs). Costs were assessed from a UK health services perspective, and expressed in 2009 prices. In all scenarios, the model was run until all patients died, implying a lifetime horizon for the analysis. All future costs and QALYs were discounted at 3.5% per annum.
Defining how an e-LD is used, and therefore its associated costs and outcomes, is difficult because they are idiosyncratic in terms of design, platform base, not all are commercially available and they and their use are often poorly described in the clinical trials. Thus, for the purpose of the economic evaluation a single hypothetical/generic package has been defined broadly reflecting the design and cost of an internet-based intervention evaluated in McConnon et al.  as it was a well described contemporary UK-based randomised controlled trial.
There are a number of possible comparator interventions for e-LDs, indeed weight management interventions are rarely used in isolation as results from the systematic review suggest . For this reason, and to be practical, a generic ‘conventional care’ arm was specified as the comparator intervention, implying an intervention that could contain a number of interventions such as generic dietary information and/or exercise but excluding interventions based on e-LDs or pharmacological treatment. The latter was included as a third treatment option in a sensitivity analysis in an attempt to put the results into a broader context. Note however, that the estimate of relative clinical effect was not based on formal indirect or mixed treatment comparisons.
A number of different modelling approaches were considered. The decision was made to use a discrete event simulation (DES) so that the likelihood of future clinical events and associated costs could be directly linked to individuals’ current health. Simulations were based on 1,000 outer (second order or probabilistic) simulations and 1,000 inner (first-order or micro) simulations. EVPI calculations were also undertaken based on a further 1,000 third-order simulations. The model was built in TreeAge Pro 2009 .
The decision problem
Starting characteristics for the base case analyses
Estimating time to events and natural history
The time to death was calculated using a life-table approach, as outlined by Barton et al. [27, 28]. In addition to this, 33%  of patients who developed cardiovascular disease (CVD) were assumed to die immediately once the event had occurred. All deaths from T2D were considered to be attributable to cardiac problems, thus they were not independently modelled. These approaches were used in the base case to avoid the possibility of double counting occurrences of death, thus it is arguably conservative. The QRISK2  algorithm was used to predict the risk of CVD. Two T2D risk equations were identified [31, 32]. While an arbitrary decision was made to use the Stern equation, the Lindström model was used in a sensitivity analysis.
While receiving treatment with either an e-LD or CC, the baseline annual bodyweight was assumed to change in line with results from a recently reported UK-based RCT [kg ~ N −1.9, 0.63] . Following treatment cessation, the natural history of BMI change was modelled using evidence cited in the 2005 NICE Obesity Guideline . Specifically Fine et al.,  state that the mean increase in weight over 4 years is 1 kg per year. The Guideline also states that this finding is consistent with the findings of Heitmann et al.  who performed a retrospective semi-longitudinal study to determine the pattern of weight changes over 11 years in a Danish population that became overweight in adulthood. Thus, all patients were assumed to put on an average of 1 kg per year independently of initial BMI levels.
Weight gain was converted into an increased BMI by assuming men were on average 1.75 ms tall whereas women were 1.62 ms tall . This is equivalent to a 0.33 and a 0.38 unit increase in BMI respectively, per 1 kg increase in weight [BMI = weight (kg)/height2 (m)] . This meant, for example, that it would take an average of 0.31 years (0.1/0.33) for a man’s BMI to increase by 0.1 kg/m2.
High attrition rates are a defining feature of weight loss/preventing weight gain interventions. Therefore the probability that individuals stopped treatment before 12 months, for reasons other than developing disease or death, was included. The Turnin 2001 RCT was used to estimate the base case probability of drop out, although this value was altered in a sensitivity analysis. The results showed that 179/557 participants were lost to follow-up over the 12 month period. Differences in attrition rates between the e-LD and CC treatment options were judged to be negligible and were not included in the model .
Estimating relative intervention effect
The cost-effectiveness of orlistat was also estimated in a single sensitivity analysis. Orlistat’s mean annual effect was estimated to be a loss of 3.46 kg, as reported by a review of three RCTs .
Costs were broadly divided into two types: those associated with specific events, and those relating to the initial 12 months of treatment (Table 1).
All costs were inflated to 2009 prices using the Hospital and Community Health Services Index . The costs of CVD were taken from Warren et al.,  and were reported as one-off costs for fatal, non-fatal events and an annual cost for survivors. No other costs associated specifically with CVD were included. The annual cost of diagnosed T2D was taken from Ara . The cost included 2 general practitioner visits per year, a specialist nurse visit, drug treatment for high blood pressure, statin therapy and treatment with metformin. The annual costs of CC and those associated with e-learning devices were taken from a UK-based RCT of web-based support package . The costs for both interventions included resources such as drug costs and health care visits and slimming clubs. The main difference between the two was that the internet-based support package included an additional fixed cost per patient of £854 per annum for the actual web-based support (meaning this cost was applied per patient irrespective of how long their treatment lasted in the base case). The yearly cost of orlistat treatment was assumed to be £415 (based on 120 mg treatment 3 times per day, at a unit price per pill of £0.38 [£32.27/84]), plus the cost of 5 GP visits (£35 per visit).
Description of costs
CVD fatal event
Gamma (9, 0.00295)
CVD non-fatal event
Gamma (9, 0.002469)
Annual cost of non-fatal CVD event
Gamma (9, 0.010309)
Annual cost of T2D
Gamma (9, 0.0125)
Annual cost attributable to orlistat
Annual cost of e-leaning device
£140 (SE £234)
Gamma (0.3549, 0.002535)
Fixed cost of e-learning device
Annual cost of conventional care
£226 (SE £329)
Gamma (0.479, 0.002088)
Base case results (see Table 4
for patient starting characteristics
Relationship between independent variables and EQ-5D utility scores, Macran et al.
BMI group (kg/m2)
Age group (years)
No. of LSIs*
Sensitivity analysis on scenario A patient characteristics
Doubling the time to a 0.1 BMI increase after treatment stops
£0 initial cost for e-learning devices
Lindstrom T2D risk equation
Starting age of 30 years
Starting age of 60 years
Using estimate of relative treatment effect from Turnin (N ~ −0.6, 0.71)
Doubling all T2D related costs
Doubling all CVD related costs
Doubling the cost of CC
0% discount rate for health benefits
Halving the attrition rate for both treatments
Treatment for 24 months
When orlistat was included as a comparator, it dominated e-LD. Against CC, orlistat cost almost £6,000 per additional QALY.
Expected value of perfect information (EVPI) analysis
A single expected value of information analysis for parameters (EVPPI) was undertaken on the relative treatment effect (weighted mean difference) associated with two treatment options. The results suggest that at a willingness to pay of £20,000 to £30,000 per additional QALY, the maximum value of conducting a further RCT was between £37 M and £170 M. However, these figures reduced to between £8 M and £36 M if the time horizon was reduced to 2 years
The aim of this study was to assess the cost-effectiveness of e-learning devices (e-LDs) compared with conventional care (CC) in people with obesity. An economic evaluation based on discrete event simulation techniques was used to synthesise data from the published literature together with results from a systematic review and meta-analysis of RCT evidence on the impact of treatment on BMI.
The model results suggest that under most circumstances, e-LDs are unlikely to be cost-effective at any reasonable willingness-to-pay threshold. Mainly because of the fixed costs of installing the devices coupled with a negligible impact on BMI. Only when the fixed cost of the e-LD was removed, or substantially lowered, did e-learning devices appear to be cost-effective.
The fixed costs associated with the e-LDs were difficult to assess. Largely because most of the published clinical evaluations did not report resource use/cost data, they are heterogeneous in nature and it was unclear whether any were commercially available (and therefore had an associated user fee). For these reasons, the fixed cost of the e-LDs, was taken directly from the trial by McConnon - an internet-based intervention. The associated costs comprised of the development and running costs of the website over the 12 month study period. An economic evaluation was performed alongside the RCT, and it too concluded that the e-LD was unlikely to be cost-effective largely because of the fixed cost. However, it is unclear whether all e-LDs have an associated fixed cost. Second, assuming they do, fixed costs are likely to decline as the number of users increases meaning they could be substantially lower than the mean value assumed in this analysis. Third, even if the fixed cost was zero, it is unclear whether commercial programme developers would charge a fee for using the programme, how much it would be and how frequently it would be charged.
The choice of comparator programme(s) is an important design decision for any economic evaluation. Here the choice was ‘conventional care’ as delivered by health care professionals, as the control arms in the systematic review tended to use a mix of interventions. For example, most of the trials that focussed on dietary change were not particularly explicit as to what advice was given (eg. choice of diet) or who provided it (eg. a physician or nurse). This is important because it is possible that different approaches may be more or less cost-effective compared with each other, and (implicitly) averaging them as is the case here, could be misleading from an incremental perspective. Of equal importance, CC, however delivered, is not the only method of reducing weight. For example, it is possible to promote exercise, to use drug treatments such as orlistat or to use combinations of these approaches. Although the analysis containing orlistat was only crude in so much that it was not based on formal indirect treatment comparisons, it does illustrate the point that even if e-LDs were considered cost-effective compared with CC, they might not be compared with other treatments.
A number of economic evaluations of web-based interventions to promote weight loss have previously been published [24, 45–47]. McConnon et al.  concluded that it cost about £40,000 per additional QALY if an internet programme replaced usual care, while the two other studies reported ICERs nearer US$5,000 to $7,000 per life-year gained. While these results are different to ours, there are a number of possible explanations. First, our study focused purely on e-learning devices. The other studies were not so restrictive in terms of the intervention specifics. Indeed the interventions evaluated by Krukowski  and Hersey  included an element of interaction with other patients, individual/group coaching sessions and telephone support, they were not e-learning devices. Second, our estimate of intervention effect was based on the results from a systematic review of 43 RCTs whereas the studies by McConnon and Krukowski were based on the results from single trials. Third, the study by Krukowski assumed in the base case that weight loss could not be regained, an assumption we consider to be unrealistic. Lastly, our study assessed the cost-effectiveness in people who were already considered to be obese. This is was an explicit criterion in the studies by McConnon and Hersey, but not in the evaluation by Krukowski. Indeed, the latter was said to have been performed in individuals who were highly educated, but few other details are provided. Therefore, while we have concluded that in our opinion e-LDs to promote dietary change and weight loss are unlikely to be cost-effective in obese populations, this conclusion should not necessarily be generalised to all web-based weight management interventions or to all population groups
There are undoubtedly a number of other limitations with the evidence used in the model. First, the QRISK2 risk equation is designed to assess the probability of developing primary CVD-events. Thus, the model takes does not take into account the possibility that individuals who survive one CVD event are more likely to experience another. However, it is unlikely that this would have a major bearing on the results given the negligible treatment effects.
The CVD and T2D risk equations take into account risk factors such as systolic blood pressure and cholesterol levels in addition to BMI. While the trials rarely reported changes in these risk factors, a more sophisticated modelling approach could take into account their likely correlations.
Potentially counter intuitive results were produced in a number of scenarios. For example, when the costs of T2D and CVD were increased, the ICER associated with e-learning also increased. This is because people treated with e-learning devices live longer on average with these conditions, even though they are less likely to develop them in the first instance. The net result is an increase in the incremental cost and the associated ICER. Such seemingly counter intuitive results were also reported in the NICE Obesity Guideline, along with a similar explanation .
The EVPI analysis suggested that the value of further research was arguably large, even with a 2 year horizon; e-based technologies are likely to have relatively short life-cycles. This is because despite the evidence of a relatively small clinical effect on BMI, the e-LDs are relatively cheap and the number of obese people is high compared with many other conditions
The e-LEEM model was built to assess the cost-effectiveness of e-learning devices compared to CC for people with obesity, as methods of promoting healthier eating and weight loss. The model contains a number of assumptions and necessarily draws on evidence from a number of different sources. The results suggest that e-LDs are unlikely to be cost-effective unless they have much lower fixed costs than estimated for this analysis or future designs prove to be much more effective. Despite this, the value of further RCT-based research is high, although researchers are strongly encouraged to provide fuller descriptions of the evaluated technologies.
AM built the economic model and drafted most sections of the report, JH, FL, EM, SM and PE designed and undertook the underpinning systematic review. EM also provided clinical expertise and knowledge about the use of e-learning devices. All authors contributed to the final write up.
National Institute for Health Research, Health Technology Assessment Programme
- OECD Health Data: 2011, [http://stats.oecd.org/Index.aspx?DataSetCode=HEALTH_LVNG].
- Rolls BJ, Shide DJ: The influence of dietary fat on food intake and body weight. Nutr Rev. 1992, 50: 283-290.View ArticlePubMedGoogle Scholar
- Willet WC: Diet and health: What should we eat?. Science. 1994, 264: 532-538. 10.1126/science.8160011.View ArticleGoogle Scholar
- World Health Organization: 2003, In. Geneva: WHO:Diet, Nutrition, and the Prvention of Chronic Diseases
- Department of Health: Choosing health: making healthier choices easier. 2004, London: Choosing health: making healthier choices easierGoogle Scholar
- Department of Health: 2005, In. London: Choosing a Better Diet: a food and health action plan, 1-52.
- Balcombe NR, Ferry PG: Saweirs WM. Nutritional Status and Well Being. Is There a Relationship Between Body Mass Index and the Well-Being of Older People? Current Medical Research and Opinion. 2001, 17 (1): 1-7.Google Scholar
- World Health Organization: Reducing Risks. 2002, In. Geneva: Promoting Healthy LifeGoogle Scholar
- World Cancer Research Fund: American Institute of Cancer Research, Food, nutrition and physical activity and the prevention of Cancer. 2007, In. Washington DC: Global perspectiveGoogle Scholar
- Lock K, Pomerleau J, Causer L, Altman DR, McKee M: The global burden of disease attributable to low consumption of fruit and vegetables: implications for the global strategy on diet. Bull of the World Health Organization. 2005, 83 (2): 100-108.Google Scholar
- Brug J, Oenema A, Kroeze W, Raat H: The internet and nutrition education: challenges and opportunities. Eur J Clin Nutr. 2005, 59 (Suppl 1): S130-S139.View ArticlePubMedGoogle Scholar
- Martin Gould SM, Anderson J: Using interactive media nutrition education to reach low-income persons: an effectiveness evaluation. J Nutr Educ. 2000, 32: 204-213. 10.1016/S0022-3182(00)70558-9.View ArticleGoogle Scholar
- Tate DE, Jackvony EH, Wing RR: Effects of internet behavioral conuselling on weight loss in adults at risk for type 2 diabetes: a randomized trial. JAMA. 2003, 289: 1833-1836. 10.1001/jama.289.14.1833.View ArticlePubMedGoogle Scholar
- Oenema A, Brug J, Lechner L: Web-based tailorednutrition education: results of a randomized controlled trial. Health Educ Res. 2001, 16: 647-660. 10.1093/her/16.6.647.View ArticlePubMedGoogle Scholar
- Eng TR: The eHealth landscape: a terrain map of emerging information and communication technologies in health and health care. 2001, Princeton NJ: Robert Wood Johnson FoundationGoogle Scholar
- Neville LM, O'Hara B, Milat AJ: Computer-tailored dietary behaviour change interventions: a systematic review. Health Educ Res. 2009, 24 (4): 699-720. 10.1093/her/cyp006.View ArticlePubMedPubMed CentralGoogle Scholar
- Office for National Statistics: Statistical Bulletin: Internet Access. 2009, In. United Kingdom: Households and IndividualsGoogle Scholar
- Kanuga M, Rosenfeld WD: Adolescent sexuality and the internet: the good, the bad, and the URL. J Pediatr Adolesc Gynecol. 2004, 17 (2): 117-124. 10.1016/j.jpag.2004.01.015.View ArticlePubMedGoogle Scholar
- Patrick K, Robinson TN, Alemi F, Eng TR: the Science Panel on Interactive Communication and Health: Policy issues relevant to evaluation of interactive health communication applications. Am J Preventive Med. 1999, 16: 35-42.View ArticleGoogle Scholar
- Williams P, Nicholas D, Huntington P: McClean F. Surfing for health: user evaluation of a health information web site. Part 1, Literature review. Health Information, Library Journal. 2002, 19: 98-108.Google Scholar
- Kroeze W, Werkman A, Brug J: A systematic review of randomized trials on the effectiveness of computer-tailored education on physical activity and dietary behaviors. Ann Behav Med. 2006, 31 (3): 205-223. 10.1207/s15324796abm3103_2.View ArticlePubMedGoogle Scholar
- Norman GJ, Zabinski MF, Adams MA, Rosenberg DE, Yaroch AL, Atienza AA: A review of eHealth interventions for physical activity and dietary behavior change. Am J Preventive Med. 2007, 33 (4): 336-345. 10.1016/j.amepre.2007.05.007.View ArticleGoogle Scholar
- Neve M, Morgan PJ, Jones PR, Collins CE: Effectiveness of web-based interventions in achieving weight loss and weight loss maintenance in overweight and obese adults: a systematic review with meta-analysis. Obes Rev. 2010, 11 (4): 306-321. 10.1111/j.1467-789X.2009.00646.x.View ArticlePubMedGoogle Scholar
- McConnon A, Kirk SFL, Cockroft JE, Harvey EL, Greenwood DC, Thomas JD, Ransley JK, Bojke L: The Internet for weight control in an obese sample. 2007, BMC Health Services Research: Results of a randomised controlled trial, 7-206.Google Scholar
- Edwards P, Landon J, Lock K, Free C, Ferguson E, Michie S, Miners A, Harris JLF: Adaptive e-learning to improve dietary behaviour: a systematic review and cost-effectiveness analysis. Health Technol Assessment. 2011, 15: 37.Google Scholar
- TreeAge Software I: TreeAge Pro 2009 user's manual. 2009, Williamstown, MA: TreeAge Software IncGoogle Scholar
- Barton P, Jobanputra P, Wilson J, Bryan S, Burls A: The use of modelling to evaluate new drugs for patients with a chronic condition. 2004, the case of antibodies against tumour necrosis factor in rheumatoid arthritis, In: Health Technology AssessmentGoogle Scholar
- Life tables: [http://www.statistics.gov.uk/StatBase/Product.asp?vlnk=14459].
- Volimink JA, Newton JN, Hicks NR, Sleight P, Fowler GH, Neil HAW: Coranary events and case fatality rates in an English population: results of the Oxford myocardial infarction incidence study. Heart. 1998, 80: 40-44.View ArticleGoogle Scholar
- Hippisley-Cox J, Coupland C, Vinogradova Y, Robson J, Minhas R, Sheikh A, Brindle P: Predicting cardiovascular risk in England and Wales: prospective derivation and validation of QRISK2. BMJ. 2008, 336 (7659): 1475-1482. 10.1136/bmj.39609.449676.25.View ArticlePubMedPubMed CentralGoogle Scholar
- Stern MP, Williams MS, Haffner SM: Identification of Persons at High Risk for Type 2 Diabetes Mellitus: Do We Need the Oral Glucose Tolerance Test?. Ann Intern Med. 2002, 136: 575-581.View ArticlePubMedGoogle Scholar
- Lindstrom J, Tuomilehto J: The diabetes risk score. 2003, Diabetes Care, 26.Google Scholar
- NICE: CG43. 2006, Obesity: the prevention, identification, assessment and management of overweight and obesity in adults and childrenGoogle Scholar
- Fine J, Colditz G, Coakeley E, Moselay G, Manson J, Willet W: A Prospective Study of Weight Change and Health Related Quality of Life in Women. JAMA. 1999, 282: 2136-2142. 10.1001/jama.282.22.2136.View ArticlePubMedGoogle Scholar
- Heitmann B, Garby L: Patterns of Long-Term Weight Changes in Overweight Developing Danish Men and Women Aged Between 30 and 60 Years. Int J Obes. 1999, 23: 23-10.1038/sj.ijo.0800958.View ArticleGoogle Scholar
- Health Survey for England: [http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsStatistics/DH_4098712].
- Foxcroft DR: Orlistat for the treatment of obesity: cost utility model. Obes Rev. 2005, 6: 323-328. 10.1111/j.1467-789X.2005.00211.x.View ArticlePubMedGoogle Scholar
- Curtis L: Canterbury. Unit costs of health and social care. 2010, UK: University of KentGoogle Scholar
- Warren E, Brennan A, Akehurst R: Cost-Effectiveness of Sibutramine in the Treatment of Obesity. Medical Decision Making. 2004, 24: 9-19. 10.1177/0272989X03261565.View ArticlePubMedGoogle Scholar
- Ara R, Brennan A: The cost-effectiveness of sibutramine in non-diabetic obese patients: Evidence from four Western countries. Obes Rev. 2007, 8: 363-371. 10.1111/j.1467-789X.2007.00352.x.View ArticlePubMedGoogle Scholar
- Macran S: DP190 The Relationship between Body Mass Index and Health-Related Quality of Life. 2004, Centre for Health Economics Discussion Paper. York, In: University of YorkGoogle Scholar
- British National Formulary: [http://bnf.org/bnf/index.htm].
- Turnin MC, Bourgeois O, Cathelineau G, Leguerrier AM, Halimi S, Sandre-Banon D, Coliche V, Breux M, Verlet E, Labrousse F, et al: Multicenter randomized evaluation of a nutritional education software in obese patients. Diabetes Metab. 2001, 27 (2 Pt 1): 139-147.PubMedGoogle Scholar
- Jacobs N, Evers S, Ament A, Claes N: Cost-utility of a cardiovascular prevention program in highly educated adults: Intermediate results of a randomized controlled trial. Int J Technol Assessment in Health Care. 2010, 26 (01): 11-19. 10.1017/S0266462309990845.View ArticleGoogle Scholar
- Krukowski RA, Tilford JM, Harvey-Berino J: S. West D: Comparing Behavioral Weight Loss Modalities: Incremental Cost-Effectiveness of an Internet-Based Versus an In-Person Condition. Obesity. 2011, 19 (8): 1629-1635.PubMedGoogle Scholar
- Hersey JC, Khavjou O, Strange LB, Atkinson RL, Blair SN, Campbell S, Hobbs CL, Kelly B, Fitzgerald TM, Kish-Doto J, et al: The efficacy and cost-effectiveness of a community weight management intervention: A randomized controlled trial of the health weight management demonstration. Preventive Med. 2012, 54 (1): 42-49. 10.1016/j.ypmed.2011.09.018.View ArticleGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6963/12/190/prepub