Cost-effectiveness of six strategies for Helicobacter pyloridiagnosis and management in uninvestigated dyspepsia assuming a high resource intensity practice pattern
© Holmes et al; licensee BioMed Central Ltd. 2010
Received: 20 May 2010
Accepted: 21 December 2010
Published: 21 December 2010
Initial assessment of dyspepsia often includes noninvasive testing for Helicobacter pylori infection. Commercially available tests vary widely in cost and accuracy. Although there is extensive literature on the cost-effectiveness of H. pylori treatment, there is little information comparing the cost-effectiveness of various currently used, noninvasive testing strategies.
A Markov simulation was used to calculate cost per symptom-free year and cost per correct diagnosis. Uncertainty in outcomes was estimated using probabilistic sensitivity analysis.
Under the baseline assumptions, cost per symptom-free year was $122 for empiric proton pump inhibitor (PPI) trial, and costs for the noninvasive test strategies ranged from $123 (stool antigen) to $129 (IgG/IgA combined serology). Confidence intervals had significant overlap.
Under our assumptions for how testing for H. pylori infection is employed in United States medical practice, the available noninvasive tests all have similar cost-effectiveness between one another as well as with empiric PPI trial.
Many diagnostic scenarios require a physician to choose from among a set of related diagnostic tests. For Helicobacter pylori infection in the setting of dyspepsia, diagnostic options include serologic tests, a stool antigen test, a urea breath test, and invasive methods, such as endoscopy with biopsy. These options vary with regard to cost, convenience, and accuracy. The decision about which test to order may ultimately be a significant driver of downstream economic costs and quality-of-care outcomes. The American Gastroenterological Association (AGA) in 2005 recommended that to diagnose Helicobacter pylori infection in patients with dyspepsia, physicians should use either the stool antigen test or the urea breath test.[1, 2] Serologic tests were specifically not recommended due to inferior sensitivity and specificity. The American College of Gastroenterology (ACG) issued a similar guideline in 2007 that discussed the tradeoffs among available tests but left the test choice up to physician judgment. The testing volume for H. pylori at a national reference laboratory (ARUP Laboratories, Salt Lake City, Utah) suggests that serology is more widely used than would be expected under the AGA-recommended approach. ARUP received approximately four times as many orders for H. pylori serology between April 1, 2007, and March 31, 2008, than for either stool or breath tests. For this reason, serology is included in the current analysis.
A number of published articles address the cost-effectiveness of H. pylori management, but most of these primarily compare treatment options after a patient has already been diagnosed with H. pylori.[4–25] Others compare early endoscopy to empiric therapy and/or noninvasive testing.[26–32] Still others compare the effectiveness within a small subset of tests of diagnosing H. pylori infection or of determining the efficacy of treatment.[27–30, 33–43] At least one article has assessed cost-effectiveness of multiple noninvasive tests before and after diagnosis. Given that "test and treat" using noninvasive tests is a common approach to uninvestigated dyspepsia in the United States, the specific noninvasive test strategy becomes a key decision point. We therefore compared the cost-effectiveness of some of the most common noninvasive testing strategies for H. pylori along with empiric proton pump inhibitor (PPI) trial in the management of uninvestigated dyspepsia.
Description of strategies modeled.
Begin with H. pylori IgG and IgA tests. If either is positive, do triple therapy. If both are negative, do PPI trial.
Begin with H. pylori IgG test. If positive, do triple therapy. If negative, do PPI trial.
Begin with H. pylori stool antigen test. If positive, do triple therapy. If negative, do PPI trial.
IgG with reflex to stool Antigen
Begin with IgG test. If positive, confirm with stool antigen detection. If both tests are positive, do triple therapy. Otherwise, do PPI trial.
Begin with H. pylori urea breath test. If positive, do triple therapy. If negative, do PPI trial.
Skip noninvasive testing and begin instead with PPI trial.
The primary measure of outcome was the cost (US$) per symptom-free year. As the length of triple therapy or PPI trial is typically 14 days and this is the event of shortest duration in the model other than initial testing, the Markov cycle was defined as two weeks.
All patients enter the model with uninvestigated dyspepsia. There is some probability that the patient has an H. pylori infection, peptic ulcer(s), or both.
In keeping with AGA and ACG guidelines, the model considers only patients younger than 55 years of age who lack alarm features, such as bleeding or weight loss. Accordingly, the model does not consider the downstream costs or the medical consequences of gastric cancer, perforated ulcers, and other potentially life-threatening conditions.
Any patient who tests positive for H. pylori will be administered a course of standard triple therapy (clarithromycin, amoxicillin, and lansoprazole).
If there is no relief of symptoms after initial management, or if symptoms recur, he or she will go on to receive an endoscopy with a biopsy. This assumption was followed not in an attempt to reflect evidence-based practice, but rather in an attempt to reflect a "typical" approach to dyspepsia management.
Following endoscopy, if triple therapy or empiric PPI had been initially effective in relieving symptoms of dyspepsia, and if symptoms remained unresolved or recurred, the patient will receive long-term PPI therapy. As above, this assumption was followed in an attempt to reflect typical practice patterns, rather than evidence-based practice per se.
Patients remain in the model for the duration of their life.
Variables employed in the model.
95th percentile *
H. pylori prevalence
0.05 - 0.4
Initial ulcer status
Cost of IgA serology
Cost of IgG serology
Cost of stool Ag detection
Cost of urease breath test
Cost of endoscopy w/biopsy and pathologist time
Cost of eradication therapy
Cost of 2-week PPI therapy
Breath test sensitivity
0.90 - 0.98
Breath test specificity
0.94 - 0.99
IgA serology sensitivity
0.79 - 0.90
IgA serology specificity
0.65 - 0.85
IgG serology sensitivity
0.79 - 0.90
IgG serology specificity
0.65 - 0.85
Stool Ag sensitivity
0.90 - 0.99
Stool Ag specificity
0.90 - 0.99
Probability of relief of symptoms after two weeks of triple therapy (NUD§)
Probability of relief of symptoms after two weeks of triple therapy (PUD§§)
Probability of relief of symptoms after two-week PPI trial (NUD)
Probability of relief of symptoms after two-week PPI trial (PUD)
Probability of relapse at one year after eradication therapy (NUD)
Probability of relapse at one year after eradication therapy (PUD)
Probabilities employed in the model were based on published literature where available. Expert opinion was provided by one of the coauthors (JCF). Baseline costs of tests and treatments were based on 2009 national midpoint Medicare reimbursement rates. Second-order probabilistic sensitivity analysis, simulating 250 trials involving 10,000 patients each, was undertaken to measure the extent to which parameter uncertainty might affect the model outcomes. Incremental cost-effectiveness ratios (ICERs) were calculated based on a single simulated cohort of 500,000 patients using empiric PPI trial (i.e., no testing) as the baseline for comparison.
Cost-Effectiveness ratios for each strategy modeled.
Cost per symptom free year (95% CI*)
Empiric PPI Trial
IgG serology w/reflex to Stool Ag
IgG/IgA binary serology
Cost per correct diagnosis for each strategy modeled
Average Cost per Correct Diagnosis
IgG serology w/reflex to Stool Ag
IgG/IgA binary serology
Assuming that this model and its assumptions reasonably reflect U.S. clinical practice, it appears that the initial choice of noninvasive testing strategy does not have a significant influence on the overall cost-effectiveness of care for patients presenting with previously uninvestigated dyspepsia. This finding holds even when the prevalence of H. pylori infection is varied over a wide range (5% to 40%).
These findings may seem surprising; it seems intuitive that more accurate testing should lead to improved outcomes and lower overall health spending, provided that the cost of the test itself is reasonable. The key, though, is the set of baseline assumptions about how the tests are used in U.S. clinical practice. In particular, we assumed that in the absence of symptomatic relief, physicians would move fairly quickly to definitive diagnosis (endoscopy with biopsy), thus reducing or even negating the impact of the original noninvasive test (or lack thereof). To use a more extreme illustration, a consequence of our underlying model is that the diagnostic test could be replaced with a random number generator without significantly impacting cost-effectiveness. In settings where endoscopy is less widely employed, the decision about which noninvasive test to order for a patient would likely have a larger economic and clinical impact, depending on the test chosen.
Vakil et al. estimated the cost-effectiveness of a similar set of noninvasive testing strategies in a 2000 paper . In their model, cost per correct diagnosis using the antibody and stool tests ranged from $90 to $127. The antibody tests incurred the lowest cost per correct diagnosis at all levels of prevalence that they modeled (30%, 60%, and 90%). The stool test was more expensive at low and intermediate prevalence, but with much higher diagnostic accuracy (~93%). A key distinction of our model is that we used cost per symptom-free year rather than cost per correct diagnosis as our primary measure, although we did include the latter in our results for comparison. This distinction is significant. First, the clinical goal is typically relief of symptoms rather than diagnosis per se. A patient is unlikely to undergo follow-up when symptoms have been alleviated, as in the empiric PPI trial or a PPI trial after eradication treatment. The impact of the diagnosis can only be truly assessed in the context of the resulting clinical actions. Therefore, the cost at diagnosis does not reflect the total cost of care. For example, a patient can have an incorrect noninvasive test result, but if the patient still achieves long-term relief of symptoms without incurring too much expense, then from that patient's
perspective, no great harm has been done. We thus believe that cost per symptom-free year is a more appropriate cost-effectiveness measure than cost per correct diagnosis. In a larger sense, our study illustrates some of the challenges in assessing cost-effectiveness of diagnostic tests, as well as the importance of doing so. Because testing is an upstream process, the clinical and economic impacts of diagnostic tests are expressed primarily in the downstream clinical actions. The result from a $10 test, for example, might in some cases make the difference between whether to provide a $10,000 course of chemotherapy or a surgical procedure. Or, in a different scenario, that same $10 test might simply be a waste of $10, if the same clinical actions took place regardless of the test result. Superior sensitivity and/or specificity does not guarantee better patient outcomes once the test is placed in the larger context of patient management. In other words, cost-effectiveness is less an inherent property of a particular test than it is a property of the decision-making algorithm in which that test is employed.
The primary limitation of our analysis was our set of clinical assumptions. These results should not be considered to have validity outside of those assumptions. This includes both the assumed practice pattern (Figure 1) and the numbers (costs and probabilities). In clinical settings that do not fit these assumptions our results may not apply. Another limitation is that we did not present our results in terms of quality-adjusted life years (QALYs), partly because we did not find any widely used figures for quality-of-life measurements for patients with dyspepsia, and partly because the existing literature on cost-effectiveness of H. pylori diagnostic tests does not appear to rely heavily on QALY analysis. Also, as stated above, our model was based entirely on dyspepsia relief and did not consider more serious illnesses such as a perforated ulcer, gastric cancer, etc.
Finally, our analysis relied heavily on the findings of a Cochrane systematic review in which H. pylori eradication was found to have only a very small clinical benefit for the average patient with nonulcer dyspepsia. Our findings may thus not apply to patient subsets for which eradication therapy could be shown to have a larger average benefit.
In this model of H. pylori diagnosis and treatment, the choice of initial noninvasive test did not have a significant impact on cost or quality outcome. This is likely attributable to the assumption of a high resource intensity practice environment. In practice settings where endoscopy is less available and/or less readily employed, these findings may not apply.
- Talley NJ, Vakil NB, Moayyedi P: American gastroenterological association technical review on the evaluation of dyspepsia. Gastroenterology. 2005, 129 (5): 1756-80. 10.1053/j.gastro.2005.09.020.View ArticlePubMedGoogle Scholar
- Talley NJ: American Gastroenterological Association medical position statement: evaluation of dyspepsia. Gastroenterology. 2005, 129 (5): 1753-5. 10.1053/j.gastro.2005.09.019.View ArticlePubMedGoogle Scholar
- Chey WD, Wong BC: American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol. 2007, 102 (8): 1808-25. 10.1111/j.1572-0241.2007.01393.x.View ArticlePubMedGoogle Scholar
- Adamsson I, Nord CE, Lundquist P, Sjostedt S, Edlund C: Comparative effects of omeprazole, amoxycillin plus metronidazole versus omeprazole, clarithromycin plus metronidazole on the oral, gastric and intestinal microflora in Helicobacter pylori-infected patients. J Antimicrob Chemother. 1999, 44 (5): 629-40. 10.1093/jac/44.5.629.View ArticlePubMedGoogle Scholar
- Adamsson I, Edlund C, Nord CE: Impact of treatment of Helicobacter pylori on the normal gastrointestinal microflora. Clin Microbiol Infect. 2000, 6 (4): 175-7. 10.1111/j.1469-0691.2000.00028.x.View ArticlePubMedGoogle Scholar
- Calvet X, Gene E, Lopez T, Gisbert JP: What is the optimal length of proton pump inhibitor-based triple therapies for H. pylori? A cost-effectiveness analysis. Aliment Pharmacol Ther. 2001, 15 (7): 1067-76. 10.1046/j.1365-2036.2001.01031.x.View ArticlePubMedGoogle Scholar
- Childs S, Roberts A, Meineche-Schmidt V, de WN, Rubin G: The management of Helicobacter pylori infection in primary care: a systematic review of the literature. Fam Pract. 2000, 17 (Suppl 2): S6-11. 10.1093/fampra/17.suppl_2.S6.View ArticlePubMedGoogle Scholar
- Choi J, Jang JY, Kim JS, Park HY, Choe YH, Kim KM: Efficacy of two triple eradication regimens in children with Helicobacter pylori infection. J Korean Med Sci. 2006, 21 (6): 1037-40. 10.3346/jkms.2006.21.6.1037.View ArticlePubMedPubMed CentralGoogle Scholar
- Cutler AF, Vakil N: Evolving therapy for Helicobacter pylori infection: efficacy and economic impact in the treatment of patients with duodenal ulcer disease. Am J Manag Care. 1997, 3 (10): 1528-34.PubMedGoogle Scholar
- Duggan AE, Tolley K, Hawkey CJ, Logan RF: Varying efficacy of Helicobacter pylori eradication regimens: cost effectiveness study using a decision analysis model. BMJ. 1998, 316 (7145): 1648-54.View ArticlePubMedPubMed CentralGoogle Scholar
- Ford AC, Delaney BC, Forman D, Moayyedi P: Eradication therapy in Helicobacter pylori positive peptic ulcer disease: systematic review and economic analysis. Am J Gastroenterol. 2004, 99 (9): 1833-55. 10.1111/j.1572-0241.2004.40014.x.View ArticlePubMedGoogle Scholar
- Laine L, Schoenfeld P, Fennerty MB: Therapy for Helicobacter pylori in patients with nonulcer dyspepsia. A meta-analysis of randomized, controlled trials. Ann Intern Med. 2001, 134 (5): 361-9.View ArticlePubMedGoogle Scholar
- Malfertheiner P, Megraud F, O'Morain C, Hungin AP, Jones R, Axon A, et al: Current concepts in the management of Helicobacter pylori infection--the Maastricht 2-2000 Consensus Report. Aliment Pharmacol Ther. 2002, 16 (2): 167-80. 10.1046/j.1365-2036.2002.01169.x.View ArticlePubMedGoogle Scholar
- Malfertheiner P, Megraud F, O'Morain C, Bazzoli F, El-Omar E, Graham D, et al: Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut. 2007, 56 (6): 772-81. 10.1136/gut.2006.101634.View ArticlePubMedGoogle Scholar
- McColl KE, Dickson A, El-Nujumi A, El-Omar E, Kelman A: Symptomatic benefit 1-3 years after H. pylori eradication in ulcer patients: impact of gastroesophageal reflux disease. Am J Gastroenterol. 2000, 95 (1): 101-5.PubMedGoogle Scholar
- McColl KE: Helicobacter pylori infection and long term proton pump inhibitor therapy. Gut. 2004, 53 (1): 5-7. 10.1136/gut.53.1.5.View ArticlePubMedPubMed CentralGoogle Scholar
- Moayyedi P, Soo S, Deeks J, Forman D, Mason J, Innes M, et al: Systematic review and economic evaluation of Helicobacter pylori eradication treatment for non-ulcer dyspepsia. Dyspepsia Review Group. BMJ. 2000, 321 (7262): 659-64. 10.1136/bmj.321.7262.659.View ArticlePubMedPubMed CentralGoogle Scholar
- Moayyedi P, Deeks J, Talley NJ, Delaney B, Forman D: An update of the Cochrane systematic review of Helicobacter pylori eradication therapy in nonulcer dyspepsia: resolving the discrepancy between systematic reviews. Am J Gastroenterol. 2003, 98 (12): 2621-6. 10.1111/j.1572-0241.2003.08724.x.View ArticlePubMedGoogle Scholar
- Raghunath AS, Hungin AP, Wooff D, Childs S: Systematic review: the effect of Helicobacter pylori and its eradication on gastro-oesophageal reflux disease in patients with duodenal ulcers or reflux oesophagitis. Aliment Pharmacol Ther. 2004, 20 (7): 733-44. 10.1111/j.1365-2036.2004.02172.x.View ArticlePubMedGoogle Scholar
- Sonnenberg A, Pauly MP, Levenson SD, Schwartz JS: Antibiotic therapy of Helicobacter pylori infection reduces healthcare expenditures related to duodenal ulcer. Am J Manag Care. 1999, 5 (1): 53-9.PubMedGoogle Scholar
- Spiegel BM, Vakil NB, Ofman JJ: Dyspepsia management in primary care: a decision analysis of competing strategies. Gastroenterology. 2002, 122 (5): 1270-85. 10.1053/gast.2002.33019.View ArticlePubMedGoogle Scholar
- Talley NJ, Vakil N: Guidelines for the management of dyspepsia. Am J Gastroenterol. 2005, 100 (10): 2324-37. 10.1111/j.1572-0241.2005.00225.x.View ArticlePubMedGoogle Scholar
- Tytgat GN: Treatment of Helicobacter pylori infection: management of patients with ulcer disease by general practitioners and gastroenterologists. Gut. 1998, 43 (Suppl 1): S24-S26. 10.1136/gut.43.2008.S24.View ArticlePubMedPubMed CentralGoogle Scholar
- Vakil N, Connor J: Helicobacter pylori eradication: equivalence trials and the optimal duration of therapy. Am J Gastroenterol. 2005, 100 (8): 1702-3. 10.1111/j.1572-0241.2005.50615.x.View ArticlePubMedGoogle Scholar
- Vakil N, Megraud F: Eradication therapy for Helicobacter pylori. Gastroenterology. 2007, 133 (3): 985-1001. 10.1053/j.gastro.2007.07.008.View ArticlePubMedGoogle Scholar
- Chey WD, Fendrick AM: Noninvasive Helicobacter pylori testing for the "testand-treat" strategy: a decision analysis to assess the effect of past infection on test choice. Arch Intern Med. 2001, 161 (17): 2129-32. 10.1001/archinte.161.17.2129.View ArticlePubMedGoogle Scholar
- Demiray E, Yilmaz O, Sarkis C, Soyturk M, Simsek I: Comparison of invasive methods and two different stool antigen tests for diagnosis of H pylori infection in patients with gastric bleeding. World J Gastroenterol. 2006, 12 (26): 4206-10.View ArticlePubMedPubMed CentralGoogle Scholar
- Gee I, Playford RJ, Turner D, Sheldon N, Wicks AC: Cost analysis of breath test versus endoscopy for dyspepsia. Digestion. 2002, 65 (4): 207-12. 10.1159/000063821.View ArticlePubMedGoogle Scholar
- Hsu PI, Lai KH, Tseng HH, Liu YC, Yen MY, Lin CK, et al: Correlation of serum immunoglobulin G Helicobacter pylori antibody titers with histologic and endoscopic findings in patients with dyspepsia. J Clin Gastroenterol. 1997, 25 (4): 587-91. 10.1097/00004836-199712000-00007.View ArticlePubMedGoogle Scholar
- Lehmann F, Drewe J, Terracciano L, Stuber R, Frei R, Beglinger C: Comparison of stool immunoassay with standard methods for detecting Helicobacter pylori infection. BMJ. 1999, 319 (7222): 1409.View ArticlePubMedPubMed CentralGoogle Scholar
- Ogata SK, Kawakami E, Patricio FR, Pedroso MZ, Santos AM: Evaluation of invasive and non-invasive methods for the diagnosis of Helicobacter pylori infection in symptomatic children and adolescents. Sao Paulo Med J. 2001, 119 (2): 67-71. 10.1590/S1516-31802001000200006.View ArticlePubMedGoogle Scholar
- Zaitoun AM: Histology compared with chemical testing for urease for rapid detection of Helicobacter pylori in gastric biopsy specimens. J Clin Pathol. 1993, 46 (7): 684-5. 10.1136/jcp.46.7.684.View ArticlePubMedPubMed CentralGoogle Scholar
- Andrews J, Marsden B, Brown D, Wong VS, Wood E, Kelsey M: Comparison of three stool antigen tests for Helicobacter pylori detection. J Clin Pathol. 2003, 56 (10): 769-71. 10.1136/jcp.56.10.769.View ArticlePubMedPubMed CentralGoogle Scholar
- Braden B, Teuber G, Dietrich CF, Caspary WF, Lembcke B: Comparison of new faecal antigen test with (13)C-urea breath test for detecting Helicobacter pylori infection and monitoring eradication treatment: prospective clinical evaluation. BMJ. 2000, 320 (7228): 148-10.1136/bmj.320.7228.148.View ArticlePubMedPubMed CentralGoogle Scholar
- Gisbert JP, Trapero M, Pajares JM: Evaluation of 3 different tests for the detection of stool antigens to confirm Helicobacter pylori eradication after treatment. A pilot study. Gastroenterol Hepatol. 2005, 28 (10): 615-8. 10.1016/S0210-5705(05)71524-7.View ArticlePubMedGoogle Scholar
- Laine L, Suchower L, Johnson E, Ronca P, Neil G: Accuracy of CLOtest after Helicobacter pylori therapy. Gastrointest Endosc. 1998, 47 (3): 250-3. 10.1016/S0016-5107(98)70321-9.View ArticlePubMedGoogle Scholar
- Li YH, Guo H, Zhang PB, Zhao XY, Da SP: Clinical value of Helicobacter pylori stool antigen test, ImmunoCard STAT HpSA, for detecting H pylori infection. World J Gastroenterol. 2004, 10 (6): 913-4.PubMedPubMed CentralGoogle Scholar
- Reilly TG, Poxon V, Sanders DS, Elliott TS, Walt RP: Comparison of serum, salivary, and rapid whole blood diagnostic tests for Helicobacter pylori and their validation against endoscopy based tests. Gut. 1997, 40 (4): 454-8.View ArticlePubMedPubMed CentralGoogle Scholar
- Sabbi T, De AP, Colistro F, Dall'Oglio L, di Abriola GF, Castro M: Efficacy of noninvasive tests in the diagnosis of Helicobacter pylori infection in pediatric patients. Arch Pediatr Adolesc Med. 2005, 159 (3): 238-41. 10.1001/archpedi.159.3.238.View ArticlePubMedGoogle Scholar
- Shepherd AJ, Williams CL, Doherty CP, Hossack M, Preston T, McColl KE, et al: Comparison of an enzyme immunoassay for the detection of Helicobacter pylori antigens in the faeces with the urea breath test. Arch Dis Child. 2000, 83 (3): 268-70. 10.1136/adc.83.3.268.View ArticlePubMedPubMed CentralGoogle Scholar
- Vaira D, Vakil N: Blood, urine, stool, breath, money, and Helicobacter pylori. Gut. 2001, 48 (3): 287-9. 10.1136/gut.48.3.287.View ArticlePubMedPubMed CentralGoogle Scholar
- Vaira D, Vakil N, Menegatti M, van't HB, Ricci C, Gatta L, et al: The stool antigen test for detection of Helicobacter pylori after eradication therapy. Ann Intern Med. 2002, 136 (4): 280-7.View ArticlePubMedGoogle Scholar
- Veijola L, Myllyluoma E, Korpela R, Rautelin H: Stool antigen tests in the diagnosis of Helicobacter pylori infection before and after eradication therapy. World J Gastroenterol. 2005, 11 (46): 7340-4.View ArticlePubMedPubMed CentralGoogle Scholar
- Vakil N, Rhew D, Soll A, Ofman JJ: The cost-effectiveness of diagnostic testing strategies for Helicobacter pylori. Am J Gastroenterol. 2000, 95 (7): 1691-8.PubMedGoogle Scholar
- Mushlin AI, Ruchlin HS, Callahan MA: Costeffectiveness of diagnostic tests. Lancet. 2001, 358 (9290): 1353-5. 10.1016/S0140-6736(01)06417-0.View ArticlePubMedGoogle Scholar
- Raghunath A, Hungin AP, Wooff D, Childs S: Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: systematic review. BMJ. 2003, 326 (7392): 737-10.1136/bmj.326.7392.737.View ArticlePubMedPubMed CentralGoogle Scholar
- Crabtree JE, Shallcross TM, Heatley RV, Wyatt JI: Evaluation of a commercial ELISA for serodiagnosis of Helicobacter pylori infection. J Clin Pathol. 1991, 44 (4): 326-8. 10.1136/jcp.44.4.326.View ArticlePubMedPubMed CentralGoogle Scholar
- Duggan A, Logan R: Validation of a rapid whole blood test for diagnosing Helicobacter pylori infection. Conflicting results from the Helisal test. BMJ. 1997, 314 (7095): 1688-9.View ArticlePubMedPubMed CentralGoogle Scholar
- Karvar S, Karch H, Frosch M, Burghardt W, Gross U: Use of serum-specific immunoglobulins A and G for detection of Helicobacter pylori infection in patients with chronic gastritis by immunoblot analysis. J Clin Microbiol. 1997, 35 (12): 3058-61.PubMedPubMed CentralGoogle Scholar
- Talley NJ, Newell DG, Ormand JE, Carpenter HA, Wilson WR, Zinsmeister AR, et al: Serodiagnosis of Helicobacter pylori: comparison of enzyme-linked immunosorbent assays. J Clin Microbiol. 1991, 29 (8): 1635-9.PubMedPubMed CentralGoogle Scholar
- van Der EA, van Der Hulst RW, Roorda P, Tytgat GN, Dankert J: Evaluation of three commercial serological tests with different methodologies to assess Helicobacter pylori infection. J Clin Microbiol. 1999, 37 (12): 4150-2.Google Scholar
- Erzin Y, Altun S, Dobrucali A, Aslan M, Erdamar S, Dirican A, et al: Evaluation of two enzyme immunoassays for detecting Helicobacter pylori in stool specimens of dyspeptic patients after eradication therapy. J Med Microbiol. 2005, 54 (Pt 9): 863-6. 10.1099/jmm.0.45914-0.View ArticlePubMedGoogle Scholar
- Gisbert JP, Pajares JM: Diagnosis of Helicobacter pylori infection by stool antigen determination: a systematic review. Am J Gastroenterol. 2001, 96 (10): 2829-38. 10.1111/j.1572-0241.2001.04235.x.View ArticlePubMedGoogle Scholar
- Gisbert JP, Pajares JM: Stool antigen test for the diagnosis of Helicobacter pylori infection: a systematic review. Helicobacter. 2004, 9 (4): 347-68. 10.1111/j.1083-4389.2004.00235.x.View ArticlePubMedGoogle Scholar
- Gisbert JP, de la MF, Abraira V: Accuracy of monoclonal stool antigen test for the diagnosis of H. pylori infection: a systematic review and meta-analysis. Am J Gastroenterol. 2006, 101 (8): 1921-30. 10.1111/j.1572-0241.2006.00668.x.View ArticlePubMedGoogle Scholar
- Syam AF, Rani AA, Abdullah M, Manan C, Makmun D, Simadibrata M, et al: Accuracy of Helicobacter pylori stool antigen for the detection of Helicobacter pylori infection in dyspeptic patients. World J Gastroenterol. 2005, 11 (3): 386-8.View ArticlePubMedPubMed CentralGoogle Scholar
- Moayyedi P, Soo S, Deeks J, Delaney B, Harris A, Innes M, et al: Eradication of Helicobacter pylori for non-ulcer dyspepsia. Cochrane Database Syst Rev. 2006, CD002096-2Google Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6963/10/344/prepub
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