Modeling the volume-effectiveness relationship in the case of hip fracture treatment in Finland
© Sund; licensee BioMed Central Ltd. 2010
Received: 19 March 2010
Accepted: 13 August 2010
Published: 13 August 2010
A common argument in the recent health policy debate is that treatment is more effective among care providers with large volumes. It is challenging, however, to examine the volume-effectiveness relationship empirically. Several suggestions have recently been made for methodological improvements in the examination of the volume-effectiveness relationship. The aim of this study is to develop an extended methodology for examining the volume-effectiveness relationship and demonstrate it for the case of hip fracture treatment.
Data consisting of 22,857 hip fracture patients from 52 hospitals in Finland in 1998-2001 were extracted from the administrative registers. The relationship between hospital and rehabilitation unit volumes and effectiveness was examined using a statistical model that allowed risk adjustments and hierarchical modeling of volume trends, developed for the purposes of this study. Four-month mortality and the alternative register-based measure of maintainability were used as effectiveness indicators.
No clear relationship was found between hospital volume and the effectiveness of hip fracture treatment, but a novel result showing an association between the rehabilitation unit volume and effectiveness was detected. The face validity of the maintainability indicator seemed to be acceptable.
The methodological ideas presented allow for improved examination of the volume-effectiveness relationship. There are no indications that patients with hip fractures should only be treated in high-volume hospitals, though it may be beneficial to centralize the rehabilitation of hip fracture patients to specialized units.
A common argument in the recent health policy debate is that treatment is more effective among care providers with large volumes. A wealth of empirical evidence also demonstrates improved effectiveness with selected procedures at high-volume hospitals and by high-volume surgeons [1–4]. It has been suggested that experience or routine (individual and organizational learning), patient selection (better outcomes lead to higher volumes), and the availability of supplementary services (more structure-related resources) may play a part in the relationship between volume and effectiveness, and many of these aspects probably hold true across several health system implementations [5–8]. It has been claimed, however, that the health care provider volume is a nonspecific, indirect, and unreliable measure of provider performance, and a causal relationship between volume and effectiveness has not been proved to exist . In any case, by assuming that the volume-effectiveness relationships are due to human behavior and organizational factors, it is obvious that the interpretations of associations are conditional to the context of observation. In other words, any health policy decision-making related to the volume-effectiveness relationship should be sensitive to potential problems in order to avoid uncritical generalization of international evidence .
There have also been methodological drawbacks in the studies that have examined the volume-effectiveness relationship, and several suggestions for methodological improvements have recently been pointed out [11–13]. First, risk adjustment must be considered in the analyses. Second, as the possible volume effect reflects the process of care, some other measure for effectiveness than the most commonly used mortality event - which is a rather crude proxy for effectiveness - should be used . The third issue is to consider the hierarchical nature of the volume effect. While effectiveness should be analyzed at patient level, allowing adequate risk-adjustment, the volume effect must be analyzed at provider level . Moreover, the type of volume relationship (curve-linear, linear, stepwise, cut-off) and the effect of clustering (representing variations in outcomes among providers with similar volumes) should be carefully considered in the model [12, 13]. The fourth problem is related to the chance variability of the effectiveness measure. The effectiveness measure (such as mortality) is typically such a rare event that at some providers there may be no or only a few actual events during the observation period. As even one or two events may significantly alter the observed results of low-volume providers, sophisticated hierarchical statistical models should be used that allow conservative shrinkage toward the mean of similar providers [11, 13].
Aim of the study
The aim of this study is to develop an extended methodology for examining the volume-effectiveness relationship. The application of the methodology is demonstrated in the case of hip fracture treatment in the Finnish context by using register-based data.
In Finland, reliable provider-specific information about the effectiveness of treatments has been considered the only way to monitor the progress of centralization and constitute justified limits for the sizes of practically reasonable units in the Finnish health care system .
The organization of social and health care - both of which are incorporated into the same national planning and tax-based financing system - has long been considered a public responsibility in Finland . The country's numerous local authorities - municipalities - are responsible for arranging primary care and other basic services, such as nursing homes and other social services for the elderly . In addition, each municipality is a member of one of the 21 hospital district joint authorities that are responsible for organizing specialized medical services and coordinating hospital treatment in their own districts. Primary health care is mainly provided at health centers that are owned by municipalities or federations of municipalities. The health centers also contain inpatient wards that are mainly used by elderly and chronically ill patients. Secondary and tertiary level medical care is provided by a hierarchy of hospitals, including about forty regional hospitals, sixteen central hospitals, and five university teaching hospitals . Publicly owned hospitals are not run for profit, and there are only a few private hospitals in Finland.
In regard to hip fracture treatment, virtually all hip fracture patients are first referred for examination and surgical treatment to the nearest public hospital with orthopedic services in Finland. After very short postoperative hospital treatment, a hip fracture patient is typically transferred for rehabilitation to the health center . Other services used by hip fracture patients include nursing home care, outpatient health services, and home-help services. Patients have very limited possibilities to choose treatment units, as these are determined based on the patient's municipality of residence.
In the case of hip fracture treatment, there are two volume-related factors that can be regulated fairly easily: the number of orthopedic treatment units and the number of rehabilitation units. The main policy-relevant question can be stated as: Is it possible to improve the effectiveness of hip fracture treatment by regulating the minimum volume for the treatment units?
In order to examine the volume-effectiveness relationship, data on comparatively risk-adjusted effectiveness indicators are needed for all care providers. The amount of data required is so massive that administrative registers are the only realistic source of such data, in spite of their known shortcomings, such as their secondary nature and the lack of clinical data for risk-adjustment purposes [19, 20]. In Finland, very good administrative registers are available, and the personal identification number allows deterministic record-linkage within and between registers. In general, the complete registration, combined with easily linkable registers, makes large, longitudinal population-based studies feasible in Finland .
For the purposes of this study, the total population of hip fracture patients in 1998-2001 was identified in the Finnish Health Care Register. The medical histories (1987-2002) and deaths (1998-2002) of the hip fracture population were extracted from the Finnish Hospital Discharge Register, the Finnish Health and Social Welfare Care Register, and the National Causes of Death statistics using the unique personal identification codes of the patient population. Each record in these registers includes data such as patient and provider ID numbers, age, sex, area codes, and diagnosis and operation codes, as well as dates of admission, operation, and discharge (or death). The validity of Finnish register-data for studying the effectiveness of hip fracture treatment is known to be good .
Data were pre-processed so that the information concerning hip fracture patients with their first hip fracture could be accurately identified. The details of the process are reported elsewhere . The existence of possible comorbidities was extracted for each patient from his or her medical history using the diagnosis codes recorded in the data. The extraction method was adapted from the Charlson comorbidity categories, and the application to the current data set was done in a similar fashion to that of previous hip fracture studies [24–26]. Other relevant variables available in register-based data, such as age, sex, source of admission, and prior use of care, were also extracted from the data for risk adjustment purposes.
The data set used in this study included data for 22,857 hip fracture patients from 52 hospitals. The volume-effectiveness relationship for rehabilitation units was investigated using a subset of data including hip fracture patients aged 65 years and older who lived at home before the fracture. This subset included 10,384 patients who were transferred to a rehabilitation unit (n = 272) after an operation.
While using data from administrative registers, only a limited number of validated effectiveness indicators are available. The most common one is mortality. The use of short-term mortality as an effectiveness measure in volume-effectiveness studies has been criticized, however, because it is a rather crude proxy for effectiveness and also a rather uncommon event that may cause problems in statistical modeling . Moreover, short-term mortality is a weak effectiveness indicator in the sense that many of the perioperative deaths of hip fracture patients may be unavoidable . Four-month mortality was therefore selected as a primary effectiveness indicator in this study. The limit of four months corresponds to the population level maximum for the length of the acute hip fracture treatment episode .
There are other possible effectiveness indicators, such as re-hospitalizations or the occurrence of complications. Unfortunately, the indicators that require complex data abstraction using diagnosis codes, such as in the identification of complications, are prone to severe bias caused by existing differences in the registration practices of (secondary) diagnoses. It has been shown, however, that the Finnish register data allow a complete reconstruction of hip fracture treatment episodes in terms of daily levels of care, for which the directly observable levels of care are: 1) home (including home care, ordinary service houses, and outpatient care), 2) nursing home (service houses with 24-hour assistance and residential homes), 3) health center (inpatient ward of local primary care unit), 4) hospital, and 5) death . It is also known that each level of care reflects a certain intensity and need for care . In this sense, it can be interpreted that the directly observable backward steps in the levels of (inpatient) care in the treatment episode following the hip fracture reflect an increased need for care, i.e., obvious drops in the health status of the patient. For the purposes of this study, a new effectiveness measure of maintainability was defined: maintainability can be considered satisfactory if no backward steps are observed in the levels of care. In practice, this measure describes whether there have been some unexpected steps during the treatment (by capturing deaths, readmissions, and referrals to higher-level hospitals). Here, maintainability was operationalized as a dummy variable that indicates unsuccessful maintainability if an event that breaks maintainability was observed during the first four months after the hip fracture.
Basic model for the volume-effectiveness relationship
The basic idea in volume-effectiveness analyses is to compare the effectiveness of treatment between providers (such as hospitals). This kind of activity is commonly referred to as profiling of providers. Profiling can be quite complicated, as there is variation between providers for at least three reasons: 1) differences may be attributable to random variation due to the size of the provider, 2) the patient case-mix varies from provider to provider, and 3) providers may differ in the effectiveness of their care . For these reasons, a statistical model for provider profiling, in which provider differences are modeled explicitly, must be considered for justified conclusions.
where the sums are over j patients treated by provider i, while β is an estimated parameter vector .
and i is the provider index . In other words, it is assumed that the expected outcomes Ei adjust the patient characteristics, and θi describes the variation caused by the provider. The use of logarithms guarantees that θi remains positive in this kind of random effects model.
Extended model for the volume-effectiveness relationship
Hierarchical models, similar to the one presented above, are widely applied in provider profiling and are known to be superior to non-hierarchical models . Unfortunately, the presented model is not optimal for the investigation of a possible relationship between effectiveness and volume because the observations are shrunk towards the global mean, even though it can be hypothesized that there will be some kind of trend between the volume and provider-specific effectiveness measures. In fact, it has been hypothesized that the relationship between volume and effectiveness may be non-linear, linear, stepwise, or may have a single cut-off .
In the model presented above, the logarithm of the ratio between observed and expected outcomes was used as a convenient starting point for the model. This means that technically, it would be convenient to incorporate also the possibility of a trend on the logarithmic scale. In fact, the ratio between observed and expected outcomes is a measure of relative difference, and the log difference is the preferred scale for such measures . It is also known that the relative difference approximates to the more adequate log-difference measure in the proximity of ratio one, which means that the interpretations are approximately equal, if the differences are quite small.
In principle, the same model works in the single cut-off case: if zi is changed to a dummy-variable indicating the "high-volume" provider. Similarly, a stepwise model could be implemented by adding regression parameters and dummy variables to the model. The practical problem for the non-continuous models is the determination of appropriate cut points. It is possible to use predetermined limits or try to estimate optimal cut points with the data . With the hierarchical full probability models, it would be possible to build a model for the single cut-off case where the cut-off point is treated as a parameter that is estimated simultaneously with the other parameters. Such a model, however, is not considered here because the estimation easily results in multimodal posterior distributions.
The extension of the model to incorporate a non-linear trend is a little more challenging. The simple parametric approach of using low-order polynomials in the regression model offers only a limited family of shapes and, with more complex forms, it is typically very difficult to choose between well-fitting models. In principle, regression using the fractional polynomial approach could be a satisfactory compromise but would require the fitting of numerous regression models . With the hierarchical modeling approach, it is actually more tempting to use the recently invented connection between penalized splines and linear mixed models to extend the standard regression model to a semi-parametric form in which the non-linear relationship is not restricted by the parametric forms . The aim of such models is to describe the local structure of the relationship between outcome and covariate, resulting in a good fit across the range of the covariate.
Application of the models
In this study, the three different volume models described above - a mean model, a linear trend model, and a spline model - were applied to the examination of the volume-effectiveness relationship between the four-year (1998-2001) pooled hospital or rehabilitation unit volume and two effectiveness measures, four-month mortality, and maintainability. The predicted probabilities of mortality and maintainability required for risk-adjustment purposes were estimated using the logistic regression model, and the predictive power of the model was measured using the c-statistics. The hierarchical models were estimated using MCMC simulation. Five knots were used in the specification of the spline model. The mixing of the estimation procedure was examined using two chains in the estimation, and the convergence was evaluated on the basis of Gelman-Rubin convergence plots . A hundred thousand iterations following ten thousand burn-in iterations were used in the actual estimation of the parameters for each model. The complexity and relative fit of the hierarchical models were assessed with the deviance information criterion (DIC) .
Basic characteristics and factors predicting four-month mortality and maintainability among hip fracture patients in Finland, years 1998-2001
All hip fracture patients
OR (95% CI)
OR (95% CI)
OR (95% CI)
OR (95% CI)
Number of observations
Number of events
1.91 (1.83 to 2.00)
1.21 (1.19 to 1.24)
2.04 (1.87 to 2.22)
1.27 (1.20 to 1.35)
2.11 (1.95 to 2.28)
1.50 (1.41 to 1.60)
1.97 (1.74 to 2.22)
1.52 (1.39 to 1.67)
Type of fracture
Neck of femur
1.01 (0.94 to 1.09)
0.93 (0.87 to 0.98)
1.00 (0.89 to 1.13)
0.89 (0.82 to 0.97)
1.12 (0.97 to 1.30)
1.03 (0.92 to 1.15)
1.07 (0.86 to 1.33)
0.90 (0.76 to 1.05)
Long-term care patient
1.02 (0.93 to 1.12)
0.60 (0.55 to 0.65)
Recent short-term care
No recent care
0.46 (0.43 to 0.50)
0.54 (0.51 to 0.58)
0.40 (0.35 to 0.46)
0.58 (0.51 to 0.65)
1.68 (1.53 to 1.86)
1.46 (1.34 to 1.59)
1.77 (1.53 to 2.05)
1.47 (1.30 to 1.66)
1.33 (1.19 to 1.48)
1.40 (1.28 to 1.53)
1.25 (1.06 to 1.48)
1.40 (1.23 to 1.60)
1.14 (0.95 to 1.38)
1.30 (1.11 to 1.53)
1.22 (0.90 to 1.65)
1.55 (1.23 to 1.97)
1.50 (1.39 to 1.61)
1.38 (1.30 to 1.47)
1.32 (1.18 to 1.48)
1.28 (1.17 to 1.39)
1.14 (1.05 to 1.24)
1.15 (1.07 to 1.23)
1.24 (1.08 to 1.41)
1.22 (1.10 to 1.36)
Peripheral vascular disease
1.20 (1.04 to 1.40)
1.28 (1.12 to 1.46)
1.56 (1.25 to 1.95)
1.55 (1.28 to 1.87)
Chronic pulmonary disease
1.24 (1.11 to 1.39)
1.30 (1.18 to 1.44)
1.27 (1.06 to 1.51)
1.32 (1.15 to 1.52)
Peptic ulcer disease
1.08 (0.91 to 1.28)
1.25 (1.08 to 1.44)
1.17 (0.90 to 1.52)
1.28 (1.04 to 1.56)
2.05 (1.52 to 2.76)
1.98 (1.47 to 2.67)
1.83 (1.15 to 2.91)
1.84 (1.18 to 2.86)
0.96 (0.81 to 1.13)
1.21 (1.07 to 1.36)
0.99 (0.78 to 1.25)
1.34 (1.14 to 1.59)
The average four-month mortality among all hip fracture patients was 18.8% and the average unsuccessful maintainability was 43.7%. Of the 9,991 first events of unsuccessful maintainability, 3,275 (32.8%) were deaths, 3,522 (35.3%) readmissions, and 3,194 (32.0%) referrals to higher-level providers. The corresponding figures for the subset of patients treated in rehabilitation units were 16.5% for mortality and 46.5% for unsuccessful maintainability, and of the 4,833 first events of unsuccessful maintainability, 1,153 (23.9%) were deaths, 1,754 (36.3%) were readmissions, and 1,926 (39.9%) were referrals to higher-level providers.
The odds ratios from the logistic regression models used in risk adjustment are also reported in Table 1. The effects of age and sex were stronger in the mortality models than in the maintainability models. Comorbid conditions had a tendency to slightly stronger effects in the maintainability models than in the mortality models except for renal and vascular diseases, and cancer. Somewhat surprisingly, variables indicating trochanteric fracture and the status of long-term care patient had a protective effect in the maintainability models.
The volume of the rehabilitation unit was linearly associated with four-month mortality, and larger units were more effective (Figure 3). The trend of the spline model had a similar shape to that of the linear model but, being more complex model, its DIC (1102.4) was bigger than the one from the linear model (1097.1). A clear association was also found between the volume of the rehabilitation unit and four-month maintainability (Figure 4). The linear model and the spine model had almost the same DIC (1325.7 vs. 1325.9), but the spline model indicated that the association could be a cut-off type rather than linear so that the units treating about 25 or more hip fracture patients per year would have better results.
In this study, the volume-effectiveness relationship was examined from the methodological point of view. Recent suggestions for methodological improvements in volume-effectiveness studies could be summarized as a need for: 1) hierarchical modeling that allows risk adjustment at patient level and examination of volume effect at provider level, so that clustering and different types of volume relationships (curvelinear, linear, stepwise, cut-off) can be taken into account; and 2) an effectiveness measure that is not as rare an event as short-term mortality and that also reflects the process of care [11–13]. In this study, a methodological approach that aimed to fulfill both of these needs was developed in tandem with examining the volume-effectiveness relationship in the case of hip fracture treatment using Finnish register data.
Several studies have previously examined the volume-effectiveness relationship in the case of hip fracture treatment, but the results have been mixed [42–60]. In the current study, no volume effect was found between the hospital volume and effectiveness in terms of mortality, and there was only a weak tendency for positive association in terms of maintainability. These results are in line with the previous Finnish hip fracture study, which did not find any volume effect on mortality or acute complications . As a conclusion of the international studies, in most cases there has only been a weak trend toward greater effectiveness with higher volumes of treated hip fracture patients, and it is likely that the feasible improvements in effectiveness related to the surgeon or hospital volume are negligible compared with the unavoidable major adverse outcomes related to the hip fracture condition itself [43–60].
More interestingly, by focusing on the volume of the rehabilitation unit, there was a clear positive volume effect with both effectiveness indicators used in this study. This was a novel finding, but not a surprising one, as volume-effectiveness associations have been found in nursing home care , and it is well known that adequate rehabilitation of hip fracture patients improves effectiveness significantly [62, 63]. The exact mechanisms behind the detected relationship cannot be explained in this study, but it is likely that effectiveness is simply worse if there is no routine for hip fracture treatment. The structure-related resources and organizational learning probably also have a major, but indirect, role in the sense that the whole process of care tends to be better for providers that have greater availability of support services, possibilities for specialization, and enough resources for continuous improvements in care practices.
In regard to data sources, there are not many options for administrative registers while studying the volume-effectiveness relationship. The selection of hip fractures as the health problem of interest had certain advantages in a study using administrative data: it is a relatively common disease (enough data and relevant from the policy point of view); it is quite easy to diagnose (can be accurately identified from the registers); virtually all hip fracture patients are treated in hospital (all patients can be found from the registers); and it was possible to observe detailed treatment pathways of these, typically, elderly patients using the Finnish register data . The validity of the data was also known to be very good .
Two effectiveness indicators were used in this study: mortality and maintainability. Mortality is a well-established and commonly used effectiveness indicator that objectively captures the most serious adverse outcome. In this study, four-month mortality was used as a yardstick for the alternative maintainability indicator.
Maintainability was defined as a backward step in the levels of care, i.e., in terms of events that were robustly and completely identifiable from the register data. By capturing deaths, readmissions, and referrals to higher-level providers, the event is far more frequent than short-term mortality. It also captures more from the care process than only the death events. More complex events are likely to be harder to predict using the available background factors in the adjustment, so it was expected that the predictive power of the maintainability models was lower than of the mortality models measured using the c-statistics (Table 1). The c-statistics of the maintainability models remained at the level that is known to be rather typical for hospitalization responses with corresponding background factors .
Maintainability seems to reflect the need for care slightly better than mortality in the sense that the effects of age and sex were weaker, and many non-fatal diseases had at least a tendency to a stronger effect than in the mortality models. The protective effect of the variable indicating preceding long-term care in relation to short-term care is probably due to two overlapping reasons: many long-term care patients live in a nursing home and all their problems do not necessarily result in the need for upper-level care, and there are simply fewer upper levels of care for long-term care patients than for the patients coping at home. The protective effect of trochanteric fractures in relation to fractures of the neck of the femur may be related to differences in treatment practices of intra- and extracapsular hip fractures .
The face validity of the maintainability indicator seemed to be acceptable in this study. The interpretations of volume-effectiveness associations turned out to be quite similar to mortality, although maintainability added more details to the associations. The main drawback of the maintainability measure was that it was not specific to the health problem of interest: All backward steps in the levels of care were considered adverse outcomes regardless of the actual reasons. It also seems that the interpretations can be strengthened by restricting the analyses to subpopulations that are homogeneous in terms of possible transitions between levels of care, such as elderly hip fracture patients living at home at the time of fracture. In any case, the maintainability measure seems to reflect quite adequately whether everything has gone smoothly during the treatment process of elderly patients at the population level, as long as the potential restrictions are kept in mind.
In this study, an extended methodological approach that allows risk adjustment and hierarchical modeling of volume trends was developed. The aim was to diminish the recognized biases attributable to the use of more traditional methods. As such, the improved methodology presented in this study should be useful for further examinations of the volume-effectiveness relationship.
It must be noted, however, that the presented models were not perfect, and the approach was intended to study associations, not causality. Due to the limitations of the data, an additional level for surgeons was omitted from the models. The surgeon level would have been particularly interesting when studying hospital volumes, as patients are obviously clustered within surgeons and surgeons within hospitals (although surgeons may operate in a number of different institutions depending on the local health care configuration). In addition, another level could be incorporated to capture the variation attributable to the operative team rather than just the surgeon. On the other hand, the utility of additional levels for studying the volumes of rehabilitation units seems not to be as obvious. It is also likely that strong volume associations can be detected with simpler models, and the more complex ones may then be used to confirm and possibly explain the existing relationships. Other possible methodological development lines for further studies include the implementation of risk adjustment and volume association models as one model, relaxation of the Poisson assumption, incorporation of a more detailed variance structure, and models for responses other than binary ones.
The improved methodology presented in this study should be useful for examinations of the volume-effectiveness relationship in fairly general cases. In the current hip fracture case study, no clear relationship was found between hospital volume and effectiveness. However, for the first time ever, an association was detected between the volume of the rehabilitation unit and effectiveness. There are no indications that patients with hip fractures should only be treated in high-volume hospitals, but it may be beneficial to centralize the rehabilitation of hip fracture patients to specialized units.
The author received support from the Yrjö Jahnsson Foundation (grant number 5978). The funding agreement ensured the author's independence in designing the study, interpreting the data, writing, and publishing the report.
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