Model type (name) & equation | Variables and parameters | Reference | |
---|---|---|---|
Pharmacokinetic model (two compartment model) | |||
| for D = 5 mg: A = 3.502 ng/mL B = 1.209 ng/mL α = 0.445 h-1 β = 0.014 h ka = 1.319 h-1 lag time = 0.96 h | for D = 10 mg: A = 4.536 ng/mL B = 1.234 ng/mL α = 0.542 h-1 β = 0.015 h-1 ka = 1.696 h-1 lag time = 0.68 h | [32] |
Pharmacodynamic model (Emax model) | Emax = 100.8% EC50 = 15.6 ng/mL | [34] | |
|